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ANTI-SCLEROSTIN ANTIBODY, ANTIGEN BINDING FRAGMENT AND MEDICAL USE THEREOF

  • US 20180099046A1
  • Filed: 02/16/2016
  • Published: 04/12/2018
  • Est. Priority Date: 03/13/2015
  • Status: Active Grant
First Claim
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1. An antibody or antigen-binding fragment thereof that specifically binds to human sclerostin, comprising:

  • a heavy chain variable region HCDR sequence comprising amino acid sequences of SEQ ID NO;

    7, SEQ ID NO;

    8 or SEQ ID NO;

    9, or a mutant sequence thereof, or an amino acid sequence having at least 95% sequence identity thereto; and

    a light chain variable region LCDR sequence comprising amino acid sequences of SEQ ID NO;

    10, SEQ ID NO;

    11 or SEQ ID NO;

    12, or a mutant sequence thereof, or an amino acid sequence having at least 95% sequence identity thereto.

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