Thiazolidinedione derivatives, useful as antidiabetic agents

• US 4,687,777 A
• Filed: 01/17/1986
• Issued: 08/18/1987
• Est. Priority Date: 01/19/1985
• Status: Expired due to Term

• Current Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Original Assignee: Takeda Chemical Industries, Ltd. (Takeda Pharmaceutical Company Limited)
• Inventors: Fujita, Takeshi, Meguro, Kanji
• Primary Examiner(s): Jiles, Henry R.
• Assistant Examiner(s): RICHTER, JOHANN R
• Application Number:
  US06/820,390
• Time in Patent Office: 578 Days
• Field of Search: 546/280, 514/342
• US Class Current: 514/342
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: C07D 213/30 Oxygen atoms
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links

Abstract

Thiazolidinedione derivatives of the formula: ##STR1## and pharmacologically acceptable salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for treatment of diabetes and hyperlipemia.

Claims

1. A compound of the formula:

##STR15## or a pharmacologically acceptable salt thereof.

2. A compound as claimed in claim 1, wherein the compound is 5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione.

3. A compound as claimed in claim 1, wherein the compound is sodium salt of 5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzylbenzyl}-2,4-thiazolidinedione.

4. A compound as claimed in claim 1, wherein the compound is 5-{4-[2-(6-ethyl-2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione.

5. An antidiabetic composition which consists essentially of a compound of the formula:

##STR16## or a pharmacologically acceptable salt thereof, in association with a pharmacologically acceptable carrier, excipient or diluent.