DEVICE AND METHOD FOR GENERATING CALIBRATION FACTORS FOR USE IN DETERMINING BIOLOGICAL INDICATOR LEVELS IN TISSUE

• US 20180132767A1
• Filed: 05/26/2016
• Published: 05/17/2018
• Est. Priority Date: 05/26/2015
• Status: Active Grant

• Current Assignee: Happy Health, Inc.
• Original Assignee: BSX Athletics
• Inventors: RAJAN, Nithin O., FRECKLETON, Dustin M., XAVIER DA SILVEIRA, Paulo E., OLSON, Byron
• Granted Patent: US 10,420,491 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/4875 Hydration status, fluid retention of the body
• CPC Class Codes: A61B 5/6828 Leg

Abstract

Optical-electronic device configured to generate a calibration factor for use in determining optical density. The device includes at least one emitter configured to emit light, a detector configured to receive light and transmit data representative of the received light and a processor coupled to the at least one emitter and the detector. The device further includes a non-transitory storage medium coupled to the processor and configured to store instruction to cause the device to perform the calibration method. Additionally, a calibration container includes a main body, upper lid, and a lower lid. The main body is configured to receive the device and an object having known optical properties.

Claims

1. A device configured to generate at least one calibration factor for use in determining optical density, the device comprising:

at least one emitter having at least one light source, the emitter configured to emit light;

a detector configured to receive light and transmit data representative of the received light;

a processor coupled to the at least one emitter and the detector;

a non-transitory storage medium coupled to the processor and configured to store instructions to cause the device to;

emit light from the at least one light source of the at least one emitter at a predetermined current towards an object that has a known optical density;

detect, at the detector, a portion of the emitted light corresponding to the predetermined current;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.

2. The device as recited in claim 1, further comprising instructions to cause, repeatedly for each light source and each of a plurality of predetermined currents, the device to:

emit light from one of the at least one light source of the at least one emitter at one of the plurality of predetermined currents towards the object;

detect, at the detector, a portion of the emitted light corresponding to the predetermined current;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.

3. The device as recited in claim 1, wherein the at least one emitter comprises a plurality of emitters and each of the plurality of emitters having a plurality of light sources, and further comprising instructions to cause the device to:

emit light, towards the object, from one of the plurality of light sources of one of the emitters at one of a plurality of predetermined currents;

detect, at the detector, a portion of the emitted light corresponding to the one of a the plurality of predetermined currents;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.

4. The device as recited in claim 1, further comprising at least two emitters each comprising at least one light source, and repeating the following for each light source:

emit light, towards the object, from one light source of one of the emitters at a predetermined current;

detect, at the detector, a portion of the emitted light corresponding to the predetermined current;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.

5. The device as recited in claim 4, wherein the predetermined current comprises a plurality of currents and each of the steps are performed for each of the plurality of currents.

6. The device as recited in claim 5, wherein the at least two emitters are spaced at different distances from the detector.

7. The device in claim 6, further comprising instructions stored on the non-transitory storage medium to cause the device to:

confirm that at least one calibration factor is stored for each light source at the plurality of currents.

8. The device as recited in claim 7, wherein the plurality of predetermined currents are based on a corresponding plurality of predetermined currents and the calculation of the corresponding calibration factor is derived using the formula:

C_ijm=10^ODjm/D_ijm, where i is an index tracking a predetermined current value, j is an index tracking a light source, m is an index tracking a spacing between the light source and detector, OD is the optical density, and D is measured light data.

9. The device as recited in claim 7, wherein the non-transitory storage medium further comprises instructions, upon receiving a measurement command, to:

emitting, iteratively, light from one of a plurality of light sources at one of a plurality of predetermined currents towards the object;

detecting, at a detector, a portion of the emitted light corresponding to a respective one of the light sources and predetermined currents;

determining an optical density of the object based on the calibration factors.

10. The device as recited in claim 1, wherein the corresponding calibration factor is transmitted via a network interface component to a server.

11. The device as recited in claim 1, wherein the corresponding calibration factor is transmitted via a network interface component to an external electronic device.

12. The device as recited in claim 1, wherein the object is made of a material that is designed to mimic a biological tissue.

13. The device as recited in claim 1, wherein the at least one emitter comprises at least two emitters that are spaced apart from each other and from the detector.

