COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE
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Abstract
Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn'"'"'s Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
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88 Claims
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1-72. -72. (canceled)
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73. A method of detecting the presence of inflammatory bowel disease in a subject, the method comprising:
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(a) obtaining a biological sample from the subject; (b) contacting the biological sample with a polypeptide having at least 90% identity to an amino acid sequence of any one of SEQ ID NO;
79, 84, 86, 80-82, 38-50, or 88-89;(c) detecting an amount of an antibody in the biological sample that binds to the polypeptide; and (d) comparing the amount of bound antibody to a predetermined cut-off value, wherein the presence of inflammatory bowel disease is detected when the amount of bound antibody is higher than the cut-off value. - View Dependent Claims (74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88)
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Specification