Portable chemical reactor for use as an artificial kidney

• US 4,071,444 A
• Filed: 10/12/1976
• Issued: 01/31/1978
• Est. Priority Date: 10/12/1976
• Status: Expired due to Term

• Current Assignee: HemoCleanse, Inc.
• Original Assignee: Purdue Research Foundation (The Trustees of Purdue University (d/b/a Purdue University))
• Inventors: Ash, Stephen R., Wilcox, Philip G., Kessler, David P.
• Primary Examiner(s): Spear, Jr., Frank A.
• Application Number:
  US05/731,826
• Time in Patent Office: 476 Days
• Field of Search: 210/321 B, 210/22, 210/232, 128/214 R
• US Class Current: 210/637
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/267 used for pumping
• CPC Class Codes: A61M 1/304 Treatment chamber used as reservoir, e.g. centrifuge bowl or filter with movable membrane
• CPC Class Codes: A61M 1/3475 with filtrate treatment agent in the same enclosure as the membrane
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: B01D 2321/168 Use of other chemical agents
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01D 65/08 Prevention of membrane fouling or of concentration polarisation

Abstract

A small, portable, chemical reactor adapted to tap the venous blood supply of a patient, said device including a stack of semi-permeable membranes blood and dialysis materials in alternate chambers, said stack being held in sealed relationship by a single center bolt which facilitates quick assembly and disassembly.

Claims

1. A dialysis device, comprising a sealed outer casing which is divided internally by at least one flexible membrane into at least one chamber adapted to receive blood, and at least one other chamber adapted to receive dialysis material,

a blood flow passage directly connected to said one chamber to provide blood flow in one direction into said one chamber through said blood passage and to provide blood flow in the opposite direction away from said one chamber through said blood passage,

pressure control means connected to said other chamber,

whereby decreasing the pressure in said other chamber causes blood to be drawn into said one chamber through said blood passage, and increasing the pressure in said other chamber causes blood to be forced out of said one chamber through said blood passage.

2. The device of claim 1 in which said blood flow passage is connectable with a single venous blood access to a patient, and wherein said pressure control means exerts low pressure sufficient to provide slow blood treatment of a patient connected with said device through said single venous blood access.

3. A dialysis device comprising:

a top plate and a bottom plate having central apertures therein;

at least one peripheral spacer having a solid peripheral portion and a hollow central portion;

at least two semi-permeable flexible membranes having central apertures therein;

central gasket and spacer means having a bore therein;

a bolt having compression means thereon to clamp said top and bottom plate therebetween, said bolt being sized to fit in the bore of said central gasket and spacer means;

said flexible membranes being captured in sealing relationship at their outer peripheries between said top and bottom plates with said peripheral spacer therebetween, and being captured in sealing relationship at their central aperture with said central gasket and spacer means therebetween upon insertion of said bolt in the central aperture of said plates, gasket and spacer means and membranes and the tightening of said compression means on said bolt, such that the gasket and spacer means, and the top and bottom plates, and peripheral spacer are all placed in compression by said compression means on said bolt with a sealed chamber being thereby formed for receiving fluid in direct contact with said membrane; and

passage means for providing a single fluid path both to and away from said chamber and through which fluid is conducted into said chamber and from which fluid is conducted away from said chamber.

4. The device according to claim 3 in which said membranes have a plurality of striations therein.

5. A method of operating a dialysis apparatus having adjacent resilient semi-permeable membranes forming at least two chambers within a casing, one of said chambers being charged with blood inflow and providing blood outflow through a single passage and another adjacent chamber being charged with dialysate material, which method comprises:

alternately lowering and increasing the pressure in said dialysate chamber thereby first expanding the blood chamber to draw in a small amount of blood for dialysis through said single passage, and then expelling the dialyzed blood from the blood chamber through said single passage whereby slow blood treatment is steadily achieved.

6. The process according to claim 5 in which the blood in introduced into and expelled from said chamber through a centrally located passage.

7. A chemical reactor device for hemodialysis in which at least two semi-permeable elastic membranes are disposed between annular rings at the outer periphery of the membranes, at least one central spacer disc having a diameter substantially less than said annular rings, with said spacer disc including passage means to permit blood flow therethrough to and from a first chamber between said membranes, said device also including a single passage for conducting blood to and from said first chamber through said spacer disc, and said device also including a top disc and a bottom disc which, together with said membranes, define a second chamber, said second chamber having passage means communicating therewith to the exterior of said device whereby the contents of said second chamber, and hence pressure therein, may be controlled from the device exterior independently of said passage means in the central spacer disc.

8. The device according to claim 7 in which the device includes a central bore extending through said top and bottom discs, said membranes and said spacer disc including blood passage means, said bore being sized to receive a bolt in said bore with said bolt having said single passage therein to provide for said interior blood passage, said bolt also having at least one port therein between said single passage and its outer surface, said bolt port being in communication with the blood passage means of said spacer disc whereby blood may be admitted from the exterior of the device into the said first chamber of the device through said single passage and withdrawn from said chamber and conducted to the exterior of said device through said single passage.

9. The device according to claim 8 in which said bolt has a head of larger diameter than the said central bore of the device at one end, and said bolt being adapted at its other end to receive a compression type fastener, a compression fastener on the end of said bolt adapted to receive it whereby, upon tightening said fastener, compression forces are exerted both on said spacer disc, top and bottom plates and annular rings such that the said membranes are captured therebetween and sealed.

10. A chemical reactor device for hemodialysis in which at least two semi-permeable elastic membranes are disposed between a peripheral spacer at the outer periphery of the membranes and at least one central spacer, said central spacer having passage means to permit blood flow therethrough to and from a first chamber between said membranes, and said membranes having striations therein with said membranes being closely positioned with respect to one another and being oriented so that said striations facilitate blood flow from said central spacer toward the outer periphery of the chamber, said device also including means which, together with said membranes, define a second chamber receiving dialysate material in contact with said membranes at the side thereof opposite to that in contact with said blood spread through said first chamber.

11. The device according to claim 10 in which the membrane striations are arranged at right angles to one another between adjacent membranes whereby uniform blood flow is permitted.