14. The device as recited in claim 13, wherein one of the emitters is further away from the detector than the other.

15. The device as recited in claim 14, wherein each of the emitters are arranged along a ray extending from the detector.

16. The device as recited in claim 14, wherein each of the emitters are located on a same side of the detector.

17. The device as recited in claim 13, wherein each of the two emitters comprise a plurality of light sources.

18. The device as recited in claim 17, wherein each of the two emitters comprise four light sources.

19. The device as recited in claim 17, wherein each of the plurality of light sources within a given one of the at least two emitters has a different peak wavelength of emission.

20. A method for calculating at least one calibration factor for an electronic device configured to generate output data regarding a biological indicator, the method comprising:

emitting light from each one of a plurality of light sources of at least one emitter at a first one of a plurality of predetermined currents;

detecting, at a detector, a portion of the emitted light corresponding to the first predetermined current;

calculating, at a processor, a corresponding calibration factor based on the detected portion of emitted light;

storing the corresponding calibration factor in a non-transitory storage medium.

21. The method as recited in claim 20, further comprising:

repeatedly, for the remaining ones of the plurality of predetermined currents;

emitting light from each one of the plurality of light sources of the at least one emitter;

detecting, at a detector, a portion of the emitted light;

calculating, at the processor, a corresponding calibration factor based on the detected portion of emitted light;

storing the corresponding calibration factor in the non-transitory storage medium.

22. The method as recited in claim 21, wherein the predetermined current comprises a plurality of currents and each of the steps are performed for each of the plurality of currents.

23. The method as recited in claim 22, wherein the at least two emitters are spaced at different distances from the detector.

24. The method as recited in claim 23, further comprising confirming that a calibration factor is stored for each light source at the plurality of predetermined currents.

25. The method as recited in claim 24, wherein the plurality of predetermined currents are based on a corresponding plurality of predetermined currents and the calculation of the corresponding calibration factor is derived using the formula:

C_ijm=10^ODjm/D_ijm, where i is an index tracking a predetermined current value, j is an index tracking a light source, m is an index tracking a spacing between the light source and detector, OD is the optical density, and D is measured light data.

26. The method as recited in claim 25, further comprising:

emitting, iteratively, light from one of a plurality of light sources at one of a plurality of predetermined currents towards an object that has a known optical density;

detecting, at a detector, a portion of the emitted light corresponding to a respective one of the light sources and predetermined currents;

determining an optical density of the object based on the calibration factors.

27. The method as recited in claim 20, further comprising transmitting the corresponding calibration factor via a network interface component to a server.

28. The method as recited in claim 20, further comprising transmitting the corresponding calibration factor via a network interface component to a server.

29. The method as recited in claim 26, wherein the object is made of a material that is designed to mimic a biological tissue.

30. The method as recited in claim 20, wherein the at least one emitter comprises at least two emitters that are spaced apart from each other and from the detector.

31. The method as recited in claim 30, wherein one of the emitters is further away from the detector than the other.

32. The method as recited in claim 31, wherein each of the emitters are arranged along a ray extending from the detector.

33. The method as recited in claim 31, wherein each of the emitters are located on a same side of the detector.

34. The method as recited in claim 20, wherein each of the two emitters comprise a plurality of light sources.

35. The method as recited in claim 34, wherein each of the two emitters comprise four light sources.

36. The method as recited in claim 34, wherein each of the plurality of light sources within a given one of the least two emitters has a different peak wavelength of emission.

37. A system including an electronic device and a hardware server, the system configured to generate at least one calibration factor for use in determining optical density and comprising:

at least one emitter having at least one light source, the emitter configured to emit light;

a detector configured to receive light and transmit data representative of the received light;

a processor coupled to the at least one emitter and the detector;

a non-transitory storage medium coupled to the processor and configured to store instructions to cause the device to;

emit light from the at least one light source of the at least one emitter at a predetermined current towards an object that has a known optical density;

detect, at the detector, a portion of the emitted light corresponding to the predetermined current;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.

38. The system as recited in claim 37, wherein the at least one emitter, the detector, the processor, and the non-transitory storage medium are located within the electronic device.

39. The system as recited in claim 37, wherein the at least one emitter, the detector, and the processor are located within the electronic device and the non-transitory storage medium is located within the server.

