CERTAIN DILIOWERALKYLAMINO-METHYLENE(OR ETHYLENE)-2(IH)PYRIDONES

• US 3,853,896 A
• Filed: 06/25/1971
• Issued: 12/10/1974
• Est. Priority Date: 06/25/1971
• Status: Expired due to Term

• Current Assignee: Arsenio A. Pessolano, Bruce E. Witzel, Patricia M. Graham, Robert L. Clark, Tsung-Ying Shen
• Original Assignee: Arsenio A. Pessolano, Bruce E. Witzel, Patricia M. Graham, Robert L. Clark, Tsung-Ying Shen
• Inventors: Pessolano, Arsenio A., Witzel, Bruce E., Graham, Patricia M., Clark, Robert L., Shen, Tsung-Ying
• Primary Examiner(s): Rotman, Alan L.
• Application Number:
  US05/156,919
• Time in Patent Office: 1,264 Days
• Field of Search: 260/296R
• US Class Current: 546/300
• CPC Class Codes: C07D 213/64 attached in position 2 or 6
• CPC Class Codes: C07D 215/227 only one oxygen atom which is attached in position 2
• CPC Class Codes: C07D 215/26 Alcohols; Ethers thereof
• CPC Class Codes: C07D 215/32 Esters
• CPC Class Codes: C07D 215/36 Sulfur atoms C07D215/24 takes precedence
• CPC Class Codes: C07D 215/40 attached in position 8
• CPC Class Codes: C07D 221/04 Ortho- or peri-condensed ring systems

Abstract

Novel process for preparing pyridones via a nucleophilic substitution side chain reaction of halo-pyridones. The novel pyridones disclosed herein are potent anti-inflammatory, analgesic and anti-pyretic agents. Also included are pharmaceutical compositions containing said pyridones as active ingredients and the methods of treating painful, inflamed and fever states in patients by administering said compounds.

Claims

1. A COMPOUND OF THE FORMULA:

2. The compound of claim 1 wherein R1 is hydrogen;

R2 is dimethylamino;

x is 0;

s is 0;

p is 0; and

p1 is 1.

3. The compound of claim 1 wherein R1 is hydrogen;

R2 is dimethylamino;

x is 0;

p is 1;

p1 is 0 and S is 1.

4. The compound of claim 1 wherein R1 is methyl;

R2 is dimethylamino;

p is 1;

p1 is 0;

s is 0; and

x is 0.

5. The compound of claim 1 wherein R1 is methyl;

R2 is dimethylamino;

p is 0;

P1 is 1;

s is 0; and

x is 0.

6. The compound of claim 1 wherein R1 is hydrogen;

R2 is dimethylamino;

R3 is methyl;

p is 0;

p1 is 1;

s is 1; and

x is 2.

7. The compound of claim 1 wherein R1 is hydrogen;

R2 is dimethylamino;

R3 is methyl;

p is 1;

p1 is 0;

s is 1 and x is 1.

8. The compound of claim 1 wherein R1 is methyl;

R2 is dimethylamino;

s is 0;

p is 0;

p1 is 1; and

x is 2.

9. The compound of claim 1 wherein R1 is methyl;

R2 is dimethylamino;

s is 0;

p is 1;

p1 is 0; and

x is 2.