MICROCIRCULATION SHOCK MONITOR ENABLING RAPID AND REPEATED POSITIONING, MONITORING SYSTEM AND MONITORING METHOD

• US 20180303352A1
• Filed: 06/25/2018
• Published: 10/25/2018
• Est. Priority Date: 01/12/2016
• Status: Active Grant

• Current Assignee: Xinghuai Feng
• Original Assignee: Xinghuai Feng
• Inventors: FENG, Xinghuai, ZHANG, Xiaoping
• Granted Patent: US 10,898,080 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/004 adapted for image acquisition of a particular organ or body part A61B5/0082 takes precedence; arrangements for optical scanning A61B5/0062
• CPC Class Codes: A61B 5/0088 for oral or dental tissue
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/4552 Evaluating soft tissue within the mouth, e.g. gums or tongue
• CPC Class Codes: G02B 21/0008 Microscopes having a simple construction, e.g. portable microscopes
• CPC Class Codes: G02B 21/0012 Surgical microscopes counterbalanced structures for surgical microscopes G02B7/001
• CPC Class Codes: G02B 21/361 Optical details, e.g. image relay to the camera or image sensor G02B21/364 takes precedence; illumination details G02B21/06 and subgroups
• CPC Class Codes: G02B 21/365 Control or image processing arrangements for digital or video microscopes G02B21/361, G02B21/362 take precedence
• CPC Class Codes: G06T 2207/30104 Vascular flow; Blood flow; Perfusion
• CPC Class Codes: G06T 7/0014 using an image reference approach

Abstract

The present invention discloses a microcirculation shock monitor enabling rapid and repeated positioning, a monitoring system and a monitoring method, belonging to the technical field of microcirculation shock monitoring. By the present invention, the same blood vessel in the same monitored area can be repeatedly positioned and monitored quickly within different periods of time, and blood vessel image data can be acquired, and then, on this basis, qualitative analysis or quantitative analysis is performed to obtain related monitored data, where quantitative analysis parameters comprise a high-speed blood flow intensity ratio R, a high-speed blood flow spreading rate S, a high-speed blood flow intensity duration T and a difference D of abnormal change in high-speed blood flow intensity of a monitored object, which facilitates studies and lays an accurate data foundation for rapidly indicating early and middle stage indications of infectious shock in a next step.

Claims

1. A microcirculation shock monitor enabling rapid and repeated positioning, comprising a host body (15), wherein a front end of the host body (15) is mounted with a probe device (1), the host body (15) is internally provided with a microscope continuous zooming mechanism (4), two ends of the microscope continuous zooming mechanism (4) are respectively mounted with a front lens (4-4) and a rear lens (4-2), the rear lens (4-2) is directly connected behind to a camera (7), at least one zooming lens (4-3) capable of reciprocating along a direction of a zooming mechanism driving and guiding device (4-1) is provided between the front lens (4-4) and the rear lens (4-2).

2. The microcirculation shock monitor enabling rapid and repeated positioning according to claim 1, wherein a focusing tube (2) is mounted in a rear portion of the probe device (1) or on the front lens (4-4) of the microscope continuous zooming mechanism or on the camera (7).

3. The microcirculation shock monitor enabling rapid and repeated positioning according to claim 1, wherein a direction adjustment mechanism (5) and/or a parfocalization mechanism (8) and/or a cross calibration mechanism (6) is mounted between the microscope continuous zooming mechanism (4) and the camera (7).

4. The microcirculation shock monitor enabling rapid and repeated positioning according to claim 1, wherein the host body (15) is provided with a probe sleeve (9) at the front end, the probe device (1) is mounted on the probe sleeve (9) in a way of being movable relative to the host body (15) in an axial movement direction (16), and an adjustment and positioning device (10) is mounted between the probe sleeve (9) and the probe device (1).

5. The microcirculation shock monitor enabling rapid and repeated positioning according to claim 1, wherein a handle (13) is further provided on the host body (15) for facilitating holding and controlling a viewing angle.

6. The microcirculation shock monitor enabling rapid and repeated positioning according to claim 1, wherein a disposable sterile sheath (14) is provided on the probe device (1).

7. A microcirculation shock monitoring system, comprising:

a data acquisition module, configured to repeatedly position the same blood vessel in the same monitored area and acquire blood vessel image data;

a data preprocessing module, configured to filter and stabilize the acquired blood vessel image data;

a comparison module, configured to compare measured stabilized blood vessel image data with reference data, to judge and analyze changes in a blood flow rate in the blood vessel and/or changes in distribution density of the blood vessel; and

a storage module, configured to store the measured blood vessel image data and the reference data in a database.

