RADIOACTIVE LIQUID EMBOLIC

• US 20190105425A1
• Filed: 10/09/2018
• Published: 04/11/2019
• Est. Priority Date: 10/09/2017
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Cruise, Gregory M., Wu, Xinping, Fitz, Matthew J., Wu, Yue
• Granted Patent: US 10,576,182 B2
• Time in Patent Office: Days
• CPC Class Codes: A61L 2300/428 Vitamins, e.g. tocopherol, riboflavin
• CPC Class Codes: A61L 2300/44 Radioisotopes, radionuclides
• CPC Class Codes: A61L 24/0005 Ingredients of undetermined constitution or reaction products thereof
• CPC Class Codes: A61L 24/001 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507

Abstract

Liquid embolic preparations and medical treatment methods of using those preparations are described. In some embodiments, the preparations or solutions can transition from a liquid to a solid for use in the embolization. The preparations can include biocompatible polymers with covalently bound radioactive iodine isotopes.

Claims

1. A polymeric composition comprising:

a substantially stable biocompatible polymer comprising a reaction product of;

a first monomer including a polymerizable moiety having a linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope,

and a second monomer including a polymerizable moiety and at least one hydroxyl group; and

a non-physiological solution;

wherein the substantially stable biocompatible polymer is soluble in the non-physiological solution and insoluble in a physiological solution.

2. The polymeric composition of claim 1, wherein the linkage is biodegradable.

3. The polymeric composition of claim 1, further including folic acid or a functionalized form thereof.

4. The polymeric composition of claim 1, wherein the radioactive isotope is ¹²³I, ¹²⁴I, ¹²⁵I, ¹³¹I, or a combination thereof.

5. The polymeric composition of claim 1, wherein the radioactive isotope is ¹²³I.

6. The polymeric composition of claim 1, wherein the radioactive isotope is ¹²⁴I.

7. The polymeric composition of claim 1, wherein the radioactive isotope is ¹²⁵I.

8. The polymeric composition of claim 1, wherein the radioactive isotope is ¹³¹I.

9. The polymeric composition of claim 1, wherein the first monomer is functionalized triiodophenol, 1-((2-(methacryloyloxy)ethoxy)carbonyloxy)ethyl-3,5-diacetamido-2,4,6-triiodobenzoate, 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2-yloxy)ethoxy)ethyl acrylate, or a combination thereof.

19. A method of embolization, the method including:

delivering a polymeric composition of claim 1 to a lumen in need thereof.

10. A polymeric composition comprising:

substantially stable biocompatible polymer particles, wherein the polymer particles include a reaction product of;

a first monomer including a polymerizable moiety having a linkage to a visualization agent having at least one aromatic ring, wherein the at least one aromatic ring includes at least one iodine atom, wherein at least one of the at least one iodine atom is a radioactive isotope,

and a second monomer including a polymerizable moiety.

11. The polymeric composition of claim 10, wherein the linkage is biodegradable.

12. The polymeric composition of claim 10, further including folic acid or a functionalized form thereof.

13. The polymeric composition of claim 10, wherein the radioactive isotope is ¹²³I, ¹²⁴I, ¹²⁵I, ¹³¹I, or a combination thereof.

14. The polymeric composition of claim 10, wherein the radioactive isotope is ¹²³I.

15. The polymeric composition of claim 10, wherein the radioactive isotope is ¹²⁴I.

16. The polymeric composition of claim 10, wherein the radioactive isotope is ¹²⁵I.

17. The polymeric composition of claim 10, wherein the radioactive isotope is ¹³¹I.

18. The polymeric composition of claim 10, wherein the first monomer is functionalized triiodophenol, 1-((2-(methacryloyloxy)ethoxy)carbonyloxy)ethyl-3,5-diacetamido-2,4,6-triiodobenzoate, 2-oxo-2-(1-oxo-1-(1-oxo-1-(2,4,6-triiodophenoxy)propan-2-yloxy)propan-2-yloxy)ethoxy)ethyl acrylate, or a combination thereof.

20. A method of embolization, the method including:

delivering a polymeric composition of claim 10 to a lumen in need thereof.