Flow metering apparatus for a fluid infusion system

• US 4,396,385 A
• Filed: 12/05/1980
• Issued: 08/02/1983
• Est. Priority Date: 12/05/1980
• Status: Expired due to Term

• Current Assignee: Baxter Travenol Laboratories Incorporated
• Original Assignee: Baxter Travenol Laboratories Incorporated
• Inventors: Kelly, Timothy G., Lohr, David A., St. John, Peter A.
• Primary Examiner(s): Truluck, Dalton L.
• Application Number:
  US06/213,353
• Time in Patent Office: 970 Days
• Field of Search: 128/214 E, 128/214 F, 128/214.2, 128/273, 128/DIG. 12, 417/22
• US Class Current: 604/152
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/16809 by repeated filling and emptying of an intermediate volume pressure infusion using positive displacement pumps A61M5/142
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

Metering apparatus for controlling the flow of fluid through a fluid infusion system at an operator-designated rate includes a single-use cassette having a syringe-type pump in the flow system. The cassette is removably mounted on actuator apparatus which drives the syringe plunger through alternate fill and pump modes to advance fluid through the system. To provide compensation for the lack of flow in the system during fill strokes, the plunger is advanced at a higher compensation rate for first and second portions of the pump stroke immediately preceding and immediately following each fill stroke, with the pump stroke advancing at the designated rate therebetween. This results in an average flow rate which corresponds to the designated rate. By making the first and second compensations of equal duration, the effect of the fill cycles on the regularity of the average flow rate is minimized.

Claims

1. Metering apparatus for use in conjunction with a fluid flow system for infusing fluids at an operator-selected rate into the human body, comprising:

metering means including valving means, and a syringe pump having a pump housing and a plunger, said plunger being arranged for reciprocative movement within said housing to provide alternate fill and pump strokes, for establishing in cooperation with said valving means fluid flow through the system;

actuator means for operatively engaging and reciprocatively driving said plunger to alternately provide fill strokes of relatively short duration, and pump strokes of relatively longer duration at the operator-selected flow rate, the average flow through the flow system as a result thereof being less than the operator-selected rate as a result of said intervening fill strokes; and

flow compensation means for increasing the rate of each of said pump strokes from the operator-selected rate to a relatively higher compensation rate for a first predetermined compensation period immediately following each preceding fill stroke, and for a second predetermined compensation period immediately preceding each succeeding fill stroke, the intervening portion of each pump stroke being at the operator-selected rate, said compensation periods each comprising a substantial portion of a total compensation period during the pump stroke which compensates for the non-occurrence of pumping action during a fill stroke, whereby the resulting average flow rate through the flow system comprises the operator-selected rate.

2. Metering apparatus as defined in claim 1 wherein said first and second predetermined compensation periods are substantially equal.

3. Metering apparatus as defined in claim 1 wherein said syringe pump is contained within a disposable cassette, the actuator means include actuator station, and said cassette is removably received by said actuator station.

4. Metering apparatus as defined in claim 3 wherein said actuator station includes a reciprocatively driven projecting actuator member, and said plunger is detachably coupled to said member.

5. Metering apparatus as defined in claim 1 wherein said valving means of the flow system comprises a flow control valve, and said actuator means include valve control means for positioning said valve in a first position during said fill stroke, and in a second position during said pump stroke.

6. Metering apparatus as defined in claim 1 wherein said compensation rate is approximately four times the uncompensated pump stroke rate.

7. Metering apparatus as defined in claim 1 wherein said first and second predetermined compensation periods vary as a percentage of the pump stroke according to the operator-selected flow rate.

8. Metering apparatus as defined in claim 1 wherein said actuator means comprise a stepper motor responsive to applied stepping pulses for driving said syringe, and wherein said actuator means provide stepping pulses to said motor to drive said plunger in said fill and pump strokes.

9. Metering apparatus as defined in claim 8 wherein said flow compensation means include first register means for counting the stepping pulses applied to said motor during said pump stroke, said compensation periods being initiated following the counting of predetermined numbers of said applied stepping pulses.

10. Metering apparatus as defined in claim 9 wherein said flow compensation means include second register means for determining the duration of said compensation periods, said second register means being responsive to the counting of a predetermined number of said applied stepping pulses for terminating said compensation periods.

