Liquid transport device and method

• US 4,233,029 A
• Filed: 10/25/1978
• Issued: 11/11/1980
• Est. Priority Date: 10/25/1978
• Status: Expired due to Term

• Current Assignee: Clinical Diagnostic Systems Inc.
• Original Assignee: Eastman Kodak Company
• Inventors: Columbus, Richard L.
• Primary Examiner(s): Turk, Arnold
• Application Number:
  US05/954,689
• Time in Patent Office: 748 Days
• Field of Search: 356/244, 23/230 R, 422/55, 422/56, 422/57, 422/58, 422/68, 422/100, 204/195 R, 204/195 M
• US Class Current: 436/174
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/089 Virtual walls for guiding liquids
• CPC Class Codes: B01L 2300/166 Suprahydrophobic; Ultraphobic; Lotus-effect
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/086 using baffles or other fixed flow obstructions
• CPC Class Codes: B01L 3/50273 characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/502746 characterised by the means for controlling flow resistance, e.g. flow controllers, baffles B01L3/502738 takes precedence
• CPC Class Codes: G01N 1/28 Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Qmounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 ; laboratory gas handling apparatus B01L5/00
• CPC Class Codes: Y10T 436/25 including sample preparation

Abstract

A liquid transport device and method are disclosed, for controlled liquid flow. The device contains opposed surfaces providing a controlled capillary flow zone, each surface including means for directing flow along predetermined paths and at least one surface including means to permit liquid introduction between the surfaces. At least a portion of the paths of one surface form a positive angle with respect to the paths of the directly opposing portion of the other surface, whereby controlled multidirectional flow of liquid introduced between the surfaces occurs with a predetermined peripheral configuration.

Claims

1. A liquid transport device for controlled fluid flow comprising

two fixedly mounted opposing surface areas substantially all portions of which are spaced apart throughout a zone of intended liquid transport a distance no greater than will maintain a capillary flow of liquid introduced therebetween, and means to permit the introduction of liquid between said surfaces,

each of said surfaces including, across at least a portion thereof, means for directing capillary flow of introduced liquid along predetermined paths, said directing means on the respective surfaces being relatively oriented so that the paths directed by a substantial portion of one of said surfaces form positive angles with respect to the paths directed by the directly opposing portion of the other surface,

whereby capillary flow of liquid between said surfaces occurs in a controlled multidirectional manner with a predetermined peripheral configuration.

2. A device as defined in claim 1, wherein at least one of said surfaces is formed of a material that is substantially impervious to the introduced liquid.

3. A device as defined in claim 1, wherein both of said surfaces are formed of material that is substantially impervious to the introduced liquid.

4. A device as defined in claim 1 wherein said directing means of each of said surfaces comprises a pattern of exposed grooves.

5. A device as defined in claim 4, wherein said grooves of at least one of said surfaces are substantially straight and parallel across said surface portion, whereby a substantially linear wave front is formed between said surfaces as the introduced liquid advances across said straight grooves.

6. A device as defined in claim 4, wherein said grooves of both of said surfaces are substantially straight and parallel, and wherein said angles are about 90°

, whereby liquid introduced between said surfaces advances as at least two generally perpendicular linear wave fronts.

7. A device as defined in claim 4, wherein said grooves of one of said surfaces are curvilinear and substantially parallel, whereby liquid introduced between said surfaces advances as a curvilinear wave front.

8. A device as defined in claim 4, wherein said grooves are separated by ridges and the top portions of the ridges of one of said surfaces are spaced from the top portions of the ridges of the other surface.

9. A device as defined in claim 4, wherein said grooves are separated by ridges and the top portions of the ridges of one of said surfaces are in contact with the top portions of the ridges of the other surface.

10. A device as defined in claim 4, wherein the the grooves of one of the surfaces have smaller cross-sectional areas, transverse to flow along their length, than the grooves of the other surface to provide preferential flow in the direction of the grooves of said one surface.

11. A passive liquid spreading device for controlled fluid flow comprising

two opposed generally coplanar surfaces substantially all portions of which are fixedly spaced apart throughout a zone of intended liquid transport a distance no greater than that effective to induce capillary flow of an introduced liquid, and access means to permit the introduction of liquid between said surfaces,

said surfaces each including, across at least portions thereof, a plurality of exposed grooves formed in a predetermined pattern, at least a substantial portion of said grooves of one of said surfaces being disposed at positive angles with respect to the directly opposed grooves of the other surface to controllably induce the menisci of liquid introduced between said surfaces to advance with a predetermined peripheral configuration.

12. A device as defined in claim 11, wherein said grooves of at least one of said surfaces are substantially straight and parallel across said surface portion, whereby a substantially linear wave front is formed between said surfaces as introduced liquid advances across said straight grooves.

13. A device as defined in claim 11, wherein said grooves of both of said surfaces are substantially straight and parallel, and wherein said angles are about 90°

, whereby liquid introduced between said surfaces advances as at least two generally perpendicular linear wave fronts.

14. A device as defined in claim 11, wherein said grooves of one of said surfaces are curvilinear and substantially parallel, whereby liquid introduced between said surfaces produces a curvilinear wave front.

15. A device as defined in claim 11, wherein at least one of said surfaces is formed of a material that is substantially impervious to the introduced liquid.

