INFUSION SYSTEMS AND METHODS FOR AUTOMATED EXERCISE MITIGATION

• US 20180099092A1
• Filed: 09/27/2017
• Published: 04/12/2018
• Est. Priority Date: 10/06/2016
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Roy, Anirban
• Granted Patent: US 10,561,788 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61B 5/7242 using integration
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2202/04 Liquids
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 2205/3327 Measuring
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/06 Heartbeat rate only
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity
• CPC Class Codes: A61M 5/142 : Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/14244 : adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1452 : pressurised by means of pistons
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G16H 20/17 : delivered via infusion or injection
• CPC Class Codes: G16H 20/30 : relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: G16H 40/63 : for local operation

Abstract

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves a control system associated with the infusion device obtaining a first measurement indicative of a physiological condition of the user from a first sensing arrangement, obtaining one or more measurements from a second sensing arrangement indicative of a second condition of the user. The control system classifies the second condition as corresponding to one of a plurality of intensity levels based at least in part on the one or more measurements, and thereafter operates the infusion device to deliver the fluid to the user based on the first measurement of the physiological condition in a manner that is influenced by the intensity level classification.

Claims

1. A method of operating an infusion device capable of delivering fluid to a user, the fluid influencing a physiological condition of the user, the method comprising:

obtaining, by a control system associated with the infusion device, one or more measurements indicative of a second condition of the user different from the physiological condition;

classifying, by the control system, the second condition as one of a plurality of intensity levels based at least in part on the one or more measurements;

obtaining, by the control system, a first measurement indicative of the physiological condition of the user from a first sensing arrangement; and

operating, by the control system, the infusion device to deliver the fluid to the user based on the first measurement of the physiological condition in a manner that is influenced by the one of the plurality of intensity levels.

2. The method of claim 1, further comprising adjusting a target value based on the one of the plurality of intensity levels, resulting in an adjusted target value, wherein operating the infusion device to deliver the fluid to the user in a manner that is influenced by the one of the plurality of intensity levels comprises determining a command for operating a motor of the infusion device based on a difference between the first measurement and the adjusted target value.

3. The method of claim 2, wherein adjusting the target value comprises increasing the target value in response to classifying the second condition as aerobic exercise.

4. The method of claim 2, wherein adjusting the target value comprises decreasing the target value in response to classifying the second condition as anaerobic exercise.

5. The method of claim 1, further comprising adjusting a time constant associated with closed-loop control of the physiological condition, resulting in an adjusted time constant, wherein operating the infusion device to deliver the fluid to the user in a manner that is influenced by the one of the plurality of intensity levels comprises determining a command for operating a motor of the infusion device based on a difference between the first measurement and a target value using the closed-loop control with the adjusted time constant.

6. The method of claim 5, wherein adjusting the time constant comprises decreasing the time constant in response to classifying the second condition as aerobic exercise.

7. The method of claim 5, further comprising determining a trend associated with the physiological condition of the user based on the first measurement and one or more preceding measurements indicative of the physiological condition from the first sensing arrangement, wherein adjusting the time constant comprises:

adjusting the time constant to decrease responsiveness of the closed-loop control when the trend is positive; and

maintaining the time constant when the trend is negative.

8. The method of claim 5, wherein adjusting the time constant comprises increasing the time constant in response to classifying the second condition as anaerobic exercise.

9. The method of claim 1, further comprising decreasing a delivery limit in response to classifying the second condition as aerobic exercise, wherein operating the infusion device to deliver the fluid to the user comprises:

determining a command for operating a motor of the infusion device based on a difference between the first measurement and a target value for the physiological condition; and

limiting the command in accordance with the decreased delivery limit.

10. The method of claim 1, further comprising increasing a delivery limit in response to classifying the second condition as anaerobic exercise, wherein operating the infusion device to deliver the fluid to the user comprises determining a command for operating a motor of the infusion device based on a difference between the first measurement and a target value for the physiological condition in accordance with the increased delivery limit.

11. A method of operating an infusion device, the method comprising:

obtaining, by a control system associated with the infusion device, a current glucose measurement from a glucose sensing arrangement;

obtaining, by the control system, one or more measurements from an auxiliary sensing arrangement different from the glucose sensing arrangement;

detecting, by the control system, an exercise intensity level of a plurality of exercise intensity levels based at least in part on the one or more measurements; and

operating, by the control system, an actuation arrangement of the infusion device to deliver insulin to regulate a glucose level based on the current glucose measurement in a manner that is influenced by the exercise intensity level.

12. The method of claim 11, wherein:

determining the exercise intensity level comprises detecting aerobic exercise based at least in part on the one or more measurements; and

operating the infusion device comprises decreasing a rate or amount of insulin delivery in response to detecting aerobic exercise.

13. The method of claim 12, wherein decreasing the rate or amount of insulin delivery comprises increasing a target glucose value associated with closed-loop control of the actuation arrangement of the infusion device to regulate the current glucose measurement to the increased target glucose value.

14. The method of claim 12, wherein decreasing the rate or amount of insulin delivery comprises decreasing a derivative time constant associated with proportional-integral-derivative (PID) control of the actuation arrangement of the infusion device to regulate the current glucose measurement to a target glucose value.

15. The method of claim 11, wherein:

determining the exercise intensity level comprises detecting anaerobic exercise based at least in part on the one or more measurements; and

operating the infusion device comprises increasing a rate or amount of insulin delivery in response to detecting anaerobic exercise.

16. The method of claim 15, wherein increasing the rate or amount of insulin delivery comprises decreasing a target glucose value associated with closed-loop control of the actuation arrangement of the infusion device to regulate the current glucose measurement to the decreased target glucose value.

17. The method of claim 15, wherein increasing the rate or amount of insulin delivery comprises increasing a delivery limit associated with closed-loop control of the actuation arrangement of the infusion device to regulate the current glucose measurement to a target glucose value.

18. An infusion system comprising:

an actuation arrangement operable to deliver insulin to a user;

a glucose sensing arrangement to obtain a measured glucose value for the user;

a second sensing arrangement to obtain measurement data indicative of exercise by the user; and

a control system coupled to the actuation arrangement, the glucose sensing arrangement, and the second sensing arrangement to;

classify the exercise by the user as a first level of a plurality of levels of exercise intensity based on the measurement data;

adjust control information for operating the actuation arrangement based on the first level of exercise intensity, resulting in adjusted control information; and

operate the actuation arrangement to deliver the insulin to the user based at least in part on the adjusted control information and the measured glucose value.

19. The infusion system of claim 18, wherein the second sensing arrangement comprises a lactate sensing arrangement or a ketone sensing arrangement.

20. The infusion system of claim 18, wherein:

the adjusted control information comprises an increased target glucose value; and

the control system operates the actuation arrangement to deliver the insulin to the user based at least in part on a difference between the measured glucose value and the increased target glucose value.