APPLICATION OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY IN SENSOR SYSTEMS, DEVICES, AND RELATED METHODS
First Claim
1. A method for real-time detection of a signal dip for a working electrode of a glucose sensor, the method comprising:
- periodically performing an electrochemical impedance spectroscopy (EIS) procedure to obtain values of real impedance for said electrode;
monitoring, by a microprocessor, said values of real impedance over time;
based on said monitoring of said values of real impedance, determining, by said microprocessor, whether a dip exists in the signal generated by said working electrode; and
based on the determination that a dip exists in said signal, determining, by said microprocessor, that said working electrode is unreliable for measuring glucose.
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Abstract
A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.
3 Citations
10 Claims
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1. A method for real-time detection of a signal dip for a working electrode of a glucose sensor, the method comprising:
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periodically performing an electrochemical impedance spectroscopy (EIS) procedure to obtain values of real impedance for said electrode; monitoring, by a microprocessor, said values of real impedance over time; based on said monitoring of said values of real impedance, determining, by said microprocessor, whether a dip exists in the signal generated by said working electrode; and based on the determination that a dip exists in said signal, determining, by said microprocessor, that said working electrode is unreliable for measuring glucose. - View Dependent Claims (2, 3, 4, 5)
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6. A method for real-time detection of a signal dip for a plurality of working electrodes of a glucose sensor, the method comprising:
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periodically performing an electrochemical impedance spectroscopy (EIS) procedure for each of said plurality of working electrodes to obtain respective values of real impedance for each said electrode; monitoring, by a microprocessor, said respective values of real impedance over time; based on said monitoring of said respective values of real impedance, determining, by said microprocessor, whether at least one of said plurality of working electrodes is not experiencing a signal dip; and based on said determination, identifying, by said microprocessor, said at least one of said plurality of working electrodes that is not experiencing a signal dip for use to measure glucose. - View Dependent Claims (7, 8, 9, 10)
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Specification