Blood glucose monitor

• US 4,704,029 A
• Filed: 12/26/1985
• Issued: 11/03/1987
• Est. Priority Date: 12/26/1985
• Status: Expired due to Fees

• Current Assignee: New Mexico State University Technology Transfer Corporation
• Original Assignee: Research Corporation
• Inventors: Van Heuvelen, Alan
• Primary Examiner(s): ROSENBERGER, RICHARD A
• Application Number:
  US06/813,742
• Time in Patent Office: 677 Days
• Field of Search: 356/39, 356/135, 356/136, 356/137, 356/344, 128/633, 422/68, 436/95
• US Class Current: 356/39
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/6876 Blood vessel
• CPC Class Codes: A61B 5/6884 Clamps or clips
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G01J 2001/1636 one detector directly monitoring the source, e.g. also impulse time controlling
• CPC Class Codes: G01N 21/21 Polarisation-affecting properties G01N21/19 takes precedence
• CPC Class Codes: G01N 21/43 by measuring critical angle
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

A blood glucose monitor which is particularly applicable for use as an implant for controlling an insulin pump, or as a portable device for use by a diabetic for home blood glucose monitoring. The glucose monitor measures the glucose level of blood by utilizing a refractometer which measures the index of refraction of blood adjacent to an interface with a transparent surface of the refractometer, by directing light at the interface to measure the index of refraction of the blood by the amount of radiation reflected by the interface, particularly light incident near the critical angle. In a preferred embodiment, polarized light is directed against an interface in an implant between a transparent material and the blood. As the glucose concentration in the blood changes, its index of refraction changes, as does the intensity of light reflected from the interface. The angle of incidence of the light is selected to be slightly less than the critical angle for total internal reflection, with the result that the reflected intensity varies dramatically with index of refraction and with glucose concentration. A differential amplifier compares the intensity of the light reflected from the blood and the intensity of the beam before reflection. The output signal from the differential amplifier indicates only a change in the intensity of the reflected light caused by a change in the glucose concentration from a standard setting.

Claims

1. A method of measuring the glucose level in blood, comprising:

a. positioning an optical interface with one surface thereof in direct contact with the blood;

b. measuring the index of refraction of the blood adjacent to the optical interface by directing a polarized radiation beam at the interface at an angle of incidence slightly less than the critical angle of incidence of the radiation beam relative to the optical interface, and measuring the radiation level of radiation reflected from the interface, which depends upon the index of refraction of the blood adjacent to the interface; and

c. removing albumin in the blood from the interface to remove the effect of albumin on the index of refraction measurement by applying an electric field to the blood at the interface to remove albumin from the interface.

2. A method of measuring the glucose level in blood as claimed in claim 1, wherein said step of directing a radiation beam includes directing a radiation beam at a wavelength near the wavelength of a glucose absorption band.

3. A method of measuring the glucose level in blood as claimed in claim 1, wherein said step of directing a radiation beam includes directing a radiation beam having two different wavelengths of radiation.

4. A method of measuring the glucose level in blood as claimed in claim 1, including the steps of splitting off a portion of said radiation beam, prior to it being directed at the interface, to form a reference beam, measuring the radiation level of the reference beam, and differentially comparing the measured reference beam with the measured reflected radiation.

5. A method of measuring the glucose level in blood as claimed in claim 1, wherein said step of measuring the reflected radiation is performed with a photodiode.

6. A method of measuring the glucose level in blood as claimed in claim 1, wherein said step of measuring the reflected radiation is performed with an array of photodetectors.

7. A method of measuring the glucose level in blood as claimed in claim 1, wherein said step of directing a radiation beam includes positioning a reflective surface parallel to and adjacent to said optical interface, and directing the radiation beam to perform multiple reflections between the optical interface and the reflective surface.

8. A device for measuring the glucose level in blood, comprising:

a. said device having an optical interface which is positioned with one surface thereof in direct contact with the blood; and

b. means for directing a polarized radiation beam at the optical interface at an angle of incidence slightly less than the critical angle of incidence of the radiation beam relative to the optical interface;

c. means for measuring the radiation level of radiation reflected from the interface, which depends upon the index of refraction of the blood adjacent to the interface and provides a measurement thereof; and

d. means for removing albumin in the blood from the interface to remove the effect of abuminin on the radiation level measurement, including means for applying an electric field to the blood at the interface to remove albumin from the interface.

9. A device for measuring the glucose level in blood as claimed in claim 8, wherein said means for directing a radiation beam directs a radiation beam at a wavelength near the wavelength of a glucose absorption band.

10. A device for measuring the glucose level in blood as claimed in claim 8, wherein said means for directing a radiation beam directs a radiation beam having two different wavelengths of radiation, and said means for measuring includes a separate measuring means for each different wavelength.

11. A device for measuring the glucose level in blood as claimed in claim 8, including a beam splitter for splitting off a portion of said radiation beam, prior to it being directed at the interface, to form a reference beam, and means for measuring the radiation level of the reference beam, and means for differentially comparing the measured reference beam with the measured reflected radiation.

12. A device for measuring the glucose level in blood as claimed in claim 8, wherein said measuring means includes an array of photodetectors.

13. A device for measuring the glucose level in blood as claimed in claim 8, wherein said means for directing a radiation beam includes a reflective surface positioned parallel to and adjacent to said optical interface, and the radiation beam is directed to perform multiple reflections between the optical interface and the reflective surface.