2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents

CAFC
  • US 4,572,909 A
  • Filed: 02/03/1984
  • Issued: 02/25/1986
  • Est. Priority Date: 03/11/1982
  • Status: Expired due to Term
First Claim
Patent Images

1. A dihydropyridine compound of the formula ##STR58## or a pharmaceutically acceptable acid addition salt thereof, wherein Y is --(CH2)2 --, --(CH2)3 --, --CH2 CH(CH3)-- or --CH2 C(CH3)2--;

  • R is aryl;

    R1 and R2 are each independently C1 -C4 alkyl or 2-methoxyethyl; and

    R3 is hydrogen, C1 -C4 alkyl, 2-(C1 -C4 alkoxy)ethyl, cyclopropylmethyl, benzyl, or --(CH2)m COR4 where m is 1, 2 or 3 and R4 is hydroxy, C1 -C4 alkoxy or --NR5 R6 where R5 and R6 are each independently hydrogen or C1 -C4 alkyl;

    wherein aryl is phenyl;

    phenyl substituted by one or two of nitro, halo, C1 -C4 alkyl, C1 -C4 alkoxy, hydroxy, trifluoromethyl or cyano;

    1-naphthyl;

    or 2-naphthyl.

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