Method for providing an oxygen bearing liquid to a blood vessel for the performance of a medical procedure

• US 4,448,188 A
• Filed: 02/18/1982
• Issued: 05/15/1984
• Est. Priority Date: 02/18/1982
• Status: Expired due to Fees

• Current Assignee: Laserscope (Endo International PLC)
• Original Assignee: Laserscope (Endo International PLC)
• Inventors: Loeb, Marvin P.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Fukushima, Christine A.
• Application Number:
  US06/349,718
• Time in Patent Office: 817 Days
• Field of Search: 128/1 R, 128/6, 128/303.1, 128/303.11, 128/303.12, 128/325, 128/344, 128/346, 128/395, 604/96
• US Class Current: 600/108
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 18/245 for removing obstructions in blood vessels or calculi
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61M 2202/0476 Oxygenated solutions

Abstract

A method for providing an oxygen bearing liquid to a blood vessel during the performance of a medical procedure is disclosed. In one preferred embodiment the blood flow is temporarily occluded, a substantially clear oxygen bearing liquid is introduced into the blood vessel and the inside of the blood vessel is inspected through a viewing system and treated with laser irradiation.

Claims

1. A method for obtaining access to a site in a blood vessel for the performance of a medical procedure, the method comprising the steps of:

(a) temporarily occluding the blood vessel by introducing therein, upstream of the site, removable flow occluding means;

(b) introducing downstream of the flow occluding means a physiologically compatible liquid, from an external source, bearing sufficient available oxygen to maintain the viability of tissue downstream of the flow obstruction means while the blood vessel is occluded; and

(c) positioning operative means adjacent the site for performing the medical procedure.

2. The method of claim 1 wherein the oxygen bearing liquid is substantially clear.

3. The method of claim 1 wherein oxygen bearing liquid is a water based emulsion of a perfluorocarbon.

4. The method of claim 1 wherein the oxygen bearing liquid includes blood.

5. The method of claim 1 wherein the operative means includes a laser light transmitting fiber and the method includes introducing a substantially clear flushing fluid into the blood vessel during at least part of the performance of the medical procedure.

6. The method of claim 1 wherein a substantially clear flushing fluid is introduced into the blood vessel downstream of the flow occluding means during at least part of the performance of the medical procedure.

7. The method of claim 6 wherein the flushing fluid is saline.

8. The method of claim 6 wherein the flushing fluid is carbon dioxide.

9. The method of claim 6 wherein the flushing fluid includes blood.

10. The method of claim 6 wherein the flushing fluid is a substantially clear water based emulsion of a perflurocarbon.

11. The method of claim 6 wherein a flushing fluid is introduced intermittently.

12. The method of claim 1 wherein said medical procedure is the removal of a deposit at the site and the operative means includes a laser light transmitting fiber for directing laser irradiation at the site to remove at least a portion of the deposit.

13. The method of claim 1 wherein the operative means includes a viewing system and the method includes introducing a substantially clear flushing fluid into the blood vessel during at least part of the performance of the medical procedure.

14. The method of claim 13 wherein the flushing fluid is a substantially clear, physiologically compatible liquid bearing available oxygen.

15. The method of claim 13 wherein the medical procedure is the removal of a deposit at the site and the operative means includes a laser light transmitting fiber for directing laser irradiation at the site for a time period sufficient to remove at least a portion of the deposit.

16. The method of claim 1 wherein the medical procedure is removing tissue from the blood vessel site and the operative means includes tissue collecting means.

17. The method of claim 16 wherein the tissue collecting means includes a tube and wherein the medical procedure includes placing the end of the tube in contact with the tissue, introducing a negative pressure within the tube to grasp the tissue, and retracting the tube from the site to remove the tissue from the blood vessel.

18. The method of claim 1 wherein the oxygen bearing liquid is a water-based emulsion of a perfluorocarbon having an average particle size below about 0.2 micrometer.

19. The method of claim 1 wherein a plurality of oxygen bearing liquids is introduced in sequence.

20. A method of treating a site in a blood vessel with laser irradiation, the method comprising the steps of:

(a) positioning within the blood vessel, proximate the site, the distal end of a conduit carrying a viewing system and means for emitting laser irradiation from the distal end of the conduit;

(b) temporarily occluding the blood vessel upstream of the of the site;

(c) introducing downstream of the produced occlusion and about the site a physiologically compatible liquid, from an external source, bearing sufficient available oxygen to maintain the viability of tissue downstream of the occlusion while the blood vessel is occluded;

(d) positioning the distal end of the conduit adjacent the site such that the site can be viewed through the viewing system when the physiologically compatible oxygen bearing fluid is substantially clear; and

(e) transmitting laser light through the conduit to subject the site with laser irradiation when the physiologically compatible oxygen bearing is sufficiently transparent to laser energy.

21. The method of claim 20 wherein the oxygen bearing liquid is introduced as a stream from a fluid passageway upstream of the site.

22. The method of claim 20 wherein the oxygen bearing liquid includes blood.

23. The method of claim 20 wherein the oxygen bearing liquid is a water based emulsion of a perfluorocarbon.

24. The method of claim 23 wherein the emulsion has an average particle size below about 0.2 micrometers.

25. The method of claim 20 wherein a substantially clear flushing fluid is introduced into the blood vessel downstream of the fluid occluding means for at least a portion of the performance of the medical procedure.

26. The method of claim 25 wherein the flushing fluid is saline.

27. The method of claim 25 wherein the flushing fluid is carbon dioxide.

28. The method of claim 25 wherein the flushing fluid includes blood.

29. The method of claim 25 wherein a flushing fluid is introduced intermittently.

30. The method of claim 20 wherein a plurality of oxygen bearing fluids is introduced in sequence.