Composition of matter and process
First Claim
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1. A process for preparing a compound of the formulawherein R2 and R3 are hydrogen, alkyl of from 1 to 5 carbon atoms, inclusive, and phenyl;
- R4 is selected from the group consisting of SO2 R2, SO2 CH2 COphenyl, CO2 CH2 Z where Z is selected from the group consisting of CH2 I, CCl3, CH2 SO2 R2, phenyl, and fluorenylmethyl, which comprises reacting a compound of the formula ##STR3## wherein R2, R3, and R4, are as defined above, and X is selected from the group consisting of OSO2 R2, Cl, Br, and I, with triphenylphosphine/carbon tetrahalide, concentrating the reaction mixture in vacuo to a concentrate and applying said concentrate to a thick-layer silica gel plate to give the desired compound.
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Abstract
Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[ c]-benzo[1,2-b:-4,3-b'"'"']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
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1 Claim
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1. A process for preparing a compound of the formula
wherein R2 and R3 are hydrogen, alkyl of from 1 to 5 carbon atoms, inclusive, and phenyl; - R4 is selected from the group consisting of SO2 R2, SO2 CH2 COphenyl, CO2 CH2 Z where Z is selected from the group consisting of CH2 I, CCl3, CH2 SO2 R2, phenyl, and fluorenylmethyl, which comprises reacting a compound of the formula ##STR3## wherein R2, R3, and R4, are as defined above, and X is selected from the group consisting of OSO2 R2, Cl, Br, and I, with triphenylphosphine/carbon tetrahalide, concentrating the reaction mixture in vacuo to a concentrate and applying said concentrate to a thick-layer silica gel plate to give the desired compound.
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