8. The microcirculation shock monitoring system according to claim 7, wherein

the data preprocessing module comprises a blood flow rate measurement module, configured to generate real-time flow rate data in the blood vessel;

data stored in the storage module comprises real-time data and historical data of the blood vessel images of a monitored object, average data of highest microcirculation blood flow rates of a healthy person, difference data of changes in blood flow rates of the healthy person, and stabilized data of said data; and

in the comparison module, one or more of the following quantitative analysis parameters are includes;

i) high-speed blood flow intensity ratio, referring to a ratio of an average of highest blood flow rates in a sublingual microcirculation of a patient with infectious shock within a field of view to an average of highest rates in a sublingual microcirculation of a healthy person;

that is, the high-speed blood flow intensity ratio is R=P/N*100%,

where P is the average of highest blood flow rates in the sublingual microcirculation of the patient with infectious shock within the field of view; and

N is the average of highest blood flow rates in the sublingual microcirculation of the healthy person;

the high-speed blood flow intensity ratio is mainly used to evaluate strength of a high-speed blood flow;

ii) high-speed blood flow similarity, referring to a ratio of a total length of all blood vessels at a high blood flow rate to a total length of all capillaries in the sublingual microcirculation of a patient with infectious shock within the field of view;

the high-speed blood flow spreading rate is S=HL/TL*100%,

where HL is the total length of all blood vessels at a high-speed blood flow rate within the field of view, and

TL is the total length of all blood vessels within the same field of view; and

the high-speed blood flow spreading rate is mainly used to evaluate whether the high-speed blood flow is activated completely;

iii) high-speed blood flow intensity duration, referring to a time interval between a time when a high-speed blood flow is found in a sublingual microcirculation of a patient with infectious shock for a first time and a time when the high-speed blood flow begins to decelerate;

the high-speed blood flow intensity duration is T=T2−

T1,

where T is the high-speed blood flow intensity duration;

T1 is the time when the high-speed blood flow is found for the first time, and it also can be traced and judged according to other manifestations of the patient,

T2 is the time when the high-speed blood flow begins to decelerate; and

the high-speed blood flow intensity duration is mainly used to trace and track a possible historical occurrence time of the high-speed blood flow, to judge a possible approaching time of the infectious shock; and

iv) difference of abnormal change in high-speed blood flow intensity, referring to acceleration change of the high-speed blood flow rates of the sublingual microcirculation of a patient with infectious shock, i.e., abnormal acceleration or abnormal deceleration of the high-speed blood flow rates of the sublingual microcirculation of the patient with infectious shock within different periods of time,

the difference of abnormal change in high-speed blood flow intensity is D=D1−

D2,

where D is a difference of abnormal change in high-speed blood flow intensity of the patient with infectious shock,

D1 is a difference of changes in highest blood flow rate of the patient with infectious shock,

D2 is a difference of changes in highest blood flow rate of a healthy person,

the difference of changes in the highest blood flow rate of the patient with infectious shock is D1=P2−

P1,

Where P2 is an average of last measured highest blood flow rates of the patient with infectious shock;

P1 is an average of previously measured highest blood flow rates of the patient with infectious shock;

if D1 is greater than 0, it means that the blood flow rate is accelerated;

if D1 is less than 0, it means that the blood flow rate is decelerated;

if D1 is equal to 0, it means that the blood flow rate is stable;

D2=P4−

P3,

where D2 is a difference of changes in highest blood flow rate of the healthy person;

P4 is an average of last measured highest blood flow rates of the healthy person;

P3 is an average of previously measured highest blood flow rates of the healthy person; and

the difference of abnormal change in high-speed blood flow mainly reflects abnormal acceleration change of the high-speed blood flow.

9. The microcirculation shock monitoring system according to claim 7, wherein

the storage module comprises a blood flow rate quick-matching sample template, and the blood flow rate quick-matching sample template comprises a set of flow rate video templates on which flow rates are accurately marked, for quickly comparing and judging the flow rate in the blood vessel from real-time blood vessel image data.

10. A method for monitoring blood flow change parameters in blood vessels in microcirculation for shock monitoring, comprising:

repeatedly positioning a blood vessel in the same monitored area and acquiring blood vessel image data;

filtering and stabilizing the acquired blood vessel image data;

storing measured blood vessel image data and reference data in a database; and

comparing the measured blood vessel image data having been stabilized with the reference data, and judging and analyzing changes in flow rate in the blood vessel and/or changes in distribution density of the blood vessel.

