SURFACE OR LINING COMPATIBLE WITH BLOOD OR OTHER TISSUE

• US 3,700,380 A
• Filed: 10/01/1970
• Issued: 10/24/1972
• Est. Priority Date: 10/01/1970
• Status: Expired due to Term

• Current Assignee: Sotiris Kitrilakis
• Original Assignee: Sotiris Kitrilakis
• Inventors: Kitrilakis, Sotiris
• Primary Examiner(s): Truluck, Dalton L.
• Application Number:
  US05/077,289
• Time in Patent Office: 754 Days
• Field of Search: 128/334R,334C,348,35R,92 3/1,DIG.1,13 161/117,164
• US Class Current: 623/3.29
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61M 39/0247 Semi-permanent or permanent transcutaneous or percutaneous access sites to the inside of the body peritoneal dialysis catheters A61M1/285; tracheostomy devices A61M16/0465; measuring pressure within the body A61B5/03; colostomy devices A61F5/445; gastrotomy feeding tubes A61J15/0015; means for fixing a feeding tube outside of the body A61J15/0053
• CPC Class Codes: C08J 9/26 by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out

Abstract

A surface or lining containing microcavities for anchoring pseudointimal growth within blood handling prostheses such as vascular grafts, heart assist pumps, artificial hearts, extracorporeal devices, and the like to form a thin, stable autologous lining. The surface is also compatible with other living tissue and promotes tissue adhesion to percutaneous leads, catheters, cannulae, etc., which inhibits bacterial penetration and consequent infection. A method of forming a lining or surface containing microcavities.

Claims

1. A prosthetic device having a tissue or blood-compatible flexible surface adapted to receive ingrowth of living cells from an interfacing region of tissue or blood, said surface including a plurality of adjacent substantially discrete pockets defined by walls which extend into said surface, said pockets having openings which face outwardly in the direction of said region of tissue or blood to provide means to accommodate a number of living cells, the walls of said pockets extending inwardly to a depth in the range of .002 to .020 inches to provide anchoring but not of such shape or size as to prevent essentially normal transfer of nutrients to said living cells in said pockets from said adjacent area of tissue or blood.

2. A prosthetic device as in claim 1 in which said prosthetic device is a hollow blood handling device with said surface in contact with the blood whereby blood cells entering into said pockets are nourished from the blood adjacent said surface.

3. A prosthetic device as in claim 1 in which the entire device is flexible.

4. A prosthetic device as in claim 1 wherein said device is rigid and the surface is part of a layer applied to the device.

5. A prosthetic device as in claim 3 wherein the surface is part of a layer applied to the flexible device.

6. A prosthetic device as in claim 1 wherein said device is an elongated device with said surface on the outside adapted to penetrate the skin and receive ingrowth of cells.

7. A prosthetic device as in claim 1 wherein the size and shape of said pockets have a predetermined distribution.