Electroencephalographic system for intra-operative open-heart surgery

• US 4,557,270 A
• Filed: 08/23/1983
• Issued: 12/10/1985
• Est. Priority Date: 08/23/1983
• Status: Expired due to Fees

• Current Assignee: New York University
• Original Assignee: New York University
• Inventors: John, Erwin R.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Sykes, Angela D.
• Application Number:
  US06/525,628
• Time in Patent Office: 840 Days
• Field of Search: 128/731-733, 128/691, 128/694, 128/736
• US Class Current: 600/544
• CPC Class Codes: A61B 5/301 providing electrical separation, e.g. by using isolating transformers or optocouplers
• CPC Class Codes: A61B 5/319 Circuits for simulating ECG signals
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

During open-heart surgery an EEG (electroencephalograph) system detects a patient'"'"'s brain waves, amplifies the brain wave signals and converts them into digital data. The cardiopulmonary bypass pump (heart-lung machine) is connected to blood flow and blood temperature transducers whose measurements, in digital form, are used to calculate a standard of normal electro-physiological responses to blood flow and temperature changes with which the patient'"'"'s actual brain wave responses will be compared. A visual display indicates to the surgical team, as to each of eight brain sectors, whether the patient'"'"'s brain waves show that remedial action may be required. The digitalized brain wave signals, after processing to reduce muscle artifact and other noise, are displayed, in one embodiment, as intensity modulated time segments, using a moving window type of display in which the current segment is statistically compared to the group of immediate prior segments to provide a current self-norm (NORMS n). A new display (NORMS n+ 1) is started when a statistically meaningful different segment occurs and comparison is made and displayed between the two displays (NORMS n+ 1 and NORMS n). In another embodiment the same comparison of the groups is made, but the visual display utilizes a set of color-coded lights in the eight sectors of the display.

Claims

1. An electroencephalograph (EEG) system which is used intra-operatively in open-heart surgery in which the patient'"'"'s blood is pumped and oxygenated by a cardiovascular bypass, including

perfusion blood flow means and perfusion blood temperature means to respectively measure the patient'"'"'s blood flow and temperature in the cardiovascular bypass and produce respective corresponding signals;

brain wave signal means comprising a series of electrodes adapted to be connected to the patient'"'"'s head to produce signals representing the patient'"'"'s brain waves, amplifiers connected to the electrodes, and analog/digital conversion means connected to the amplifiers to produce sets of digital data corresponding to the patient'"'"'s brain waves from a plurality of sectors of the patient'"'"'s head;

data analysis means connected to said blood flow means and said blood temperature means and said brain wave signal means to analyze the digitized brain wave signals based upon the following relationship which predicts the neurophysiological processes attributable to biophysical changes which occur with changes in said flow and temperature;

##EQU5## where T_N is the normal body temperature, T_P is the perfusion blood temperature, V_N is the normal perfusion volume, V_P is the current cardiovascular perfusion volume, A is a coefficient in the range of 0.4-0.6 and B is a coefficient in the range of 0.3-0.5.

2. An electroencephalograph system as in claim 1 wherein A is 0.5.