11. Metering apparatus as defined in claim 10 including computation means responsive to the operator selected rate for establishing said first and second predetermined numbers of stepping pulses required by said first and second register means.

12. Metering apparatus as defined in claim 11 wherein said computation means comprise a microprocessor.

16. Metering apparatus as defined in claim 7 wherein said first and second compensation periods are substantially equal.

13. The method of infusing fluids through an infusion system at a designated operator-selected rate by means of a syringe-type pump in the system into the human body, comprising the steps of:

driving the plunger of the syringe-type pump in alternate fill and pump strokes, and valving the flow system to direct the consequent repetitive filling and emptying of the syringe pump chamber to cause fluid flow through the system, the nominal speed of each pump stroke being at a rate corresponding to the operator designated flow rate; and

compensating the flow rate in the system for intervening fill strokes by increasing the speed of the plunger for a first portion of each pump stroke immediately preceding each fill stroke, and for a second portion of each pump stroke immediately following each fill stroke, while maintaining the speed of the plunger at the operator-selected rate in the intervening portion of each pump stroke, the first and second compensating portions each comprising a substantial portion of a total compensation period during the pump stroke which compensates for the non-occurrence of pumping action during a fill stroke, whereby the average flow rate through the system substantially corresponds to the operator designated rate.

14. The method of infusing fluids as defined in claim 13 wherein the first and second compensating portions of each pump stroke are substantially equal.

15. Metering apparatus for use in conjunction with a fluid flow system for infusing fluids at an operator-selected rate into the human body, comprising:

metering means including valving means, and a syringe-type pump in the flow system having a pump housing and a plunger mounted for reciprocative movement within the housing to provide in cooperation with the valve means alternate fill and pump strokes for establishing fluid flow through the system;

actuator means including a motor responsive to applied stepping pulses for operatively engaging and reciprocatively driving said plunger;

motor drive means for providing stepping pulses to said motor, said stepping pulses occurring at a first relatively high predetermined frequency to advance the plunger at a relatively rapid rate during each fill stroke, and at a second relatively low predetermined frequency to advance the plunger at the operator-selected flow rate during each pump stroke, the average flow through the flow system as a result thereof being less than the operator-selected rate as a result of the intervening fill strokes; and

flow compensation means for increasing the frequency of said stepping pulses from said second predetermined frequency to a higher compensating frequency for a first predetermined compensation period immediately following each preceding fill stroke, and for a second predetermined compensation period immediately preceding each succeeding fill stroke, the intervening portion of each pump stroke being at said operator-selected rate, said compensation periods each comprising a substantial portion of a total compensation period during the pump stroke which compensates for the nonoccurrence of pumping action during a fill stroke, whereby the resulting average flow rate through the infusion system comprises the operator-selected rate.

17. Metering apparatus as defined in claim 15 wherein said compensation means include first register means for counting the stepping pulses applied to said motor during each pump stroke, said compensation periods being initiated following the counting of a predetermined numbers of said applied stepping pulses.

18. Metering apparatus as defined in claim 17 wherein said flow compensation means include second register means for determining the duration of said compensation periods, said second register means being responsive to the counting of a predetermined number of said applied stepping pulses for terminating said compensation periods.

19. Metering apparatus as defined in claim 18 including computation means responsive to the operator designated rate for establishing said first and second predetermined numbers of counted stepping pulses required by said first and second register means.

20. Metering apparatus for use in conjunction with a disposable single-use fluid flow system of the type having valving means, and a syringe-type cassette pump having a pump housing and a plunger mounted for reciprocative movement within the pump housing to provide alternate fill and pump strokes for establishing in cooperation with the valving means fluid flow through the system for infusing fluids at an operator-selected rate into the human body, comprising:

actuator station means for receiving and fixedly positioning the cassette pump;

actuator means for operatively engaging and reciprocatively driving the plunger while positioned in said actuator station to provide fill strokes of relatively short duration, and pump strokes of relatively longer duration at the operator-selected flow rate, the average flow through the flow system as a result of the intervening fill strokes being less than the operator-selected rate; and

flow compensation means for increasing the rate of each of said pump strokes from the operator-selected rate to a relatively higher compensation rate for a first predetermined compensation period immediately following each preceding fill stroke, and for a second predetermined compensation period immediately preceding each succeeding fill stroke, the intervening portion of each pump stroke being at the operator-selected rate, said compensation periods each comprising a substantial portion of a total compensation period during the pump strokes which compensates for the non-occurrence of pumping action during a fill stroke, whereby the resulting average flow rate through the flow system comprises the operator-selected rate.

