Anti-tumor quinazoline compounds
First Claim
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1. A compound having Formula I ##STR14## wherein one of R6 and R7 is oxiranylmethyl, and the other is methyl or oxiranylmethyl, and R2 and R4 are independently selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms, phenyl, substituted phenyl, phenylalkyl having up to 8 carbon atoms, substituted phenylalkyl having up to 8 carbon atoms apart from the substituents, wherein said substituted phenyl and substituted phenylalkyl have one or two ring attached groups independently selected from halogen, methyl, or methoxy groups.
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Abstract
4-Ethyl-6-methoxy-7-(oxiranylmethoxy)quinazoline and its isomer 4-ethyl-7-methoxy-6-(oxiranylmethoxy)quinazoline have potent anti-tumor activity in animals.
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3 Claims
- 1. A compound having Formula I ##STR14## wherein one of R6 and R7 is oxiranylmethyl, and the other is methyl or oxiranylmethyl, and R2 and R4 are independently selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms, phenyl, substituted phenyl, phenylalkyl having up to 8 carbon atoms, substituted phenylalkyl having up to 8 carbon atoms apart from the substituents, wherein said substituted phenyl and substituted phenylalkyl have one or two ring attached groups independently selected from halogen, methyl, or methoxy groups.
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Current AssigneeMead Johnson & Company (Reckitt Benckiser Group PLC)
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Original AssigneeMead Johnson & Company (Reckitt Benckiser Group PLC)
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InventorsComer, William T., Kreighbaum, William E.
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Primary Examiner(s)Daus, Donald G.
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Assistant Examiner(s)TURNIPSEED, JAMES
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Application NumberUS06/241,317Time in Patent Office522 DaysField of Search544/283US Class Current544/283CPC Class CodesA61P 35/00 Antineoplastic agentsC07D 239/74 with only hydrogen atoms, h...
