Thyroxine-and triiodothyronine-tyrosine dipeptide derivatives
First Claim
1. A compound of the formula ##SPC4##whereinX is H, I, 125 I, or 131 I,R is a group selected from the group consisting of ##EQU1## wherein R°
- is an alkyl group, and b. an alkylene group,Y is H;
125 I, or 131 I, andZ is H;
125 I, or 131 I.
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention is concerned with the production of novel derivatives of thyroid hormones which are useful in the radioimmunoassay (RIA) of such hormones. The invention is particularly concerned with derivatives of thyroxine and triiodothyronine which contain an additional phenol group which is readily iodinatable so that the phenol conjugate can be readily tagged with a radioactive iodine isotope, such as 125 I or 131 I, without detrimentally interfering with the ability of the tagged conjugate so competitively bind with the naturally occurring thyroid hormone in the biological liquid to be analyzed by RIA technique. The invention is also concerned with the iodine-tagged derivatives or conjugates.
12 Citations
8 Claims
-
1. A compound of the formula ##SPC4##
wherein X is H, I, 125 I, or 131 I, R is a group selected from the group consisting of ##EQU1## wherein R° - is an alkyl group, and b. an alkylene group,
Y is H;
125 I, or 131 I, andZ is H;
125 I, or 131 I. - View Dependent Claims (2, 3, 4, 5, 7, 8)
- is an alkyl group, and b. an alkylene group,
-
6. A compound according to claim 6 wherein at least one of the Y and Z
Specification
-
- Resources
-
Current AssigneeICN Micromedic Systems Incorporated
-
Original AssigneeMicromedic Diagonistics Incorporated
-
InventorsNiswender, Gordon Dean
-
Primary Examiner(s)Gotts, Lewis
-
Assistant Examiner(s)Suyat, Reginald J.
-
Application NumberUS05/559,862Time in Patent Office559 DaysField of Search260/112.5 R, 260/559 A, 424/177US Class Current560/39CPC Class CodesC07K 5/06191 containing heteroatoms diff...G01N 33/78 Thyroid gland hormones , e....