21. Metering apparatus as defined in claim 20 wherein said first and second compensation periods are substantially equal.

22. Metering apparatus as defined in claim 20 wherein said actuator means include a reciprocatively driven actuator member projecting from said housing, and the plunger is detachably coupled to said actuator member.

23. Metering apparatus as defined in claim 20 wherein the valving means of the flow system comprise a flow control valve, and said actuator means include valve control means for positioning the valve in a first position during the fill stroke, and in a second position during the pump stroke.

24. Metering apparatus as defined in claim 20 wherein said actuator means comprise a stepper motor responsive to applied stepping pulses for driving said syringe, and wherein said actuator means provide stepping pulses to said motor to drive said plunger in said fill and pump strokes.

25. Metering apparatus as defined in claim 24 wherein said flow compensation means include first register means for counting the stepping pulses applied to said motor during said pump stroke, said compensation periods being initiated following the counting of predetermined numbers of said applied stepping pulses.

26. Metering apparatus as defined in claim 25 wherein said flow compensation means include second register means for determining the duration of said compensation periods, said second register means being responsive to the counting of a predetermined number of said applied stepping pulses for terminating said compensation periods.

27. Metering apparatus as defined in claim 26 including computation means responsive to the operator selected rate for establishing said first and second predetermined numbers of stepping pulses required by said first and second register means.

28. Metering apparatus as defined in claim 27 wherein said computation means comprise a microprocessor.

29. Metering apparatus as defined in claim 20 wherein said compensation rate is approximately four times the uncompensated pump stroke rate.

30. Metering apparatus for use in conjunction with a disposable single-use fluid flow system of the type including valving means, and a syringe-type cassette pump having a pump housing and a plunger mounted for reciprocative movement within the pump housing to provide alternate fill and pump strokes for establishing in cooperation with the valving means fluid flow through the system for infusing fluids at an operator-selected rate into the human body, comprising:

actuator station means for receiving and fixedly positioning the cassette pump;

actuator means including a motor responsive to applied stepping pulses for operatively engaging and reciprocatively driving the plunger while positioned in said actuator station;

motor drive means for providing stepping pulses to said motor, said stepping pulses occurring at a first relatively high predetermined frequency to advance the plunger at a relatively rapid rate during each fill stroke, and at a second relatively low predetermined frequency to advance the plunger at the operator-selected flow rate during each pump stroke, the average flow through the flow system as a result thereof being less than the operator-selected rate as a result of the intervening fill strokes; and

flow compensation means for increasing the frequency of said stepping pulses from said second predetermined frequency to a higher compensating frequency for a first predetermined compensation period immediately following each preceding fill stroke, and for a second predetermined compensation period immediately preceding each succeeding fill stroke, the intervening portion of each pump stroke being at said operator-selected rate, said compensation periods each comprising a substantial portion of a total compensation period during the pump stroke which compensates for the nonoccurrence of pumping action during a fill stroke, whereby the resulting average flow rate through the infusion system comprises the operator-selected rate.

31. Metering apparatus as defined in claim 30 wherein said first and second compensation periods are substantially equal.

32. Metering apparatus as defined in claim 31 wherein said compensation means include first register means for counting the stepping pulses applied to said motor during each pump stroke, said compensation periods being initiated following the counting of predetermined numbers of said applied stepping pulses.

33. Metering apparatus as defined in claim 32 wherein said flow compensation means include second register means for determining the duration of said compensation periods, said second register means being responsive to the counting of a predetermined number of said applied stepping pulses for terminating said compensation periods.

34. Metering apparatus as defined in claim 33 including computation means responsive to the operator designated rate for establishing said first and second predetermined numbers of counter stepping pulses required by said first and second register means.