16. A device as defined in claim 11, wherein said access means comprises an aperture in at least one of said surfaces.

17. A device for controlled distribution of liquid across a zone of intended liquid transport by means of induced capillary forces, said device comprising

two surfaces respectively having fixedly mounted opposing surface areas substantially all portions of which are spaced throughout a transport zone a distance no greater than that effective to induce capillary flow and to define said transport zone, and access means to permit the introduction of liquid into said zone,

each of said surface areas having a plurality of grooves constructed in a predetermined pattern, a substantial portion of the grooves of one surface area forming positive angles with respect to the directly opposed grooves of the other surface area,

whereby liquid introduced into said zone flows with a controlled, predetermined peripheral configuration.

18. A device as defined in claim 17, wherein at least one of said surfaces is formed of a substantially liquid-impervious material.

19. A device as defined in claim 17, wherein said grooves of at least one of said surfaces are substantially straight and parallel through said zone, whereby a substantially linear wave front is formed between said surfaces as introduced liquid advances across said straight grooves.

20. A device as defined in claim 17, wherein said grooves of at least one of said surfaces are curvilinear and substantially parallel throughout said zone, whereby liquid introduced at said aperture produces a curvilinear wave front that advances curvilinearly.

21. A device as defined in claim 17, wherein said access means comprises an aperture located in at least one of said surfaces within said transport zone.

22. A device as defined in claim 17, wherein said surface areas have boundary portions which form an interior angle of greater than 180°

.

23. A method of transporting a liquid with a controlled peripheral configuration, comprising the steps of

introducing liquid between two fixedly mounted opposing surfaces substantially all portions of which are spaced apart throughout a zone of intended liquid transport a distance no greater than that effective to induce capillary flow in the liquid across said zone between said surfaces,

directing a portion of the introduced liquid to flow across one of said surfaces along a predetermined first pattern of paths,

and simultaneously directing another portion of the introduced liquid to flow across the other of said surfaces along a predetermined second pattern of paths, the paths of one surface forming positive angles with respect to the directly opposing paths of flow directed by the other surface.

24. A method as defined in claim 23, wherein said zone is defined by boundaries, and further including the step of directing a portion of the liquid to flow around a portion of said boundaries forming an interior angle of greater than 180°

.

25. A method as defined in claim 23, wherein said flow across at least one of said surfaces is directed to advance as a linear wave front.

26. A method as defined in claim 23, wherein said flow across at least one of said surfaces is directed to advance as a curvilinear wave front.

27. A method as defined in claim 23, wherein said liquid is a photographic developer solution.

28. In a method of analyzing a liquid, wherein a property of the liquid is detected after it is spread through a defined zone,

the improved process of spreading said liquid across the area, comprising:

(a) introducing the liquid between two fixedly mounted opposing surfaces which sandwich the zone, substantially all portions of said surfaces being spaced apart throughout said zone a distance no greater than that effective to induce capillary flow in the liquid,

(b) directing introduced liquid across one of said surfaces along first predetermined paths, and

(c) directing introduced liquid across the other of said surfaces along second predetermined paths which form positive angles with respect to said first paths.

29. In a method of analyzing a liquid, wherein a property of the liquid is detected after it is spread through a defined zone of intended liquid transport,

the process of transporting said liquid across the zone with a controlled peripheral configuration, comprising introducing the liquid between two surfaces having opposed surface areas substantially all portions of which are fixedly spaced throughout said zone a distance no greater than that effective to induce capillary flow and to define said transport zone, each of said surface areas having a plurality of grooves constructed in a predetermined pattern, at least a portion of the grooves of one surface area forming a positive angle with respect to the directly opposed grooves of the other surface area.

30. In a test element for analyzing a liquid at a test site, a liquid transport device for controlling liquid flow to said site, said device comprising

two fixedly mounted opposing surfaces substantially all portions of which are spaced apart throughout a zone of intended liquid transport a distance no greater than that distance effective to induce capillary flow of introduced liquid, and means to permit the introduction of liquid between said surfaces,

each of said surfaces including, across at least a portion thereof, means for directing capillary flow of introduced liquid along predetermined paths, said directing means on the respective surfaces being relatively oriented so that the paths directed by a substantial portion of one of said surfaces form positive angles with respect to the paths directed by the directly opposing portion of the other surface,

whereby capillary flow of liquid between said surfaces occurs in a controlled multidirectional manner with a predetermined peripheral configuration.

31. A test element for the analysis of a liquid comprising

two fixedly mounted opposing surfaces substantially all portions of which are spaced apart throughout a zone of intended liquid transport a distance no greater than that effective to induce capillary flow of introduced liquid, and means to permit the introduction of liquid between said surfaces,

each of said surfaces including, across at least a portion thereof, means for directing capillary flow of introduced liquid along predetermined paths, said directing means on the respective surfaces being relatively oriented so that the paths directed by a substantial portion of one of said surfaces form positive angles with respect to the paths directed by the directly opposing portion of the other surface,

whereby capillary flow of liquid between said surfaces occurs in a controlled multidirectional manner with a predetermined peripheral configuration,

and a reagent disposed on a portion of at least one of said surfaces for reaction with the liquid.

32. A liquid transport device for controlled fluid flow comprising

two fixedly mounted opposing surfaces substantially all portions of which are spaced apart throughout a zone of intended liquid transport a distance no greater than that effective to induce capillary flow of introduced liquid, and means to permit the introduction of liquid between said surfaces,

each of said surfaces including, across at least a portion thereof, a plurality of substantially parallel, spaced apart energy barriers to the capillary flow of liquid between said surfaces, at least a substantial portion of the barriers of one of said surfaces being disposed at positive angles with respect to the directly opposed barriers of the other surface to controllably induce the menisci of liquid introduced between said surfaces to advance with a predetermined, peripheral configuration.

33. A device as defined in claim 32, wherein said barriers comprise exposed grooves within said surfaces.