Apparatus and method for implanted self-powered medication dispensing

• US 4,003,379 A
• Filed: 09/24/1975
• Issued: 01/18/1977
• Est. Priority Date: 04/23/1974
• Status: Expired due to Term

• Current Assignee: Biomedical Systems Institute Incorporated
• Original Assignee: Everett H. Ellinwood Jr
• Inventors: Ellinwood, Everett H. Jr.
• Primary Examiner(s): Medbery, Aldrich F.
• Application Number:
  US05/616,294
• Time in Patent Office: 482 Days
• Field of Search: 128/260, 128/218 A, 128/214 F, 128/DIG. 1, 128/DIG. 13, 128/214 E, 128/213, 128/2 R
• US Class Current: 604/891.1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats
• CPC Class Codes: A61M 2205/3507 with implanted devices, e.g. external control
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 5/1001 using radiation sources introduced into or applied onto the body; brachytherapy
• CPC Class Codes: Y10S 128/01 Motorized syringe

Abstract

An apparatus for dispensing drugs and other medications within the body leaves the patient ambulatory and is adapted to be entirely implanted and to dispense such substances over a long period of time, e.g., one to several years, in accordance with the actual needs of the patient. A self-powered dispensing device stores a single or plural substances in powdered, liquid, or other dispensable form and utilizes a compressible container, i.e., a bellows, for withdrawing such substances from storage and dispensing to the body. The dispensing operation may be on a fixed schedule or may be controlled by monitoring single or plural sensors implanted in the body and evaluating the sensed data in order to control both the conditions under which and the kind of dispensing which takes place. Dual dispensers and dual medication may be employed.

Claims

1. A self-contained and powered implant apparatus adapted to be totally received within a selected animal body, including human, for periodically dispensing selected medication therein while leaving the body ambulatory at all times, comprising:

a. a unitary housing adapted to be completely implanted and secured within and to the body at a selected site and having therein various compartments enclosed by said housing and adapted for mounting a medication storage member, a micro size power source, miniaturized electro-mechanical driving and dispensing means adapted to being powered by such source for dispensing medication from such storage member and electrical means for connecting the driving means to the source so as to operate the dispensing means on a schedule according to the needs of said body for medication;

b. a storage member mounted within the implanted housing for storing selected medication to be dispensed in selected quantities;

c. a micro size power source mounted within the implanted housing and secured proximate said storage member and having a useful working life in terms of at least several days;

d. miniaturized electro-mechanical driving means mounted within the implanted housing selectively connected to and powered by said source;

e. miniaturized dispensing means mounted within the implanted housing and having a retractable flexible walled container means with an inlet connected to receive medication from said storage member and connected for being powered by said driving means and when so powered and when expanded, receiving from said storage member through said inlet and into said container means successive measured quantities of selected said medication and having an outlet means for enabling discharge of such medication from said container means through the wall of the implanted housing and into said body during compression of said container means; and

f. electrical means mounted within the implanted housing for providing an electrical connection between said power source and said driving means for driving, energizing and actuating said dispensing means including said container means on a controlled schedule in coordination with the medical needs of the body.

2. An apparatus as claimed in claim 1 including one-way valve means associated with each respective said inlet and outlet and operable in coordination with operation of said container means.

3. An apparatus as claimed in claim 1 wherein said container means comprises a single bellows type container means.

4. An apparatus as claimed in claim 1 including externally available portal means in said housing adapted for replenishing medication in said storage member.

5. An apparatus as claimed in claim 1 wherein said container means outlet includes a discharge port and externally accessible portal means enabling the entry of a suitable tool to clean said discharge port.

6. An apparatus as claimed in claim 1 including externally available portal means in said housing adapted for replenishing medication in said storage member wherein said container means outlet includes a discharge port and externally accessible portal means enabling the entry of a suitable tool to clean said discharge port.

7. An apparatus as claimed in claim 1 wherein said container means comprises a dual bellows type container means with a common said driving means and with each member of the dual container means having a respective said inlet and outlet.

