Oxygen measuring electrode assembly

• US 4,311,151 A
• Filed: 10/16/1979
• Issued: 01/19/1982
• Est. Priority Date: 08/24/1977
• Status: Expired due to Term

• Current Assignee: Bunji Hagihara
• Original Assignee: Bunji Hagihara
• Inventors: Hagihara, Bunji
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US06/085,397
• Time in Patent Office: 826 Days
• Field of Search: 128/635, 128/632, 204/195 B, 204/195 P
• US Class Current: 600/358
• CPC Class Codes: A61B 5/1491 Heated applicators
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: G01N 27/404 Cells with anode, cathode and cell electrolyte on the same side of a permeable membrane which separates them from the sample fluid , e.g. Clark-type oxygen sensors

Abstract

A polarographic electrode assembly for transcutaneous measurement of partial oxygen pressure in arterial blood comprising an anode, a cathode which has a thin ring surface or a circularly-bounded field of dot-shaped surfaces and an insulating electrode holder, a disposable tubular member holder fixedly holding the periphery of an oxygen permeable hydrophobic electrode membrane, and a skin-heating part including heat-conducting block which is thermally connected to a heater and a temperature detector. The heat-conducting block has a thick peripheral portion and thin disk-shaped inner portion having a through-hole to expose the cathode surface to the subject'"'"'s skin via the membrane. One side of the heat-conducting block has a smooth surface to be applied on skin, and the back side has a receiving space for the membrane holder. The heat-conducting block embraces the membrane holder which embraces the anode and cathode portion of the electrode part in such a manner that the membrane covers the working surfaces of the anode and cathode via an electrolyte layer. In a prefabrication step the membrane is strongly bonded in a uniformly stretched condition to the holder for stability of sensitivity of the electrode. By using such a cathode a good correlation coefficient of measured PO₂ over actual arterial PO₂ and a good S/N ratio are provided, and by using a skin heating block having a sufficient heating area a highly stable electrode sensitivity is assured.

Claims

1. A polarographic electrode assembly for transcutaneous measurement of partial oxygen pressure in arterial blood, comprising:

(a) an electrode part, including as an electrode unit;

an anode having a ring-shaped working surface;

cathode means constituting a cathode having working surface means constituting a working surface disposed within an imaginary circumscribing circle and perimetrically surrounded by said ring-shaped working surface of said anode, with radial spacing between said anode working surface and said cathode working surface means; and

an electrode holder of insulative material, said electrode holder holding said anode and said cathode means, maintaining said radial spacing, and providing an electrically and thermally insulated relationship for said anode and said cathode means relative to one another;

(b) a membrane holder part, including;

an oxygen-permeable hydrophobic electrode membrane having an outer peripheral margin; and

a cylindrical tubular membrane holder having an axially inner annular end face and an axially outer annular end face with a longitudinal bore extending between them;

means fixedly circumferentially holding said outer peripheral margin of said electrode membrane on said axially inner end face of said cylindrical tubular membrane holder with a predetermined, circumferentially substantially uniform tension and with said electrode membrane extending across said longitudinal bore; and

(c) a skin heating part, including;

an integral, heating conducting metal block having a radially inner relatively thin disk-shaped portion and a radially outer, relatively thick annular peripheral portion, each of these portions having an axially outer side and an axially inner side, the two axially inner sides being substantially axially aligned so as to provide one substantially flat surface incorporating both of them, but the axially outer side of said relatively thin disk-shaped portion lying substantially axially inwardly of said axially outer side of said relatively thick annular peripheral portion, so as to provide an electrolyte well having said axially outer side of said relatively thin disk-shaped portion as its bottom and a radially inwardly facing generally cylindrical surface of said relatively thick annular peripheral portion as its sidewall;

means providing a generally central hole axially through said relatively thin disk-shaped portion of said integral, heat conducting block, said through hole communicating with said well and being of a size and shape large enough to expose therethrough substantially all of said working surface means of said cathode means when said electrode unit is telescopically axially received in said well;

said substantially flat surface being adapted to be presented in confronting relation to the skin of a subject who is to be monitored, said substantially flat surface being larger in area than said through hole; and

an electric heater and a temperature-detecting element, both being mounted on said skin heating part so as to form a unitary subassembly therewith;

said electrode unit being axially telescopically removably received in the bore of said membrane holder part and both said electrode unit and said membrane holder part being axially telescopically removably received in said well of said skin heating part, with both said anode working surface and said cathode working surface means closely confronting said electrode membrane;

said electrode membrane extending across said through hole to provide a portion thereof axially exposed through said through hole and having said cathode working surface means in operable relationship therewith.

2. A polarographic electrode assembly in accordance with claim 1, wherein:

said working surface of said anode is a larger ring and said working surface means of said cathode means is a smaller ring disposed in a coaxial relation with said working surface of said anode.

3. A polarographic electrode assembly in accordance with claim 1 wherein:

said working surface means of said cathode means is constituted by a plurality of dot-shaped working surfaces uniformly disposed in a ring-shaped array which is in a coaxial relation with said working surface of said anode.

4. A polarographic electrode assembly in accordance with claim 1, wherein:

said working surface means of said cathode means is constituted by a plurality of dot-shaped working surfaces uniformly disposed within an imaginary circle which is in a coaxial relation with said working surface of said anode.

5. A polarographic electrode assembly in accordance with claim 1, wherein:

said working surface means of the cathode means protruding from a plane on which said periphery of said electrode membrane lies, thereby in assembled state said electrode membrane being set with a predetermined tension.

6. A polarographic electrode assembly in accordance with any one of claims 1, 2, 3, 4 and 5 wherein said working surface means of said cathode means is made of a noble metal selected from a group consisting of platinum and gold.

7. A polarographic electrode assembly in accordance with claim 1, wherein:

said skin heating part further includes a skin-contacting metal sheet which is thinner than said thin disk-shaped inner portion of said heat-conducting metal block but has an axial face which is larger in area than said circumscribing circle, said skin contacting metal sheet being heat-conductingly fixed on said substantially flat surface so as to perimetrically mask the radially outer margin of said portion of said electrode membrane that is exposed through said through hole of said disk shaped inner portion while exposing a limited region of said electrode membrane which is surrounded by said masked margin, and said working surface means of said cathode means being disposed on said limited region of said electrode membrane.

8. A polarographic electrode assembly in accordance with claim 7, wherein:

said working surface of said anode is a larger ring and said working surface means of said cathode means is a smaller ring and said working surface of said anode and said working surface means of said cathode means are disposed in a coaxial relation with each other.

9. A polarographic electrode assembly in accordance with claim 7, wherein:

said working surface means of said cathode means is constituted by a plurality of dot-shaped working surfaces uniformly disposed in a ring-shaped array which is in a coaxial relation with said working surface of said anode.

10. A polarographic electrode assembly in accordance with claim 7, wherein:

said working surface means of said cathode means is constituted by a plurality of dot-shaped working surfaces uniformly disposed within an imaginary circle which is in a coaxial relation with said working surface of said anode.

11. A polarographic electrode assembly in accordance with claim 7, wherein:

said working surface means of the cathode means protruding from a plane on which said periphery of said electrode membrane lies, thereby in assembled state said electrode membrane being set with a predetermined tension.

12. A polarographic electrode assembly in accordance with any one of claims 7 to 11 wherein working surface means of said cathode means is made of a noble metal selected from a group consisting of platinum and gold.