Purifying insulin by seeding with unclumped fibrils of insulin
First Claim
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1. A METHOD OF OBTAINING INSULIN WHICH CONSISTS IN INTRODUCING INTO A SOLUTION CONTAINING INSULIN AND FOREIGN PROTEIN AND HAVING A LOW PH IN THE ACID RANGE A SEEDING MATERIAL OF UNCLUMPED INSULIN FIBRILS, MAINTAINING THE SEEDED SOLUTION FOR A TIME MUCH SHORTER THAN THAT WHICH WOULD BE REQUIRED FOR COMPLETE PRECIPITATION OF INSULIN FROM AN UNSEEDED SOLUTION AT THE TEMPERATURE OF THE SEEDED SOLUTION, WHEREBY NO MORE THAN A MINUTE AMOUNT OF COAGULATION OF FOREIGN PROTEIN OCCURS AND THE INSULIN FROM THE SOLUTION IS AGGREGATED ON THE SEEDING MATERIAL BY ELONGATION OF THE FIBRILS, AND SEPARATING THE AGGREGATED INSULIN FROM THE SOLUTION.
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1 Claim
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1. A METHOD OF OBTAINING INSULIN WHICH CONSISTS IN INTRODUCING INTO A SOLUTION CONTAINING INSULIN AND FOREIGN PROTEIN AND HAVING A LOW PH IN THE ACID RANGE A SEEDING MATERIAL OF UNCLUMPED INSULIN FIBRILS, MAINTAINING THE SEEDED SOLUTION FOR A TIME MUCH SHORTER THAN THAT WHICH WOULD BE REQUIRED FOR COMPLETE PRECIPITATION OF INSULIN FROM AN UNSEEDED SOLUTION AT THE TEMPERATURE OF THE SEEDED SOLUTION, WHEREBY NO MORE THAN A MINUTE AMOUNT OF COAGULATION OF FOREIGN PROTEIN OCCURS AND THE INSULIN FROM THE SOLUTION IS AGGREGATED ON THE SEEDING MATERIAL BY ELONGATION OF THE FIBRILS, AND SEPARATING THE AGGREGATED INSULIN FROM THE SOLUTION.
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Current AssigneeDavid F. Waugh
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Original AssigneeDavid F. Waugh
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InventorsWaugh, David F.
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Application NumberUS03/198,237Time in Patent Office986 DaysField of SearchUS Class Current530/305CPC Class CodesC07K 14/625 Extraction from natural sou...
