2-(Secondary aminoalkoxymethyl) dihydropyridine derivatives as anti-ischaemic and antihypertensive agents
DC CAFC
First Claim
1. A dihydropyridine compound of the formula ##STR58## or a pharmaceutically acceptable acid addition salt thereof, wherein Y is --(CH2)2 --, --(CH2)3 --, --CH2 CH(CH3)-- or --CH2 C(CH3)2--;
- R is aryl;
R1 and R2 are each independently C1 -C4 alkyl or 2-methoxyethyl; and
R3 is hydrogen, C1 -C4 alkyl, 2-(C1 -C4 alkoxy)ethyl, cyclopropylmethyl, benzyl, or --(CH2)m COR4 where m is 1, 2 or 3 and R4 is hydroxy, C1 -C4 alkoxy or --NR5 R6 where R5 and R6 are each independently hydrogen or C1 -C4 alkyl;
wherein aryl is phenyl;
phenyl substituted by one or two of nitro, halo, C1 -C4 alkyl, C1 -C4 alkoxy, hydroxy, trifluoromethyl or cyano;
1-naphthyl;
or 2-naphthyl.
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Abstract
A dihydropyridine compound of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein
Y is --(CH2)2 --, --(CH2)3 --, --CH2 CH(CH3)-- or --CH2 C(CH3)2 --;
R is aryl or heteroaryl;
R1 and R2 are each independently C1 -C4 alkyl or 2-methoxyethyl; and
R3 is hydrogen, C1 -C4 alkyl, 2-(C1 -C4 alkoxy)ethyl, cyclopropylmethyl, benzyl, or --(CH2)m COR4 where m is 1, 2 or 3 and
R4 is hydroxy, C1 -C4 alkoxy or --NR5 R6 where R5 and R6 are each independently hydrogen or C1 -C4 alkyl
can be employed for treating or preventing a heart condition or hypertension.
170 Citations
17 Claims
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1. A dihydropyridine compound of the formula ##STR58## or a pharmaceutically acceptable acid addition salt thereof, wherein Y is --(CH2)2 --, --(CH2)3 --, --CH2 CH(CH3)-- or --CH2 C(CH3)2--;
R is aryl;
R1 and R2 are each independently C1 -C4 alkyl or 2-methoxyethyl; and
R3 is hydrogen, C1 -C4 alkyl, 2-(C1 -C4 alkoxy)ethyl, cyclopropylmethyl, benzyl, or --(CH2)m COR4 where m is 1, 2 or 3 and R4 is hydroxy, C1 -C4 alkoxy or --NR5 R6 where R5 and R6 are each independently hydrogen or C1 -C4 alkyl;
wherein aryl is phenyl;
phenyl substituted by one or two of nitro, halo, C1 -C4 alkyl, C1 -C4 alkoxy, hydroxy, trifluoromethyl or cyano;
1-naphthyl;
or 2-naphthyl.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
Specification
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- Resources
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Current AssigneePfizer Inc.
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Original AssigneePfizer Inc.
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InventorsCross, Peter E., Campbell, Simon F., Stubbs, John K.
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Primary Examiner(s)Jiles, Henry R.
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Assistant Examiner(s)Bjorkman, Dale A.
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Application NumberUS06/576,982Time in Patent Office753 DaysField of Search544/333, 546/321, 546/283, 546/274, 546/280, 546/257, 546/271, 546/167, 546/284, 546/270, 424/251, 424/258, 424/266, 514/356US Class Current514/356CPC Class CodesA61P 9/06 AntiarrhythmicsA61P 9/10 for treating ischaemic or a...A61P 9/12 AntihypertensivesC07C 247/00 Compounds containing azido ...C07D 209/48 with oxygen atoms in positi...C07D 211/90 Carbon atoms having three b...C07D 401/12 linked by a chain containin...Y02P 20/55 Design of synthesis routes,...
