Method for determining the contents of metabolic products in the blood

• US 4,169,676 A
• Filed: 02/17/1977
• Issued: 10/02/1979
• Est. Priority Date: 02/20/1976
• Status: Expired due to Term

• Current Assignee: Nils Kaiser
• Original Assignee: Nils Kaiser
• Inventors: Kaiser, Nils
• Primary Examiner(s): Marcus, Michael S.
• Application Number:
  US05/769,777
• Time in Patent Office: 957 Days
• Field of Search: 23/230 B, 23/230 R, 250/341, 356/39, 128/2 A
• US Class Current: 356/39
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: G01N 21/552 Attenuated total reflection
• CPC Class Codes: Y10T 436/144444 Glucose
• CPC Class Codes: Y10T 436/204165 Ethanol

Abstract

A method and instrument for determining the amounts of metabolic products in blood using a laser beam guided through an ATR plate placed against a blood supplied biological tissue. The intensity of the beam is then detected after being affected by the blood containing the metabolic elements and is used to determine the amounts of metabolic products in the blood.

Claims

1. A method of determining the amounts of metabolic products in blood comprising the steps of placing an ATR plate against a living blood supplied living biological tissue, guiding a laser beam through said ATR plate, and detecting the intensity of said beam after being affected by the blood containing the metabolic elements.

2. The method as defined in claim 1 which includes the step of reflecting said beam from 2 to 14 times at the surface to the boundary region of which the blood is brought.

3. The method as defined in claim 1 wherein said laser beam has an angle of incidence from 45°

to 60°

with respect to the surface of the ATR plate at the boundary surface region of which the blood is brought.

4. The method as defined in claim 2 which includes the step of reflecting said beam from six to fourteen times at the surface to said boundary region.

5. The method as defined in claim 3 wherein said angle of incidence is about 50°

.

6. A method of determining the amounts of metabolic products in blood comprising the steps of placing a first ATR plate against a surface of a living blood supplied being biological tissue and a second ATR plate against a reference solution lacking said metabolic products, splitting a laser beam from a single infrared laser into first and second partial beams of the same wavelength, guiding said first and second partial beams through said first and second ATR plates, respectively, and detecting the difference in intensity of said partial beams.

7. The method as defined in claim 6, wherein said reference solution is distilled water.

8. The method as defined in claim 6 which includes the steps of chopping said first and second partial beams into alternating light of different frequencies before said partial beams are guided through said ATR plates.

9. The method as defined in claim 8 which includes the step of recombining said partial beams into a single beam after passage through said ATR plates, said detecting step detecting the difference in intensities of the light at said different frequencies in said single beam.