8. An apparatus as claimed in claim 4 wherein the members of the dual container means are sized for different size dosages.

9. An apparatus as claimed in claim 4 including one-way valve means associated with each respective said inlet and outlet and operable in coordination with operation of said container means.

10. An apparatus as claimed in claim 1 wherein said driving means comprise dual driving means and said container means comprise dual container means each having an associated said driving means and with each container means having a separate said inlet connection to said storage member and a separate said outlet connection through the wall of said implanted housing and said electrical means includes means for connecting each respective driving means to said power source on a schedule according to the medical needs of said body.

11. An apparatus as claimed in claim 10 wherein said respective container means are sized to measure different size dosages of said medication.

12. An apparatus as claimed in claim 10 including one-way valve means associated with each respective said inlet and outlet and operable in coordination with operation of said container means.

13. An apparatus as in claim 10 wherein one of said driving means is adapted for relatively fast actuation of its respective associated container means to effect relatively quick dispensing of a dosage and the other of said driving means is adapted for relatively slow actuation of its respective said container means to effect relatively slow dispensing of a dosage.

14. An apparatus as claimed in claim 13 wherein said relatively fast actuated driving means is of a solenoid type and said relatively slow actuated means is of a revolving cam type.

15. An apparatus as claimed in claim 1 wherein said storage member includes two compartments each with a storage of medication, said container means and driving means comprise dual container means with respective said inlets and outlets and with each container means having an associated driving means and said electrical means including means for connecting each respective driving means to said power source such that each medication in each compartment can be dispensed through its own respective container means and on its own schedule coordinated with the medical needs of said body.

16. An apparatus as in claim 15 wherein said respective container means are sized to measure different size dosages of the respective said medications.

17. An apparatus as in claim 15 wherein one of said driving means is adapted for relatively fast actuation of its respective associated container means to effect relatively quick dispensing of a dosage and the other of said driving means is adapted for relatively slow actuation of its respective said container means to effect relatively slow dispensing of a dosage.

18. An apparatus as claimed in claim 17 wherein said relatively fast actuated driving means is of a solenoid type and said relatively slow actuated means is of a revolving cam type.

19. An apparatus as claimed in claim 15 including one-way valve means associated with each respective said inlet and outlet and operable in coordination with operation of said container means.

20. The method of utilizing the apparatus of claim 1 of periodically dispensing medication in said body according to its needs while leaving the body ambulatory at all times, comprising the steps:

a. implanting the housing of said apparatus in the body at a selected site and with a store of selected medication; and

b. allowing said medication to be dispensed through said container means in successive measured dosages drawn into and discharged therefrom to a selected site within the body on a schedule controlled by said electrical means and over a long period of time.

21. The apparatus of claim 1 wherein said dispensing means is adapted for receiving interchangeable said container means enabling said measured quantities to be varied according to medication needs.

22. An apparatus adapted to be totally received within a selected animal body, including human, for periodically dispensing selected medication therein while leaving the body ambulatory at all times, comprising:

a. a storage member mounted within implanted housing means for storing selected medication to be dispensed in selected quantities;

b. a micro size power source mounted within implanted housing means and having a useful working life in terms of at least several days;

c. miniaturized electro-mechanical driving means mounted within implanted housing means and selectively connected to and powered by said source;

d. miniaturized dispensing means mounted within implanted housing means and having expandable - contractible flexible walled container means with an inlet connected to receive medication from said storage member and connected for being powered by said driving means for contraction and expansion operations and when expanding to receive from said storage member through said inlet and into said container means successive measured quantities of selected medication and having an outlet means for enabling discharge of such medication from said container means into said body during contracting of said container means; and

e. electrical means mounted within implanted housing means for providing an electrical connection between said power source and said driving means for driving, energizing and actuating said dispensing means including said container means on a controlled schedule in coordination with the medical needs of the body.