ELECTRICALLY ENHANCED RETRIEVAL OF MATERIAL FROM VESSEL LUMENS

• US 20190175200A1
• Filed: 12/11/2017
• Published: 06/13/2019
• Est. Priority Date: 12/11/2017
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Girdhar, Gaurav, Nguyen, Dinh, Nguyen, Hoai
• Granted Patent: US 10,709,463 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 17/22031 Gripping instruments, e.g. forceps, for removing or smashing calculi A61B17/221 takes precedence
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 18/08 by means of electrically-heated probes
• CPC Class Codes: A61B 18/10 Power sources therefor
• CPC Class Codes: A61B 2017/00017 Electrical control of surgical instruments
• CPC Class Codes: A61B 2017/00929 isolating electrical current
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/22042 Details of the tip of the guide wire
• CPC Class Codes: A61B 2017/2215 having an open distal end
• CPC Class Codes: A61B 2018/00214 Expandable means emitting energy, e.g. by elements carried thereon
• CPC Class Codes: A61B 2018/00345 Vascular system
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2002/9511 the retaining means being filaments or wires
• CPC Class Codes: A61F 2002/9528 for retrieval of stents

Abstract

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the removal device. The removal device can have a core assembly that includes a hypotube coupled to a first electrical terminal and a pushwire coupled to a second electrical terminal, the pushwire extending through the hypotube lumen. An insulating layer separates the hypotube and the pushwire, and an interventional element is coupled to a distal end of the pushwire. The interventional element can be disposed adjacent to a thrombus. An electrical signal is delivered to the interventional element to promote adhesion of the thrombus to the interventional element. The electrical signal can optionally be a periodic waveform, and the total energy delivered can be between 0.75-24,000 mJ and the peak current delivered via the electrical signal can be between 0.5-5 mA.

Claims

1. A method for thrombectomy, comprising:

disposing an interventional element adjacent to a thrombus within a blood vessel;

promoting adhesion of the thrombus to the interventional element by delivering an electrical signal to the interventional element, the electrical signal comprising a periodic waveform,

wherein the total energy delivered via the electrical signal is between 0.75-24,000 mJ, and

wherein the peak current delivered via the electrical signal is between 0.5-5 mA.

2. The method of claim 1, wherein the electrical signal is delivered for no more than 2 minutes.

3. The method of claim 1, wherein the total energy delivered via the electrical signal is between 120-5000 mJ.

4. The method of claim 1, wherein the total charge delivered via the electrical signal is between 30-1200 mC.

5. The method of claim 4, wherein the total charge delivered via the electrical signal is between 120-160 mC.

6. The method of claim 1, wherein the frequency of the electrical signal is between 1 Hz to 1 MHz.

7. The method of claim 6, wherein the frequency of the electrical signal is between 1 Hz to 1 kHz

8. The method of claim 1, wherein the duty cycle of the electrical signal is between 5-99%.

9. The method of claim 8, wherein the duty cycle of the electrical signal is between 5-20%.

10. The method of claim 1, wherein the waveform comprises a non-square waveform.

11. The method of claim 1, wherein the waveform comprises a composite waveform including the superposition of a square waveform and a non-square waveform.

12. The method of claim 11, wherein the non-square waveform comprises a triangular waveform.

13. The method of claim 1, wherein the interventional element comprises an electrically conductive self-expandable device.

14. The method of claim 1, further comprising removing the thrombus from the blood vessel.

15. The method of claim 1, further comprising retracting the interventional element, thereby displacing the thrombus.

16. The method of claim 1, wherein delivering the electrical signal to the interventional element is not substantially thrombogenic.

17. The method of claim 1, wherein the interventional element comprises a stent retriever.

18. The method of claim 1, wherein the interventional element comprises a thrombectomy device.

19. The method of claim 1, wherein the interventional element comprises a removal device.

20. The method of claim 1, wherein the interventional element comprises a catheter.

21. A method for thrombectomy, comprising:

positioning an interventional element proximate to a thrombus, the interventional element in electrical communication with a power source;

supplying an electrical waveform from the power source to the interventional element,

wherein the total charge supplied via the waveform is between 30-240 mC, and

wherein the waveform is supplied for no more than 2 minutes.

22. The method of claim 21, wherein a total energy delivered via the waveform is between 120-24,000 mJ.

23. The method of claim 22, wherein the total energy supplied via the waveform is between 120-5000 mJ.

24. The method of claim 21, wherein the total charge delivered via the waveform is between 30-1200 mC.

25. The method of claim 24, wherein the total charge delivered via the waveform is between 120-160 mC.

26. The method of claim 21, wherein the waveform comprises a non-square waveform.

27. The method of claim 21, wherein the waveform comprises a composite waveform including the superposition of a square waveform and a non-square waveform.

28. The method of claim 27, wherein the non-square waveform comprises a triangular waveform.

29. The method of claim 21, wherein delivering the waveform to the interventional element is not substantially thrombogenic.