Device for automatically and continuously measuring the constituent parts of blood

• US 4,512,348 A
• Filed: 04/23/1982
• Issued: 04/23/1985
• Est. Priority Date: 04/24/1981
• Status: Expired due to Term

• Current Assignee: Kabushiki Kaisha Kyoto Daiichi Kagaku
• Original Assignee: Kabushiki Kaisha Kyoto Daiichi Kagaku
• Inventors: Yamada, Naoki, Uchigaki, Takatoshi, Saito, Akio
• Primary Examiner(s): Coven, Edward M.
• Application Number:
  US06/371,482
• Time in Patent Office: 1,096 Days
• Field of Search: 128/630, 128/632, 128/637, 128/760, 436/95, 422/64, 422/67, 422/81, 73/1 R
• US Class Current: 600/364
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150229 Pumps for assisting the blood sampling
• CPC Class Codes: A61B 5/150992 Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings, valves tubing connectors and couplings A61M39/00
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61M 1/3672 Means preventing coagulation
• CPC Class Codes: A61M 1/3673 Anticoagulant coating, e.g. Heparin coating
• CPC Class Codes: G01N 33/48 Biological material, e.g. blood, urine G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence; Haemocytometers counting blood corpuscules distributed over a surface by scanning the surface G06M11/02

Abstract

At the time of drawing the blood continuously from the vein of the patient by means of a catheter and measuring the concentration of a specified constituent part contained in the blood automatically and continuously for long hours, the sample liquid and two sorts of correcting liquids (standard liquid I and base liquid) are sucked by a single sampling nozzle in prescribed order and are supplied to the measuring section through a common channel. Each of the liquids are diluted with a buffer solution at the identical rate with the manifold in the measuring section, are separated from one another through the interposition of air layers among them, and supplied to a sensor. The outputs of the measured sample liquid from the sensor are corrected by the outputs of each of the neighboring measured correcting liquids in succession and are displayed as measured values. In the blood-drawing section, there is used a double-current catheter having the first and second catheter arrangements which are constructed so as to be incorporated directly into the tube pump.

Claims

1. A device for automatically and continously measuring constituent parts of blood, said constituent parts being continuously drawn from the blood by means of a catheter inserted in a vein, comprising:

blood drawing means for drawing blood;

a tube pump coupled to said blood drawing means;

sample liquid cup means for holding a sample liquid received from said blood drawing means by said tube drawing pump;

standard liquid cup means for holding a standard liquid;

base liquid cup for receiving a base liquid;

sensor means for sensing said constituent part;

sensor means correction means responsive to said standard liquid and said base liquid for correcting said sensor means;

sampling means comprising a single sampling nozzle and nozzle tube for withdrawing said sample liquid, standard and base liquid from their respective cups in a predetermined order, said sampling means further comprising means for separating said withdrawn sample, standard and base liquids with air;

manifold means for receiving said separated standard liquid, base liquid and sample liquid, and for diluting them at an equal rate by the use of a buffer solution, and for interposing a layer of air between said diluted sample, base and standard liquid, and for providing the diluted and separated sample, standard and base liquid as respective measuring liquids; and

operation control means coupled to said sensor means for receiving successive signals, in order therefrom, and for correcting said sensor output signals of said sample liquid according to said standard liquid and said base liquid, and for further displaying the value of said constituent part, and further for controlling the operation of said sampling device.

2. A device for automatically and continuously measuring the constituent parts of the blood as set forth in claim 1, wherein said sampling device further comprises a nozzle-holding arm having a front end part supporting said nozzle vertically at said front end part, said nozzle tube connects said nozzle to a tube pump means for sampling use, and a nozzle-holding arm driving mechanism making a front end part of said nozzle-holding arm move back and forth tracing a circular arc, wherein said base liquid cup is fixed fast under either the front end part or a rear end part of said nozzle-holding arm, while said sample liquid cup and said standard liquid cup take positions by turns under another end part of said arm opposingly to said base liquid cup.

3. A device for automatically and continuously measuring the constituent part of the blood as set forth in claim 1 or 2, wherein said catheter is a double-current catheter having a first catheter means for introducing an anticoagulant into a canula and a second catheter means for sucking and taking-out a mixed liquid of the blood and said anticoagulant out of said canula.

4. A device for automatically and continuously measuring the constituent part of the blood as set forth in claim 3, further comprising an anticoagulant container for containing said anticoagulant wherein said first catheter means is formed of a single and continous tube coupled at an end to sad anticoagulant container and said second catheter means is made of a single and continuous tube connected at an end part to said sample liquid cup, wherein said tube pump comprises first and second tube pumps said first catheter means and said second catheter means are coupled to a first tube pump and a second tube pump, respectively, whereby the conveyance of liquids is effectuated by said first tube pump or said second tube pump, respectively.

5. A device for automatically and continuously measuring the constituent part of the blood as set forth in claim 4, further including a bottle needle wherein said first catheter means is coupled at its end part to said bottle needle, while said second catheter means is coupled at its end part to a connecting pipe.

6. The product according to claim 5 wherein said first and second catheter means have substantially identical interior diameters.