Polycarbonate-polyether-copolymer membrane

• US 4,686,044 A
• Filed: 12/09/1985
• Issued: 08/11/1987
• Est. Priority Date: 08/13/1979
• Status: Expired due to Fees

• Current Assignee: Akzo Nobel N.V. (Nouryon BV)
• Original Assignee: Akzo Nobel N.V. (Nouryon BV)
• Inventors: Behnke, Joachim, Pitowski, Hans-Jurgen
• Primary Examiner(s): KENDELL, LORRAINE
• Application Number:
  US06/807,766
• Time in Patent Office: 610 Days
• Field of Search: 428/398, 428/376, 428/978, 210/500.2, 210/500.1, 210/500.21, 210/500.22, 210/500.23, 210/500.27, 264/41, 264/45.9, 264/176 F, 264/178 F, 264/181, 264/209.1
• US Class Current: 210/500.22
• CPC Class Codes: B01D 63/02 Hollow fibre modules
• CPC Class Codes: B01D 69/02 characterised by their properties
• CPC Class Codes: B01D 71/50 Polycarbonates
• CPC Class Codes: B01D 71/52 Polyethers
• CPC Class Codes: B01D 71/80 Block polymers
• CPC Class Codes: C08G 64/183 containing polyether sequences
• CPC Class Codes: Y10T 428/2975 Tubular or cellular

Abstract

A method is provided for producing a membrane from polycarbonate-polyether-blockcopolymers with about 5 to 35 weight percent of repeating alkyleneethercarbonate units and about 95 to 65 weight percent of repeating bisphenol A-carbonate units, wherein the polyethyleneoxide blocks have a molecular weight from about 1,000 to 20,000, wherein the intrinsic viscosity of the copolymer is from about 180 to 300 ml/g as measured in chloroform at 25° C. and wherein the ultrafiltration rate is from about 4 to 200 ml/h.m².mm Hg. In a first dissolving step a polycarbonate-polyether-copolymer is homogeneously mixed with a solvent at a temperature from about 80° to 120° C. and in a second dissolving step the temperature is brought to about 140° to 180° C. to produce a true solution. The filtered solution is cooled to from about 20° to 50° C. and is then extruded through a nozzle into a bath comprising a nonsolvent for the polymer for precipitating the polymer. The precipitated polymer is then washed and dried. The resulting membranes improve the processes of hemodialyzing and of homofiltration.

Claims

1. An isotropic polycarbonate-polyether block copolymer membrane useful for hemodialysis, containing less than 0.5 weight percent impurities consisting essentially of

(1) about 5 to 35 weight percent of repeating polyethylene-ether-carbonate units, the polyethylene oxide blocks of said copolymer having a molecular weight of from 1000 to 20,000, and

(2) about 95 to 65 weight percent of repeating bisphenol A - carbonate units wherein the intrinsic viscosity of said copolymer ranges from about 180 to 300 ml/g as measured in chloroform at 25°

C., and

the ultrafiltration rate of said membrane amounts to about 4 to 200 ml/h.m² mmHg, said membrane being prepared by a wet extrusion process.

2. The membrane according to claim 1 formed as a flat foil.

3. The membrane according to claim 1 formed as a tubular foil.

4. The membrane according to claim 1 formed as a hollow fiber.

5. The membrane according to claim 1 wherein numerically the dialytical permeability DL_B12 for vitamine B 12 (as measured at 20°

C.) depends on the ultrafiltration efficiency UFL according to the formula ##EQU6##

6. The membrane according to claim 1 wherein the polycarbonate-polyether-copolymer comprises from about 7 to 13 weight percent of repeating polyethyleneoxide-carbonate units, wherein the average molecular weight of the polyethyleneoxide-carbonate blocks is from about 6,000 to 10,000, and from about 93 to 87 weight percent of repeating bisphenol A-carbonate units.

7. An isotropic polycarbonate-polyether block copolymer membrane useful for hemodialysis, containing less than 0.5 weight percent impurities consisting essentially of

(1) about 5 to 35 weight percent of repeating polyethylene-ether-carbonate units, the polyethylene oxide blocks of said copolymer having a molecular weight of from 1000 to 20,000, and

(2) about 95 to 65 weight percent of repeating bisphenol A - carbonate units wherein the intrinsic viscosity of said copolymer ranges from about 180 to 300 ml/g as measured in chloroform at 25°

C., and

The ultrafiltration rate of said membrane amounts to about 4 to 200 ml/h.m² mmHg, said membrane being prepared by a wet extrusion process comprising the following steps;

(a) dissolving said polycarbonate - polyether block copolymer in a solvent therefor at a temperature of from about 80°

-120°

C.,

(b) increasing the temperature of said solution to about 140°

-180°

C.,

(c) filtering said solution,

(d) cooling said filtered solution to about 20°

-50°

C.,

(e) extruding said solution through a nozzle into a bath containing a non-solvent for the copolymer for precipitating the polymer, and

(f) drying the extruded precipitated polymer in the presence of measures for preventing longitudinal and cross-sectional shrinkage.

8. The membrane according to claim 7 in the form of a flat foil.

9. The membrane according to claim 7 in the form of a tube.

10. The membrane according to claim 7 in the form of a hollow fiber.

11. The membrane according to claim 7 wherein numerically the dialytical permeability DL_B12 for Vitamin B 12 (measured at 20°

C.) depends on the ultrafiltration efficiency UFL according to the formula ##EQU7##

12. The membrane according to claim 7 wherein said polycarbonate-polyether copolymer consists assentially of (1) about 7 to 13 weight percent of repeating polyethylene oxide-carbonate units, wherein the average molecular weight of the polyethylene oxide-carbonate blocks is from about 6,000 to 10,000, and (2) about 93 to 87 weight percent of repeating bisphenol A-carbonate units.