11. The method for monitoring blood flow change parameters in blood vessels in microcirculation for shock monitoring according to claim 10, wherein the step of judging and analyzing is as follows:

in comparing the blood vessel images, taking real-time blood vessel image data having been stabilized as the measured data, taking the data of the blood vessel image of the same blood vessel in the same previously monitored area having undergone stabilization as the reference data, and judging the change in flow rate in the blood vessel and/or the density change upon an operator'"'"'s observation with naked eyes.

12. The method for monitoring blood flow change parameters in blood vessels in microcirculation for shock monitoring according to claim 10, wherein the step of judging and analyzing is as follows:

measuring the flow rate of the blood flow after the step of filtering and stabilizing the acquired blood vessel image data, for generating a real-time flow rate in the blood vessel;

data stored in the database comprises real-time data and historical data of blood vessel images of a monitored object, average data of highest microcirculation blood flow rates of a healthy person, difference data of changes in blood flow rates of the healthy person, and stabilized data of said data;

in comparing the blood vessel images, four quantitative analysis indices are involved;

i) a first quantitative analysis parameter is high-speed blood flow intensity ratio;

the high-speed blood flow intensity ratio refers to a ratio of an average of highest blood flow rates in sublingual microcirculation of a patient with infectious shock within a field of view to an average of highest blood flow rates in a sublingual microcirculation of a healthy person;

that is, the high-speed blood flow intensity ratio is R=P/N*100%,

where P is the average of highest blood flow rates in the sublingual microcirculation of the patient with infectious shock within the field of view; and

N is the average of highest blood flow rates in the sublingual microcirculation of the healthy person; and

the high-speed blood flow intensity ratio is mainly used to evaluate the high-speed blood flow intensity;

ii) a second quantitative analysis parameter is high-speed blood flow similarity;

the high-speed blood flow spreading rate refers to a ratio of a total length of all blood vessels at a high blood flow rate to a total length of all capillaries in the sublingual microcirculation of the patient with infectious shock within the field of view;

the high-speed blood flow spreading rate is S=HL/TL*100%,

where HL is the total length of all blood vessels at a high blood flow rate within the field of view, and

TL is the total length of all blood vessels within the same field of view; and

the high-speed blood flow spreading rate is mainly used to evaluate whether the high-speed blood flow is activated completely;

iii) a third quantitative analysis parameter is high-speed blood flow intensity duration;

the high-speed blood flow intensity duration refers to a time interval between a time when the high-speed blood flow is found for the first time in the sublingual microcirculation of the patient with infectious shock and a time when the high-speed blood flow begins to decelerate;

T=T2−

T1,

where T is the high-speed blood flow intensity duration;

T1 is the time when the high-speed blood flow is found for the first time, and also can be traced and judged according to other manifestations of the patient,

T2 is the time when the high-speed blood flow begins to decelerate; and

the high-speed blood flow intensity duration is mainly used to trace and track a possible historical time of occurrence of the high-speed blood flow and judge a possible approaching time of the infectious shock; and

iv) a fourth quantitative analysis index is difference of abnormal change in high-speed blood flow;

the difference of abnormal change in high-speed blood flow intensity refers to acceleration change of the high-speed blood flow rates of the sublingual microcirculation of the patient with infectious shock, i.e., abnormal acceleration or abnormal deceleration of the high-speed blood flow rates of the sublingual microcirculation of the patient with infectious shock within different periods of time;

the difference of abnormal change in high-speed blood flow intensity is D=D1−

D2,

where D is the difference of abnormal change in high-speed blood flow intensity of the patient with infectious shock,

D1 is the difference of changes in highest blood flow rate of the patient with infectious shock,

D2 is the difference of changes in highest blood flow rate of the healthy person,

the difference of changes in highest blood flow rate of the patient with infectious shock is D1=P2−

P1,

where P2 is an average of last measured highest blood flow rates of the patient with infectious shock;

P1 is an average of previously measured highest blood flow rates of the patient with infectious shock;

if D1 is greater than 0, it means that the blood flow rate is accelerated;

if D1 is less than 0, it means that the blood flow rate is decelerated;

if D1 is equal to 0, it means that the blood flow rate is stable;

D2=P4−

P3,

where D2 is a difference of changes in highest blood flow rate of the healthy person;

P4 is an average of last measured highest blood flow rates of the healthy person;

P3 is an average of previously measured highest blood flow rates of the healthy person; and

the difference of abnormal change in high-speed blood flow mainly reflects abnormal acceleration change of the high-speed blood flow.