40. A method for calculating a calibration factor for an electronic device configured to generate output data regarding an optical density, the method comprising:

placing, iteratively, the electronic device on one of a plurality of objects, each having a known optical density;

emitting, iteratively, light from one of a plurality of light sources at one of a plurality of predetermined currents;

detecting, at a detector, a portion of the emitted light corresponding to a respective one of the plurality of objects, light sources, and predetermined currents;

calculating, at a processor, a corresponding calibration factor based on the detected portion of emitted light;

storing the corresponding calibration factor in a non-transitory storage medium; and

determining that the non-transitory medium has a corresponding calibration factor for each combination of the plurality of objects, light sources, and predetermined currents, wherein the calibration factors are stored in a plurality of matrices, each of the plurality of matrices corresponding to one of the plurality of objects.

41. The method as recited in claim 40, further comprising generating a matrix of best fit calibration factors based on a linear fit of the plurality of matrices.

42. The method as recited in claim 41, further comprising:

placing the electronic device on an object;

emitting, iteratively, light from one of a plurality of light sources at one of a plurality of predetermined currents;

detecting, at a detector, a portion of the emitted light corresponding to a respective one of the plurality of objects, light sources, and predetermined currents;

determining an optical density of the object based on the matrix of best fit calibration factors.

43. A device configured to generate at least one calibration factor for use in determining optical density, the device comprising:

a plurality of light sources each configured to emit light;

a detector configured to receive light and transmit data representative of the received light;

a processor coupled to the plurality of light sources and the detector;

a non-transitory storage medium coupled to the processor and configured to store instructions to cause the device to;

iteratively emit light from one of the plurality of light sources at one of a plurality of predetermined current towards one of a plurality of objects, each of the plurality of objects having a known optical density;

detect, at the detector, a portion of the emitted light;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium; and

determine that the non-transitory medium has a corresponding calibration factor for each combination of the plurality of objects, light sources, and predetermined currents.

44. A device configured to generate at least one calibration factor for use in determining optical density, the device comprising:

at least one emitter having at least one light source, the emitter configured to emit light;

a detector configured to receive light and transmit data representative of the received light;

a processor coupled to the at least one emitter and the detector;

a non-transitory storage medium coupled to the processor and configured to store instructions to cause the device to;

emit light from the at least one light source of the at least one emitter at a predetermined light intensity towards an object that has a known optical density;

detect, at the detector, a portion of the emitted light corresponding to the predetermined light intensity;

calculate, at the processor, a corresponding calibration factor based on the detected portion of emitted light through the object;

store the corresponding calibration factor in the non-transitory storage medium.

45. A calibration container comprising:

a main body forming a through opening configured to receive a test sample on one side and an electronic device on another side, the electronic device is configured to emit light from a plurality of emitters and receive light at a detector;

an upper lid coupled to the main body and configured to securely enclose the one side;

an object having known optical properties;

a lower lid coupled to the main body and configured to securely enclose the another side.

46. The calibration container as recited in claim 45, further comprising a support plate configured to hold the electronic device in close proximity to the object.

47. The calibration container as recited in claim 46, wherein the support plate forms at least three through holes corresponding to locations of the plurality of emitters and the detector.

48. The calibration container as recited in claim 46, wherein the support plate is coupled to the main body via a plurality of threaded connections.

49. The calibration container as recited in claim 46, further comprising lower elastic material that is coupled to the lower lid and configured to press the object against the support plate.

50. The calibration container as recited in claim 45, wherein the lower lid is coupled to the main body via a plurality of threaded connections, thereby holding the object within the main body.

51. The calibration container as recited in claim 45, wherein the main body forms a first and second support ledge configured to support the electronic device on a first side and a second side.

52. The calibration container as recited in claim 51, further comprising an upper elastic material coupled to the upper lid and configured to hold the electronic device in place against the first support ledge and the second support ledge.

53. The calibration container as recited in claim 45, further comprising a hinge configured to couple the upper lid to the main body.

54. The calibration container as recited in claim 53, further comprising a latch configured to releasably secure the upper lid to the main body.

56. The calibration container as recited in claim 45, wherein the main body has a portion configured to receive the object.

57. The calibration container as recited in claim 45, wherein the main body is made of at least one of anodized Aluminum or Black DELRIN®

.

58. The calibration container as recited in claim 45, wherein the main body is configured to block and absorb light.