Blood glucose control apparatus and method

• US 4,464,170 A
• Filed: 09/29/1982
• Issued: 08/07/1984
• Est. Priority Date: 09/29/1982
• Status: Expired due to Term

• Current Assignee: Miles Laboratories, Inc. (Bayer AG)
• Original Assignee: Miles Laboratories, Inc. (Bayer AG)
• Inventors: Hough, David L., Clemens, A. H.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Jaworski, Francis J.
• Application Number:
  US06/428,381
• Time in Patent Office: 678 Days
• Field of Search: 604/2, 604/4, 604/50, 604/66-67, 128/632-633, 128/DIG. 13
• US Class Current: 604/504
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: Y10S 128/13 Infusion monitoring

Abstract

In a method and apparatus for controlling the concentration of glucose in the blood stream of a subject at a desired level (BI) including controlling the supply of insulin (IR) by periodically measuring the blood glucose concentration (G) and selecting a predetermined basal infusion rate (RI) for the desired level, the step of selecting a predetermined basal infusion rate comprises periodically searching for the value of the basal infusion rate RI required for BI in accordance with

RI=RI.sub.LAST (GY/BI)

where (GY) is the present blood glucose level corrected to fit a least squares regression line, when the slope of the least squares regression line fit for the last five G values is less than 0.5 and GY is within ±50% of the desired BI level, and wherein the period between searches is equal to or greater than the period between glucose measurements.

Claims

1. In an apparatus for controlling the concentration of glucose in the blood stream of a subject at a desired level (BI) having means for controlling the infusion rate of insulin as a function of the periodically measured blood glucose concentration (G) and a predetermined basal infusion rate (RI) for the desired level, the improvement comprising means for periodically searching for and determining the basal infusion rate RI for the desired level in accordance with:

space="preserve" listing-type="equation">RI=RI.sub.LAST (GY/BI)

said means for searching and determining including means for determining the present blood glucose concentration value (GY), means for fitting a plurality of blood glucose concentrations (G) to a least squares regression line and for determining if the slope of the least squares regression line fit for the least five G values is less than 0.5 and if GY is within ±

50% of the desired BI level, said means for searching and determining conducting searches at periods equal to or greater than the period between glucose measurements.

2. The apparatus according to claim 1, wherein the means for controlling the supply of insulin as a function of the periodically measured blood glucose concentration measures same minute-to-minute and the means for periodically searching for the basal infusion rate examines the basal infusion rate every 10 minutes.

3. In a method for controlling the concentration of glucose in the blood stream of a subject at a desired level (BI) including controlling the supply of insulin by periodically measuring the blood glucose concentration (G) and selecting a predetermined basal infusion rate (RI) for the desired level, the improvement wherein the step of selecting a predetermined basal infusion rate comprises periodically searching for and determining the value of the predetermined basal infusion rate RI required for BI in accordance with

View Dependent Claims (4)

4. The method according to claim 3, wherein the glucose concentration is measured minute-to-minute and the periodic measuring is effected every 10 minutes.