Formulation of Solid Nano-Sized Particles in a Gel-Forming System

• US 20180339068A1
• Filed: 07/31/2018
• Published: 11/29/2018
• Est. Priority Date: 11/25/2011
• Status: Active Grant

• Current Assignee: Danmarks Pã¦Dagogiske Universitet
• Original Assignee: Danmarks Pã¦Dagogiske Universitet
• Inventors: JOLCK, Rasmus Irming, ALBRECHTSEN, Morten, BJERG, Lise Norkjaer, ANDRESEN, Thomas Lars
• Granted Patent: US 10,434,192 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/505 for diagnosis of bone
• CPC Class Codes: A61K 49/04 X-ray contrast preparations
• CPC Class Codes: A61K 49/0457 Semi-solid forms, ointments, gels, hydrogels
• CPC Class Codes: A61K 49/0485 Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The present invention relates to novel formulations comprising a plurality of nano-sized solid particles and a gel-forming system, useful, e.g. for imaging of the body of a mammal. Also described are kits comprising such formulations and imaging methods utilizing such formulations or kits.

Claims

1-38. -38. (canceled)

39. A method or recording an X-ray image of the body of a mammal, comprising the steps of

a. providing a formulation comprising a plurality of solid in-organic particles and an organic gel-forming system, wherein said solid in-organic particles have a (number) average diameter of 1-500 nm and comprise or consist of a compound detectable by X-ray imagaing;

b. administering the formulation to a predetermined location of the mammal, and

c. recordind X-ray-based messages, such as Comuted Tomography (CT)-images, of at least a part of the body which comprises the predetermined location.

40. A method of joint radiotherapy and X-ray imaging of a target tissue in a mammal, comprising the steps of

a. providing a formulation comprising a plurality of solid in-organic particles and an organic gel-forming system, wherein said solid in-organic particles have a (number) average diameter of 1-500 nm and comprise or consist of a compound detectable by X-ray imaging;

b. administering the formulation to a predetermined target tissue of the mammal,

c. recording X-ray-based images, such as Computer Tomography (CT)-images, of a least a part of the body which comprises the target tissues, thereby providing a definition of the target tissue, and

d. using the definition of the target tissue obtained in c) to direct external beam radiotherapy to the target tissue.

42. The method according to claim 40, wherein the target tissue comprises undesirably growing cells.

43. The method according the claim 40, wherein the target tissues comprises tumour cells.

44. The method according to claim 40, wherein steps c) and d) are performed simultaneously.

41. A method for directing local administration of a pharmaceutically active agent to a target tissue in a mammal, comprising the steps of

a. providing a formulation comprising a plurality of solid in-organic particles and an organic gel-forming system, wherein said solid in-organic particles have a (number) average diameter of 1-500 nm and comprise or consist of a detectable compound, optionally detectable by X-ray imaging;

b. administering the formulation to a predetermined target tissue of the mammal,

c. recording images, such as Computed Tomgoraphy (CT)-images, of at least a part of the body which comprises the target tissue, thereby providing a definition of the target tissue, and

d. using the definition of the target tissue obtained in c) to direct local administration of a pharmaceutically active agent to the target tissue.