Blood glucose control apparatus
First Claim
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1. Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon both the particular concentration of glucose in said blood stream and the rate of change of said blood glucose concentration comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values;
- computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and
pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals;
said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU5## wherein IR = calculated insulin infusion rateBI = basal glucose concentrationRI = desired basal insulin infusion rate at BIg = measured previous serial blood glucose reading and BI, RI, and QI are preselected values and wherein if the blood glucose concentration is rising
space="preserve" listing-type="equation">GD =(K.sub.R A.sup.2
10) + 6Awherein A is the average change in blood gulcose concentration over several previous serial readings and KR is a preselected value and wherein if the blood glucose concentration is falling
space="preserve" listing-type="equation">GD = (K.sub.F A.sup.2
10) + 6Awherein A is the same as above and KF is a preselected value which is different from and less than KR, said GD being substracted from G in the above equation when the blood glucose concentration is falling.
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Abstract
Apparatus is described for controlling blood glucose concentration in a subject by selected infusion of insulin and/or glucose, depending upon the general blood glucose concentration. This apparatus comprises in combination sensor means for measuring the blood glucose concentration and for providing computer input signals based on such measurement, computer means for receiving such input signals and being programmed to provide output signals based upon such input signals, and pump means responsive to such computer output signals to supply insulin and/or glucose to such subject at a rate determined by such output signals. The computer derives the output signals in accordance with specific quadratic and biquadratic equations employing certain independently selected values relating to basal blood glucose concentrations and basal insulin and glucose infusion rates at such basal blood glucose concentrations.
1088 Citations
8 Claims
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1. Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon both the particular concentration of glucose in said blood stream and the rate of change of said blood glucose concentration comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values;
- computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and
pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals;
said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU5## wherein IR = calculated insulin infusion rateBI = basal glucose concentration RI = desired basal insulin infusion rate at BI g = measured previous serial blood glucose reading and BI, RI, and QI are preselected values and wherein if the blood glucose concentration is rising
space="preserve" listing-type="equation">GD =(K.sub.R A.sup.2
10) + 6Awherein A is the average change in blood gulcose concentration over several previous serial readings and KR is a preselected value and wherein if the blood glucose concentration is falling
space="preserve" listing-type="equation">GD = (K.sub.F A.sup.2
10) + 6Awherein A is the same as above and KF is a preselected value which is different from and less than KR, said GD being substracted from G in the above equation when the blood glucose concentration is falling.
- computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and
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2. Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon the particualr concentration of glucose in said blood stream comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values;
- computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and
pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals;
said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU6##wherein
- computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and
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3. IR = calculated insulin infusion rate
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4. BI = basal glucose concentration
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5. RI = desired basal insulin infusion rate at BI
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6. G = measured previous glucose reading and BI, RI and QI are preselected values.
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7. Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of insulin to such subject dependent upon the rate of change of glucose concentration in said blood stream comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values;
- computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and
pump means responsive to said output signals for supplying insulin to such subject at a rate determined by said output signals;
said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU7## wherein IR = calculated insulin infusion rateBi = basal glucose concentration RI = desired basal insulin infusion rate at BI g = measured previous glucose reading and BI, RI and QI are preselected values and wherein if the blood glucose concentration is rising
space="preserve" listing-type="equation">GD = (K.sub.R A.sup.2
10) = 6Awherein A = the average change in blood concentration over several previous serial readings and KR is a preselected value and wherein if the blood glucose concentration is falling
space="preserve" listing-type="equation">GD = (K.sub.F A.sup.2
10) = 6Awherein A is the same as above and KF is a preselected value which is different from and less than KR, said GD being substracted from G in the above equation when the blood glucose concentration is falling.
- computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and
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8. Apparatus for controlling the concentration of glucose in the blood stream of a subject by controlled supply of glucose to such subject dependent upon the particular concentration of glucose in said blood stream comprising means for determining serial values of blood glucose concentration and for providing computer input signals corresponding to said serial values;
- computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and
pump means responsive to said output signals for supplying glucose to such subject at a rate determined by said output signals;
said computer being capable of deriving output signals from serial input signals in accordance with an equation of the form ##EQU8##wherein DR = calculated glucose infusion rateBD = basal glucose concentration RD = desired basal glucose infusion rate at BD g = measured previous glucose reading and BD, RD and QD are preselected values.
- computer means coupled to receive said serial input signals, said computer means being programmed to provide output signals based upon said serial input signals; and
Specification
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Current AssigneeMiles Laboratories, Inc. (Bayer AG)
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Original AssigneeMiles Laboratories, Inc. (Bayer AG)
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InventorsClemens, Anton Hubert, Myers, Robert Weston
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Primary Examiner(s)Kamm, William E.
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Application NumberUS05/685,881Time in Patent Office536 DaysField of Search128/2 E, 128/2 R, 128/2.1 E, 128/2.1 R, 128/213, 128/214, 128/260, 204/195 B, 235/151.3US Class Current604/66CPC Class CodesA61B 5/14532 for measuring glucose, e.g....A61M 5/1723 using feedback of body para...
