Implantable gas-containing biosensor and method for measuring an analyte such as glucose
First Claim
1. A device for sensing a product or reactant of an enzyme reaction with an analyte as a measure of the analyte comprisinga gas and enzyme permeable membrane having opposed sides,an enzyme on one side of said membrane for permeation through said membrane and enzymatic reaction with the analyte in presence of oxygen to provide the product or reactant,a closed container for containing oxygen on the enzyme side of said membrane to supply oxygen through said membrane for the enzymatic reaction, andmeans for sensing the product or reactant as a function of the analyte.
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Abstract
The present invention relates to a novel implantable biosensor and method for sensing products, such as hydrogen peroxide, generated from an enzymatic reaction between an analyte, like glucose, and an enzyme in the presence of oxygen. The novel implantable biosensor is uniquely equipped with an enclosed chamber for containing oxygen and can be adapted for extracting oxygen from animal tissue adjacent the container. The reservoir of oxygen contained in the enclosed chamber is supplied to the enzymatic reaction from both sides of a membrane. The enclosed chamber is uniquely designed to be impermeable to substances, like liquid and cells, that possibly can interfere with the supply of the oxygen permeating through the membrane to the enzymatic reaction. Also, the implantable biosensor is designed to optically or electrically sense products generated from the enzymatic reaction which serve as a function of the analyte.
1127 Citations
28 Claims
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1. A device for sensing a product or reactant of an enzyme reaction with an analyte as a measure of the analyte comprising
a gas and enzyme permeable membrane having opposed sides, an enzyme on one side of said membrane for permeation through said membrane and enzymatic reaction with the analyte in presence of oxygen to provide the product or reactant, a closed container for containing oxygen on the enzyme side of said membrane to supply oxygen through said membrane for the enzymatic reaction, and means for sensing the product or reactant as a function of the analyte.
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23. A device for sensing a product or reactant of an enzyme reaction with an analyte in presence of oxygen which functions as a measure of the analyte comprising
an enclosed chamber adapted for containing oxygen and enzyme comprising a wall structure defining a hollow interior, a portion of the wall structure being adapted for allowing oxygen and enzyme to permeate therethrough to supply oxygen and enzyme for the enzymatic reaction, an analyte permeable membrane overlying said portion of the wall structure and connected to said chamber for allowing the analyte to permeate therethrough to supply the analyte for the enzymatic reaction, and means for sensing the product or reactant of the enzymatic reaction which functions as a measure of the analyte.
Specification