METHODS AND DEVICES FOR DETECTING INTENSITY OF LIGHT WITH TRANSLUCENT DETECTOR

• US 20180199871A1
• Filed: 12/21/2017
• Published: 07/19/2018
• Est. Priority Date: 12/22/2016
• Status: Active Grant

• Current Assignee: Willow Laboratories Incorporated
• Original Assignee: Cercacor Laboratories
• Inventors: Pauley, Kevin, Dalvi, Cristiano, Vo, Hung, Chen, Jesse, Lesmana, Ferdyan, Poeze, Jeroen, Merritt, Sean
• Granted Patent: US 10,750,984 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14535 for measuring haematocrit
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/4875 Hydration status, fluid retention of the body
• CPC Class Codes: G01J 1/1626 Arrangements with two photodetectors, the signals of which are compared
• CPC Class Codes: G01J 2001/1636 one detector directly monitoring the source, e.g. also impulse time controlling
• CPC Class Codes: G01J 2001/1652 one detector being transparent before the other one
• CPC Class Codes: G01N 2021/3181 using LEDs
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence
• CPC Class Codes: G01N 21/4738 Diffuse reflection precedence is given to G01N21/55 - G01N21/57 if specular component is taken into consideration, e.g. also for testing fluids, fibrous materials
• CPC Class Codes: G01N 21/49 within a body or fluid
• CPC Class Codes: G01N 21/59 Transmissivity G01N21/25 takes precedence

Abstract

An optical measurement device includes a light source, a first detector, and a second detector. The light source emits light to a measurement site of a patient and one or more detectors detect the light from the light source. At least a portion of a detector is translucent and the light passes through the translucent portion prior to reaching the measurement site. A detector receives the light after attenuation and/or reflection or refraction by the measurement site. A processor determines a light intensity of the light source, a light intensity through a tissue site, or a light intensity of reflected or refracted light based on light detected by the one or more detectors. The processor can estimate a concentration of an analyte at the measurement site or an absorption or reflection at the measurement site.

Claims

1. An optical measurement device comprising:

a light source configured to emit light to a measurement site;

a first detector configured to receive incident light from the light source, wherein at least a portion of the first detector is translucent and the incident light passes through the at least one translucent portion prior to reaching the measurement site; and

a second detector configured to receive the light after attenuation by the measurement site.

2. The device of claim 1, wherein the optical measurement device comprises a pulse oximetry device and the measurement site comprises a tissue site of a patient.

3. The device of claim 1, wherein the measurement site comprises non-biological material.

4. The device of claim 1, wherein the measurement site comprises biological material.

5. The device of claim 1, wherein the first detector is proximal to the light source with respect to the measurement site, the first detector is proximal to the light source with respect to the second detector, the second detector is distal to the first detector with respect to the measurement site.

6. The device of claim 1, wherein the first detector is configured detect the incident light in real-time.

7. The device of claim 1, further comprising:

a housing configured to house the light source; and

flexible connections or flexible cabling configured to electrically connect the first detector to the housing.

8. The device of claim 1, wherein the first detector comprises an antireflective (AR) coating layer, a photodiode layer, and a wafer layer.

9. A method of estimating a concentration of an analyte of interest at a measurement site, the method comprising:

receiving incident light from a light source at a first detector, wherein at least one portion of the first detector is translucent and the incident light is received by and passes through the at least one translucent portion before reaching a measurement site;

determining an intensity of the incident light based at least in part on the incident light received by the first detector;

receiving attenuated light at a second detector, wherein the attenuated light is the light which emerges from the measurement site;

determining an intensity of the attenuated light based at least in part on the attenuated light received by the second detector; and

estimating a concentration of an analyte at the measurement site based at least in part on the intensity of the incident light and the intensity of the attenuated light.

10. The method of claim 9, wherein the measurement site is a tissue site of a patent, and wherein the method further comprises estimating one or more physiological parameters of the patient based at least in part on the estimated concentration of the analyte at the tissue site.

11. The method of claim 9, wherein the concentration of the analyte corresponds to blood glucose concentration.

12. The method of claim 9, wherein the measurement site comprises non-biological material.

13. An optical measurement device comprising:

a light source configured to emit light to a measurement site; and

a detector comprising a translucent portion, wherein the detector is configured to detect light as it passes through the translucent portion.

14. The device of claim 13, wherein the detector is configured to detect incident light of the light source before light from the light source is attenuated by the measurement.

15. The device of claim 13, wherein the detector is configured to detect light reflected or refracted by the measurement site.

16. The device of claim 13, wherein the detector is a first detector, wherein the first detector is configured to detect incident light from the light source before light from the light source is attenuated by the measurement site, wherein the device further comprises a second detector configured to receive the light after attenuation by the measurement site.

17. The device of claim 13, wherein the first detector is proximal to the light source with respect to the tissue site.

18. The device of claim 13, wherein the optical measurement device comprises a pulse oximetry device and the measurement site comprises a tissue site of a patient.

19. The device of claim 13, wherein the measurement site comprises non-biological material.

20. The device of claim 13, wherein the measurement site comprises biological material.