Cephalosporin antibiotics

• US 4,128,715 A
• Filed: 04/27/1977
• Issued: 12/05/1978
• Est. Priority Date: 04/28/1976
• Status: Expired due to Term

• Current Assignee: Glaxo Laboratories Limited (GlaxoSmithKline PLC)
• Original Assignee: Glaxo Laboratories Limited (GlaxoSmithKline PLC)
• Inventors: Sharp, Christopher J.
• Primary Examiner(s): Rizzo, Nicholas S.
• Application Number:
  US05/791,529
• Time in Patent Office: 587 Days
• Field of Search: 260/243 C, 544/22
• US Class Current: 540/222
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/545 Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins, cefaclor, or cephalexine
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

A special crystalline form of the L-lysine salt of the antibiotic cefuroxime is described. The salt has improved properties that permit it to be used in areas where cefuroxime itself and known derivatives of cefuroxime cannot be used.

Claims

1. The crystalline form of L-lysine salt of cefuroxime characterised by the following X-ray diffraction data:

space="preserve" listing-type="tabular">______________________________________ Line d Relative Line d Relative number (A) Intensity number (A) Intensity ______________________________________ 1 13.59 100 19 3.26 12 2 10.46 80 20 3.18 12 3 9.18 16 21 3.06 19 4 8.40 75 22 2.97 10 5 6.88 56 23 2.82 14 6 6.31 16 24 2.78 7 7 5.80 2 25 2.69 4 8 5.48 6 26 2.64 17 9 5.23 14 27 2.47 6 10 4.79 52 28 2.38 8 11 4.74 40 29 2.32 6 12 4.58 16 30 2.25 9 13 4.41 76 31 2.03 4 14 4.11 40 32 1.99 2 15 3.98 52 33 1.95 1 16 3.82 16 34 2.10 1 17 3.61 71 35 1.90 4 18 3.42 17 36 1.81 5 ______________________________________