Apparatus for improving blood sugar control in diabetics

• US 4,475,901 A
• Filed: 11/06/1981
• Issued: 10/09/1984
• Est. Priority Date: 07/23/1980
• Status: Expired due to Fees

• Current Assignee: Commonwealth Scientific & Industrial Research Organisation (Commonwealth Of Australia As Represented By Department Of Industry, Innovation, Climate Change, Science, Research And Tertiary Education), Garvan Research Development Limited The New South Wales
• Original Assignee: Commonwealth of Australia, The Garvan Research Development Limited
• Inventors: Kraegen, Edward W., Lazarus, Leslie, Bell, David J., Chisholm, Donald J.
• Primary Examiner(s): Coven, Edward M.
• Application Number:
  US06/318,775
• Time in Patent Office: 1,068 Days
• Field of Search: 128/213 R, 128/214 R, 128/214 E, 128/214 F, 128/260, 128/419 P, 604/65, 604/66, 604/67
• US Class Current: 604/67
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

There is provided an apparatus to improve control of blood sugars in diabetics. The apparatus comprises an infusion means and a control means which controls the infusion rate of one or more diabetics control liquids. The control means comprises a basal rate means to control infusion of the liquid according to an assessed basal metabolic requirement and a non-basal rate means to control infusion of the liquid at one or more levels of metabolic activity. The control means is preferably adapted to receive patient data to vary the infusion of the liquid accordingly.

Claims

1. A hybrid open loop/closed loop infusion system comprising an infusion means and a control means connected thereto to control the operation of said infusion means, wherein said infusion means comprises a first pump connected between a first diabetic control liquid reservoir and a tissue access system adapted to be connected to the body of a patient whereby a first diabetic control liquid from said reservoir is infused into said body via said access system;

and a second pump connected between a second diabetic control liquid reservoir and said access system whereby a second diabetic control liquid from said second reservoir is infused into said body via said access system; and

wherein said control means comprises a basal rate means, a meal rate means, a hyperglycaemic rate means, a hypoglycaemic rate means, a patient blood data entry means and a patient factor entry means;

said basal rate means operating said first pump in an open loop mode at a base rate corresponding to an anticipated assessed basal metabolic requirement of said patient, said meal rate means increasing the open loop mode operation of said first pump by predetermined amounts over a predetermined time corresponding to anticipated ingestion of food by, or physical activity of, said patient, said patient blood data entry means being adapted to receive and store patient blood data derived from at least one of a plurality of successive patient blood samplings each taken after an interval of the order of one hour since the previous patient blood sampling and operating said first pump in a quasi-closed loop feedback mode at a first rate dependent upon said blood data but between a predetermined maximum first rate and a predetermined minimum first rate, said patient being able to be infused with safety at said first rate during said interval between successive samplings, said hyperglycaemic rate means operating said first pump at a predetermined hyperglycaemic rate in excess of said predetermined maximum first rate and operating said second pump at a zero or low rate, said hypoglycaemic rate means operating said first pump at a zero rate or a low rate less than said predetermined minimum first rate and operating said second pump at a hypoglycaemic rate, and said patient factor entry means being associated with said data entry means and adapted to receive and store a patient factor which varies from individual patient to individual patient;

said predetermined maximum first rate and said predetermined minimum first rate controlled by said data entry means being adjusted by said patient factor entry means in accordance with said patient factor.

2. The system as claimed in claim 1 wherein the rate of operation of said first pump depending upon said blood data is adjusted in accordance with said patient factor.

3. The system as claimed in claim 1 or 2 wherein said patient factor is a numerical constant which multiplies the first pump rates.

4. The system as claimed in claim 1 or 2 wherein said basal rate and said predetermined amounts are adjusted in accordance with said patient factor.

5. The system as claimed in claim 4 wherein said patient factor is a numerical constant which multiplies said basal rate and said predetermined amounts.

6. The system as claimed in claim 1 or 2 wherein said first diabetic control liquid contains insulin.

7. The system as claimed in claim 6 wherein said second diabetic control liquid contains dextrose.

8. The system as claimed in claim 1 or 2 further including means by which intravenous nutrition can be infused to said patient in the form of an infusible solution.

9. The system as claimed in claim 1 or 2 wherein said control means further includes means to sound an alarm when an entry of patient blood data is not received by said patient blood data entry means upon the expiry of said interval.

10. The system as claimed in claim 9 wherein in the absence of an entry of patient blood data into said patient blood data entry means upon the expiration of said interval, the rate of operation of said first pump reverts to said base rate.