SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA FOR SENSOR CALIBRATION

• US 20190320951A1
• Filed: 06/28/2019
• Published: 10/24/2019
• Est. Priority Date: 03/10/2005
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Pryor, Jack, Kamath, Apurv Ullas, Goode, JR., Paul V., Brauker, James H.
• Granted Patent: US 10,610,135 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14735 comprising an immobilised reagent
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

Claims

1-20. -20. (canceled)

21. A method of making an on-body glucose concentration measuring system comprising:

determining sensitivity calibration information for the at least one glucose sensor;

storing the sensitivity calibration information;

configuring the sensor electronics to receive sensor input signals; and

configuring a processor to use the sensitivity calibration information to calibrate received sensor input signals after implantation of the at least one sensor in a subject.

22. A method of monitoring glucose concentrations in a human subject comprising:

obtaining a short-term glucose sensing system comprising an applicator;

using the applicator to transcutaneously implant the sensor and affix the mounting unit and electronics unit to a body portion; and

using the short-term glucose sensing system to monitor glucose concentrations as measured by the sensor over the course of a sensor implanted lifespan.

23. A method of making a transcutaneous on-body glucose concentration measuring system comprising:

determining calibration information for a measuring system;

storing the calibration information;

configuring the sensor electronics to receive sensor input signals;

configuring a processor to use the calibration information to calibrate sensor signals received from the glucose sensor operably coupled to the sensor electronics after implantation of the glucose sensor in a subject.