NOVEL SENSOR INITIALIZATION METHODS FOR FASTER BODY SENSOR RESPONSE
First Claim
1. An analyte sensor apparatus, comprising:
- a base substrate;
an analyte sensing layer disposed over the electrode, wherein the analyte sensing layer detectably alters electrical current at the electrode in a presence of an analyte;
an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates diffusion of the analyte therethrough; and
a circuit coupled to the electrode, the circuit generating and transmitting an initialization voltage to the electrode and the initialization voltage comprising a ramped voltage combined with a biphasic pulse.
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Abstract
A method of initializing a sensor with a voltage sequence including a ramped voltage combined with a biphasic voltage pulse. The initialization scheme results in faster in-vitro sensor run-in and stabilization times. In various examples, the in-vitro sensor stabilization time is reduced from 200 minutes to 40-55 minutes (a reduction by a factor of least 5 as compared to a non-initialized sensor). In addition, staircase voltage initialization is implemented adaptively so that the voltage step size and sweep rates are changed depending on the state of the sensor (characterized by ISIG magnitude). As a result, individual sensors can be initialized in a customized manner rather than by using a general hardwired and harsh initialization scheme.
2 Citations
21 Claims
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1. An analyte sensor apparatus, comprising:
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a base substrate; an analyte sensing layer disposed over the electrode, wherein the analyte sensing layer detectably alters electrical current at the electrode in a presence of an analyte; an analyte modulating layer disposed over the analyte sensing layer, wherein the analyte modulating layer modulates diffusion of the analyte therethrough; and a circuit coupled to the electrode, the circuit generating and transmitting an initialization voltage to the electrode and the initialization voltage comprising a ramped voltage combined with a biphasic pulse. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of making a sensor, comprising:
connecting a circuit to a working electrode in a sensor comprising; a base substrate; the working electrode on the base substrate, wherein the working electrode comprises metal having an electroactive surface; an analyte sensing layer disposed over the working electrode, wherein the analyte sensing layer detectably alters electrical current at the working electrode in a presence of an analyte; and wherein the circuit generates and transmits an initialization voltage to the working electrode, the initialization voltage comprising a ramped voltage combined with a biphasic pulse so as to form the metal having a stable (steady state) charge distribution. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of making a sensor comprising:
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connecting a circuit to a working electrode in a sensor comprising; a base substrate; the working electrode disposed on the base substrate, the working electrode comprising a metal having an electroactive surface; an analyte sensing layer disposed over the working electrode, wherein; the analyte sensing layer detectably alters the electrical current at the working electrode in the presence of an analyte, and the circuit generates and transmits a ramped voltage to the electroactive surface, measuring the electrical current as a function of the ramped voltage; determining, in a computer, the threshold voltage in the ramped voltage at and above which the electrical current is faradaic, so that when the circuit generates and transmits an initialization voltage sequence to the working electrode, an initial voltage in the initialization voltage sequence is at least equal to, or within 5%, of the threshold voltage, so as to form the metal having a stable (steady state) charge distribution. - View Dependent Claims (21)
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20. The method 19, wherein:
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the measuring comprises, for each of a plurality of the voltages in the ramped voltage, measuring the electrical current at a first time and a second time later than the first time, and the determining comprises; comparing the electrical current at the two different times; and selecting the threshold voltage as the lowest voltage in the voltage ramp for which the electrical current measured at the first time is higher than the electrical current measured at the second time.
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Specification