Methods for Accelerated Return of Skin Integrity and for the Treatment of Impetigo
11 Assignments
0 Petitions
Accused Products
Abstract
Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelorating the return of skin integrity and or in treating or alleviating a disorder including impetigo, acne, rosacea, a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease, wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin, or mucosa or an eye.
22 Citations
48 Claims
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1-20. -20. (canceled)
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21. A method of treating or alleviating acne, comprising topically administering at least once daily an effective amount of a minocycline antibiotic foam to a target area on a patient in need thereof, wherein the target area comprises an area of skin or mucosa, and wherein the minocycline antibiotic foam is produced from a foamable composition upon addition of a liquefied or compressed gas propellant, the foamable composition comprising:
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(a) 60% to 90% by weight of one or more hydrophobic oils selected from the group consisting of a mineral oil, a soybean oil, a coconut oil, a petrolatum, cyclomethicone, and a mixture of two or more thereof; (b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, and a mixture thereof; (c) at least one solid fatty alcohol having a carbon chain length of 14 to 22 carbons; (d) at least one solid fatty acid having a carbon chain length of 12 to 28 carbons; and (e) a minocycline at about 0.2% to 10% by weight of the foam; wherein the foamable composition does not comprise a surfactant. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A method of restoring skin integrity or accelerating restoration of an area of broken skin or mucosa due to acne, comprising topically administering at least once daily an effective amount of a minocycline antibiotic foam to the area of broken skin or mucosa, wherein the minocycline antibiotic foam is produced from a foamable composition upon addition of a liquefied or compressed gas propellant, the foamable composition comprising:
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(a) 60% to 90% by weight of one or more hydrophobic oils selected from the group consisting of a mineral oil, a soybean oil, a coconut oil, a petrolatum, cyclomethicone, and a mixture of two or more thereof; (b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, and a mixture thereof; (c) at least one solid fatty alcohol having a carbon chain length of 14 to 22 carbons; (d) at least one solid fatty acid having a carbon chain length of 12 to 28 carbons; and (e) a minocycline at about 0.2% to 10% by weight of the foam; wherein the foamable composition does not comprise a surfactant. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42)
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43. A method for healing of an infected acne lesion without scaring, comprising topically administering at least once daily an effective amount of a minocycline antibiotic foam to an infected acne lesion, wherein the minocycline antibiotic foam is produced from a foamable composition upon addition of a liquefied or compressed gas propellant, the foamable composition comprising:
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(a) 60% to 90% by weight of one or more hydrophobic oils selected from the group consisting of a mineral oil, a soybean oil, a coconut oil, a petrolatum, cyclomethicone, and a mixture of two or more thereof; (b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, and a mixture thereof; (c) at least one solid fatty alcohol having a carbon chain length of 14 to 22 carbons; (d) at least one solid fatty acid having a carbon chain length of 12 to 28 carbons; and (e) a minocycline at about 0.2% to 10% by weight of the foam; wherein the foamable composition does not comprise a surfactant. - View Dependent Claims (44, 45, 46, 47, 48)
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Specification