Enzymatic dentifrices

• US 4,178,362 A
• Filed: 11/09/1978
• Issued: 12/11/1979
• Est. Priority Date: 06/03/1969
• Status: Expired due to Term

• Current Assignee: Telec SA (Barco NV)
• Original Assignee: Telec SA (Barco NV)
• Inventors: Moelker, Huibert C. T., Hoogendoorn, Hendrik, Matthijsen, Rutger
• Primary Examiner(s): Rose, Shep K.
• Application Number:
  US05/959,162
• Time in Patent Office: 397 Days
• Field of Search: 424/48, 424/50, 424/94, 426/3
• US Class Current: 424/48
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/66 Enzymes
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

A novel enzymatic dentifrice comprises as its essential active ingredient an amount of glucose oxidane enzyme which forms hydrogen peroxide by oxidative decomposition of a glucose substrate provided by glucose present in saliva and tooth plaque so as to cause a substantial shift toward neutral values in the pH at the surface of teeth, when said pH is below the neutral range.

Claims

1. An enzyme dentifrice chewing gum or tablet consisting of about 0.5 to about 20 units per gram/milliliter of glucose oxidase enzyme which forms hydrogen peroxide by oxidative decomposition of a glucose substrate provided by glucose present in sufficient amount in saliva and tooth plaque, said hydrogen peroxide being formed in a continuous concentration no greater than 10^-4 %, said unit being the quantity of the enzyme which will oxidize 1 micromol of substrate per minute at 30°

C. and pH 6, effective when applied to a dental surface exhibiting a pH below the neutral range, to restore the pH at said dental surface to an approximately neutral range, and

a pharmaceutically acceptable carrier.

2. The enzyme dentifrice of claim 1 wherein the concentration of hydrogen peroxide is insufficient to inhibit the saliva enzyme lactoperoxidase required for oxygen transfer from peroxide to oral bacteria cells, and thereby to accomplish bacterial inactivation by hydrogen peroxide, which, if otherwise present in high or moderate concentrations, inhibits the lactoperoxidase, no oxygen transfer to oral bacterial cells takes place, and no oral bacteria inactivation is accomplished.

3. The composition of claim 1 which includes a carbohydrase.

4. The composition of claim 3 in which said carbohydrase is amyloglucosidase.

5. The composition of claim 3 in which the amount by weight of said carbohydrase is from about 1 to about 8 times the amount of glucose hydrase.

6. The method of cleaning a dental surface and suppressing the formation of dental plaque thereon which comprises applying to said dental surface an enzymatic dentifrice, according to claim 1.

7. The method of cleaning a dental surface and suppressing the formation of dental plaque thereon which comprises applying to said dental surface an enzymatic dentifrice according to claim 1.