FILM-FORMING COMPOSITIONS FOR THE FILM-COATING OF SOLID FORMS

• US 20190038563A1
• Filed: 08/06/2018
• Published: 02/07/2019
• Est. Priority Date: 03/29/2013
• Status: Active Grant

• Current Assignee: Roquette Freres
• Original Assignee: Roquette Freres
• Inventors: PARISSAUX, Xavier, LE BIHAN, Gregory, CROQUET, Sebastien
• Granted Patent: US 11,033,504 B2
• Time in Patent Office: Days
• CPC Class Codes: A23L 27/34 Sugar alcohols
• CPC Class Codes: A23P 20/00 Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
• CPC Class Codes: A61K 36/31 Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
• CPC Class Codes: A61K 9/282 Organic compounds, e.g. fats
• CPC Class Codes: A61K 9/2826 Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
• CPC Class Codes: A61K 9/286 Polysaccharides, e.g. gums; Cyclodextrin
• CPC Class Codes: A61K 9/2893 Tablet coating processes mechanical aspects A61J3/06
• CPC Class Codes: C08K 5/053 Polyhydroxylic alcohols
• CPC Class Codes: C09D 103/08 Ethers

Abstract

The invention relates to a film-forming composition comprising a fluidised hydroxypropyl starch and sorbitol, and to a film-coating method using said composition. The invention further relates to film-coated solid forms comprising a fluidised hydroxypropyl starch and sorbitol in the coating.

Claims

1. A film-forming composition, in particular intended for the film-coating of solid forms, characterized in that it comprises a fluidized hydroxypropyl starch and sorbitol and in that the sorbitol is included in said film-forming composition at a content of between 5% and 80% by dry weight relative to the dry weight of fluidized hydroxypropyl starch, preferentially between 5% and 40%, more preferentially between 15% and 35%, the limit at 35% being preferentially excluded.

2. The film-forming composition as claimed in claim 1, characterized in that the fluidized hydroxypropyl starch is a corn and/or legume starch, preferentially a pea starch, more preferentially a smooth pea starch.

3. The film-forming composition as claimed in claim 1, characterized in that the fluidized hydroxypropyl starch and the sorbitol together represent between 15% and 100% by dry weight relative to the total weight of the solids of said film-forming composition, preferentially between 30% and 95%, more preferentially between 60% and 95%.

4. The film-forming composition as claimed in claim 1, characterized in that it also comprises an antiaggregating agent, preferentially stearic acid.

5. The film-forming composition as claimed in claim 1, characterized in that it also comprises an opacifying agent, preferentially titanium dioxide.

6. The film-forming composition as claimed in claim 1, characterized in that the fluidized hydroxypropyl starch is made soluble.

7. The film-forming composition as claimed in claim 1, characterized in that it is a ready-to-use product.

8. The film-forming composition as claimed in claim 1, characterized in that it is an aqueous composition.

9. The aqueous film-forming composition as claimed in claim 1, characterized in that it has a solids content of between 5% and 50% by weight, preferentially between 10% and 35%, more preferentially between 15% and 30%.

10. The aqueous film-forming composition as claimed in claim 8, characterized in that it has a Brookfield viscosity, at 25°

C., of less than or equal to 500 mPa·

s, more preferentially of between 50 and 500 mPa·

s, more preferentially between 80 and 300 mPa·

s.

11. A film-coating process, characterized in that it comprises:

a step a′

) of spraying an aqueous film-forming composition as defined in claim 8 on to a moving bed of solid forms,

a step b) of drying the solid forms thus film-coated, preferentially concomitant with step

12. A film-coating process, characterized in that it comprises:

a step a) of producing an aqueous film-forming composition comprising mixing a ready-to-use product as defined in claim 7 with water,

a step a′

) of spraying the aqueous film-forming composition obtained in step a) on to a moving bed of solid forms,

a step b) of drying the solid forms thus film-coated, preferentially concomitant with step a′

).

13. The film-coating process as claimed in claim 11, characterized in that the bed of solid forms is preheated to a temperature of between 30 and 60°

C., preferentially between 30 and 40°

C., in particular of about 35°

C.

14. A solid form comprising a core covered with at least one film-coating layer, characterized in that this film-coating layer comprises a fluidized hydroxypropyl starch and sorbitol, and in that the sorbitol is included in said film-coating layer at a content of between 5% and 80% by dry Weight relative to the dry weight of fluidized hydroxypropyl starch, preferentially of between 5% and 40%, more preferentially between 15% and 35%, the limit at 35% being preferentially excluded.

15. A film, in particular an orodispersible film, characterized in that it comprises a fluidized hydroxypropyl starch and sorbitol, and in that the sorbitol is included in said film at a content of between 5% and 80% by dry weight relative to the dry weight of fluidized hydroxypropyl starch, preferentially of between 5% and 40%, more preferentially between 15% and 35%, the limit at 35% being preferentially excluded,