Method of passive immunization of mammals using avian antibody

• US 4,748,018 A
• Filed: 06/19/1984
• Issued: 05/31/1988
• Est. Priority Date: 02/07/1984
• Status: Expired due to Term

• Current Assignee: Arkion Life Sciences
• Original Assignee: Stolle Research & Development Corporation
• Inventors: Stolle, Ralph J., Beck, Lee R.
• Primary Examiner(s): Hazel, Blondel
• Application Number:
  US06/622,130
• Time in Patent Office: 1,442 Days
• Field of Search: 424/85-92
• US Class Current: 424/157.1
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 2039/507 Comprising a combination of two or more separate antibodies
• CPC Class Codes: A61K 2039/542 oral/gastrointestinal
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: C07K 16/02 from eggs
• CPC Class Codes: C07K 16/04 from milk
• CPC Class Codes: C07K 16/1275 from Streptococcus (G)
• CPC Class Codes: C07K 2317/23 from birds

Abstract

A method of passively immunizing a mammal against a condition caused by an antigen comprising: administering to the mammal immunizing amounts of an antibody obtained from a domesticated fowl which has been immunized against the antigen; the mammal being tolerant to the antibody by virtue of having a history of consumption of antibody containing material derived from the egg of a fowl.

Claims

1. A method of passive immunization of a mammal against a condition caused by an antigen, which comprises:

(a) feeding said mammal a material, said material comprising heterologous protein antibody, having an enhanced antibody titer against said antigen obtained from the egg of a domesticated fowl immunized against said antigen, until said mammal develops substantial tolerance to said antibody; and

(b) administering to said mammal an immunologically effective amount of an antibody obtained from a domesticated fowl immunized against said antigen.

2. The method of claim 1 wherein, in said step (a), said mammal is fed whole eggs.

3. The method of claim 1 wherein, in said step (a), said mammal is fed egg yolk.

4. The method of claim 1 wherein, in said step (b), said administration is by injection.

5. The method of claim 1 wherein the condition caused by the antigen is dental caries.

6. The method of claim 1 wherein the condition caused by the antigen is dental plaque.

7. The method of claim 1 wherein, in said step (a), said eggs have an enhanced antibody titer against a multiplicity of antigens including said antigen.

8. The method of claim 1 wherein, in said step (b), said fowl is the same individual as the one used in step (a).

9. The method of claim 1 wherein, in said step (b), said domesticated fowl is a different individual as the one used in said step (a).

10. The method of claim 1 wherein said mammal is a non-human mammal.

11. The method of claim 10 wherein said mammal is selected from the group consisting of a rabbit, a bovid, a horse, a goat, a sheep, an ape, and a monkey.

12. The method of said claim 1 wherein said mammal is a human being.

13. The method of claim 1 wherein said antigen is a bacterial species, product of a bacterial species, or a combination of bacterial species.

14. The method of claim 1 wherein said antigen is a viral species, product of a viral species, or a combination of viral species.

15. The method of claim 1 wherein said antigen is a bioregulatory substance.

16. The method of claim 15 wherein said bioregulatory substance is a hormone, enzyme, or immune-regulatory factor.

17. The method of claim 1 wherein said antigen is a polypeptide.

18. The method of claim 17 wherein said polypeptide is snake venom toxin or bee venom toxin.

19. The method of claim 1 wherein said passive immunization is preventive.

20. The method of claim 1 wherein said passive immunization is paliative.

21. The method of claim 1 wherein, in step (a), said material is fed to said mammal together with material having an enhanced antibody titer against said antigen obtained from the milk of a bovid immunized against said antigen.

22. The method of any of claims 1 or 21 wherein, in step (b), said antibody is administered to said mammal together with antibody purified from milk of a bovid immunized against said antigen, and wherein said combination of antibodies is administered in an immunologically effective amount.

23. The method of claim 22 wherein said administration is by injection.

24. The method of claim 1 wherein said domesticated fowl in steps (a) and (b) is a chicken.

25. The method of claim 1 wherein, in step (b), said antibody is purified from the egg of said domesticated fowl.