COMPOSITIONS FOR TOPICAL APPLICATION FOR ENHANCING TISSUE PENETRATION OF PHYSIOLOGICALLY ACTIVE AGENTS WITH DMSO

• US 3,711,602 A
• Filed: 10/30/1970
• Issued: 01/16/1973
• Est. Priority Date: 10/30/1970
• Status: Expired due to Term

• Current Assignee: Gay Lord Container Corporation (International Paper Company)
• Original Assignee: Robert John Herschler
• Inventors: Herschler, Robert John
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/085,697
• Time in Patent Office: 809 Days
• Field of Search: 424/45,337
• US Class Current: 424/45
• CPC Class Codes: A61K 47/20 containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00

Abstract

Compositions for topical application for enhancing tissue penetration of physiologically active agents with dimethyl sulfoxide (DMSO). Such agents include physiologically active steroids, antineoplastic agents, antigens, antihistaminic agents, neuropharmacologic agents, antiinflammatory agents, anticoagulants, vasodilators, ultra-violet screening agents and nutrients. Such compositions, which may be in the form of lotions, ointments and suppositories, include the physiologically active agent, at least 10% by weight of DMSO and a pharmaceutically acceptable thickening agent. Liquid formulations for topical application of DMSO and the physiologically active agent in spray containers are also provided.

Claims

2. A composition as in claim 1 for dermal application and wherein said DMSO comprises at least about 50 percent by weight of said composition.

3. A composition as in claim 2 and wherein said agent is selected from the group consisting of physiologically active steroids, antineoplastic agents, antigens, antihistaminic agents, analgesics, local anaesthetics and antiinflammatory agents.

4. A composition as in claim 1 and wherein said composition is in the form of a lotion.

5. A composition as in claim 1 and wherein said composition is in the form of an ointment.

6. A composition as in claim 1 and wherein said composition is in the form of a suppository.

7. A container provided with liquid spray dispensing means and containing a fluid, sprayable composition which comprises an amount of a physiologically active agent effective to produce the desired physiological effect on topical application of the composition to an external membrane of a human or animal, said agent being selected from the group consisting of physiologically active steroids, antineoplastic agents, antigens, antihistaminic agents, neuropharmacologic agents, antiinflammatory agents, anticoagulants, vasodilators, ultra-violet screening agents and nutrients, and an amount of DMSO effective to enhance external membrane penetration of said agent and comprising at least about 10 percent by weight of said composition.

8. A container as in claim 7 and wherein said DMSO in the composition charged therein comprises at least about 50 percent by weight of said composition.

9. A container as in claim 7 and wherein said container is an aerosol bomb containing a halocarbon propellant.

10. A container as in claim 7 and wherein said container is a squeeze bottle.

11. A container as in claim 7 and wherein the composition therein contains a substantial amount of water as a diluent.