4-Naphthyl and substituted naphthyl-3-hydroxy-3-pyrroline-2,5-diones and their use as inhibitors of glycolic acid oxidase
First Claim
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1. The compounds having the structural formula:
- ##STR28## wherein R4 is hydrogen, halogen, loweralkyl having 1 to 6 carbon atoms or ##STR29## or a pharmaceutically acceptable salt thereof.
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Abstract
Novel 4-substituted-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate kidney stone formation. A novel process for their preparation is also disclosed.
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3 Claims
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1. The compounds having the structural formula:
- ##STR28## wherein R4 is hydrogen, halogen, loweralkyl having 1 to 6 carbon atoms or ##STR29## or a pharmaceutically acceptable salt thereof.
- View Dependent Claims (2)
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3. A method of treating or preventing the formation of calcium oxalate kidney or bladder stones which comprises administering to a patient with or prone to renal lithiasis an effective amount of a compound having the structural formula:
- ##STR30## wherein R4 is hydrogen, halogen, loweralkyl having 1 to 6 carbon atoms or ##STR31## or a pharmaceutically acceptable salt thereof.
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