Continuous blood gas monitoring

• US 4,516,580 A
• Filed: 12/29/1981
• Issued: 05/14/1985
• Est. Priority Date: 12/28/1981
• Status: Expired due to Fees

• Current Assignee: Michael L. Polanyi
• Original Assignee: Michael L. Polanyi
• Inventors: Polanyi, Michael L.
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US06/335,391
• Time in Patent Office: 1,232 Days
• Field of Search: 128/632, 604/43, 604/93, 604/103, 210/321.1, 210/321.2, 210/321.3, 210/321.4, 73/19, 73/863.23, 55/158, 55/159, 422/83, 422/101, 436/68
• US Class Current: 600/364
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: G01N 27/40 Semi-permeable membranes or partitions
• CPC Class Codes: G01N 33/4925 measuring blood gas content, e.g. O2, CO2 , HCO3

Abstract

A method and apparatus for measuring of concentrations of components of a fluid mixture. One side of a membrane permeable to the component to be determined is contacted with a sample of the fluid mixture to be analyzed. The second side of the membrane is contacted with a test fluid passing the membrane at different speeds. The resultant properties of the test fluid are determined for the different speeds of flow past the membrane and the measured values allow to determine the concentration or partial pressure of the component in the fluid mixture. The fluid mixture is preferably blood and the components can be oxygen and carbon dioxide. Preferably the membrane provides a spiral path for the test fluid in order to allow employing a more rapid flow of the test fluid past the membrane. Furthermore, such a configuration can be combined with a catheter for hemodynamic blood pressure measurement thereby providing a single probe for continuous monitoring of blood in clinical practice.

Claims

1. A method for measuring the concentration of components of a fluid mixture comprising

contacting one side of a membrane permeable to the component to be determined with a sample of the fluid mixture to be analyzed;

contacting the second side of the membrane with a test fluid for the component to be determined with the test fluid contacting the membrane according to a first setting of a relevant parameter;

contacting successively the second side of the membrane with the test fluid for the component to be determined with the test fluid contacting the membrane according to a second setting of a relevant parameter;

analyzing the resultant properties of the test fluid having contacted the membrane according to the first setting of a relevant parameter;

analyzing the resultant properties of the test fluid having contacted the membrane according to the second setting of a relevant parameter, for establishing the concentration of the component to be determined from the resulting analytical values of the test fluid obtained from both analyzing the resultant properties of the test fluid having contacted the membrane according to both settings of a relevant parameter.

2. The method according to claim 1 wherein the fluid mixture is blood.

3. The method according to claim 1 wherein the fluids are liquids.

4. The method according to claim 1 wherein the component to be determined of the fluid mixture forms a gas at room temperature.

5. The method according to claim 1 wherein the component to be determined is a member of the group consisting of oxygen, carbon dioxide and mixtures thereof.

6. The method according to claim 1 wherein the test fluid contacting the membrane according to a first setting of a relevant parameter is passing the membrane at a first speed and

wherein the test fluid contacting the membrane according to a second setting of a relevant parameter is passing the membrane at a second speed.

7. The method according to claim 6 further comprising

analyzing the test fluid after having passed the membrane at a first speed for the concentration of the component to be determined;

analyzing the test fluid after having passed the membrane at a second speed for the concentration of the component to be determined; and

processing the resulting analytical data automatically.

8. The method according to claim 6

wherein the concentration of the component is obtained substantially by applying the formula ##EQU8## where Q₁ is the speed of the test fluid passing the membrane at a first speed:

Q₂ is the speed of the test fluid passing the membrane at a second speed;

P_b is the partial pressure of the component to be determined in the fluid mixture;

P_o is the partial pressure of the component to be determined in the incoming test fluid;

P₁ is the partial pressure of the component to be determined in the test fluid after having passed the membrane at a first speed; and

P₂ is the partial pressure of the component to be determined in the test fluid after having passed the membrane at a second speed.

9. The method according to claim 6 wherein the partial pressure P_o of the component to be determined in the incoming test fluid is substantially equal to zero.

10. The method according to claim 6 further comprising

passing the test fluid through a substantially helical membrane coil having on its outside the fluid mixture.

11. The method according to claim 1

wherein the test fluid contacting the membrane according to a first setting of a relevant parameter is left in contact with the membrane for the duration of a first time interval T₁ ;

and

where the test fluid contacting the membrane according to a second setting of a relevant parameter is left in contact with the membrane for the duration of a second time interval T₂.

12. The method according to claim 11 further comprising

analyzing the test fluid having contacted the membrane for a first time interval T₁ for the component to be determined;

analyzing the test fluid having contacted the membrane for a second time interval T₂ for the component to be determined; and

processing the resulting analytical data to obtain the partial pressure P_b of the component in the fluid mixture substantially according to the formula ##EQU9## where P_o is the partial pressure in the incoming test fluid of the component to be determined;

P₁ is the partial pressure of the component to be determined in the test fluid after having been in contact with the membrane for the duration of a first time interval T₁ ; and

P₂ is the partial pressure of the component to be determined in the test fluid after having been in contact with the membrane for the duration of a second time interval T₂.