Spring driven infusion pump

• US 4,772,263 A
• Filed: 09/23/1987
• Issued: 09/20/1988
• Est. Priority Date: 02/03/1986
• Status: Expired due to Term

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Buchwald, Henry, Dorman, Frank D.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Kartchner, Gene B.
• Application Number:
  US07/102,778
• Time in Patent Office: 363 Days
• Field of Search: 604/131-132, 604/134, 604/138, 604/151, 604/153, 604/891.1
• US Class Current: 604/132
• CPC Class Codes: A61M 2005/14264 with means for compensating influence from the environment
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1454 spring-actuated, e.g. by a clockwork
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

An implantable infusion pump (20) for infusing drugs or other chemicals or solutions into the body. A flexible spring diaphragm (25) forms an outer back wall portion (26) of a housing (22) of the infusion pump (20). The spring diaphragm (25) applies substantially constant force over a range of displacement and communicating internal body pressure to the drug chamber (30) so as to maintain a substantially uniform pressure difference between the drug chamber (30) and the internal body pressure.

Claims

1. An infusion pump for implantation in a living body, comprising:

(a) a housing having a variable volume drug chamber;

(b) spring energy source means being the principle force means for forcing drug solution out of the drug chamber into the body and compensating for changes in internal body pressure whereby pressure differential between the drug chamber and internal body pressure remains constant despite changes in body temperature or atmospheric pressure;

(c) an inlet conduit located at a first position on the housing in communication with the drug chamber;

(d) an outlet conduit located in a second position on the housing in communication with the drug chamber and leading to an infusion site in the living body, the outlet conduit including flow resistance means for resisting drug solution flow and means for delivery of the drug to the desired site; and

(e) a self-sealing penetrable member positioned in the inlet conduit, the self-sealing penetrable member being unobstructed so that the infusion pump can be implanted in the body with the unobstructed self-sealing penetrable member situated adjacent a surface area of the body whereby the drug chamber can be refilled with drug solution periodically by injection through the skin.

2. An infusion pump in accordance with claim 1, wherein the spring energy source means includes spring means for exerting a predetermined substantially constant force over a predetermined range of movement.

3. An infusion pump in accordance with claim 2, wherein the spring means includes spring diaphragm means for forming a movable external wall portion of the housing.

4. An infusion pump in accordance with claim 3, wherein the spring diaphragm means includes a conical spring member.

5. An infusion pump in accordance with claim 3, wherein the spring diaphragm means includes a plurality of conical spring sections interconnected by more stiff ring sections forming a spring diaphragm member.

6. An infusion pump in accordance with claim 3, wherein the spring diaphragm means includes a plurality of conical spring sections alternated radially with stronger conical sections reversely oriented.

7. An infusion pump for implantation in a living body;

comprising;

(a) a housing having a strong external shell structure;

(b) movable spring diaphragm means forming a portion of the external shell structure and cooperating with the remainder of the shell structure for providing a variable volume, drug chamber for holding a drug solution, the spring diaphragm means being acted on and being responsive to internal body pressure so as to provide a substantially uniform pressure differential between the drug chamber and the internal body pressure, the movable spring diaphragm means being the principal force means for forcing the drug solution from the drug chamber into the body; and

(c) means for delivering the drug solution to the body from the drug chamber.

8. An infusion pump in accordance with claim 7, wherein the spring diaphragm means exerts a substantially constant force over a predetermined range of movement.

9. An infusion pump in accordance with claim 8, wherein the infusion pump includes means for limiting movement of the spring diaphragm means whereby the spring diaphragm means is limited to a range of movements wherein the spring diaphragm means exerts a substantially constant force.

10. An infusion pump in accordance with claim 8, wherein the spring diaphragm means includes a plurality of conical spring sections radially spaced apart and interconnected by relatively stiff sections having a higher elastic constant than the conical spring sections.

11. An infusion pump in accordance with claim 10, wherein the spring diaphragm means exerts a force of 4 to 15 psi on the drug solution in the drug chamber.

12. An infusion pump in accordance with claim 10, wherein the spring diaphragm means is moveable between a first position and a second position, the spring diaphragm means being stressed at both positions so as to exert a substantially constant force over its range of movement between the first and second positions.

13. An infusion pump for implantation in a living body, comprising:

(a) a housing defining a variable volume, fluid tight drug chamber;

(b) moveable spring diaphragm means forming a wall portion of the drug chamber for exerting a force on the drug solution in the drug chamber, the spring means further forming an exterior wall portion of the housing and being subjected to a force exerted by internal body pressure, whereby changes in body pressure cause corresponding changes in the amount of force applied by the spring diaphragm means on the drug solution in the drug chamber, the spring diaphragm means including plurality of conical sections radially spaced apart and interconnected by sections having a higher elastic constant so as to provide a substantially constant force over a predetermined range of movement;

(c) inlet conduit means for providing fluid communication between the drug chamber and an exterior of the housing;

(d) outlet conduit means for providing fluid communication between the drug chamber and an infusion site in the body; and

(e) a self-sealing, penetrable member in the inlet conduit means, the self-sealing, penetrable member being unobstructed so that the pump can be implanted in the body with the unobstructed penetrable member situated adjacent a surface area of the body whereby the drug chamber can be refilled with drug solution periodically by injection through the skin.

15. An infusion pump in accordance with claim 13, wherein the spring diaphragm means is the principal force means for forcing the drug solution out of the drug chamber.

14. The method of infusing liquids into a living body, a method comprising:

(a) implanting a self-powered pump including spring diaphragm means into a living body, with an inlet conduit leading to a drug chamber of the pump;

(b) interconnecting an outlet conduit to at least one infusion site in the body;

(c) injecting drug solution through skin of the body and through a self-sealing, penetrable member positioned in the inlet conduit to fill the drug chamber; and

(d) exerting a force on the drug solution in the drug chamber corresponding to the cumulative total force of the spring diaphragm means and the internal body pressure whereby pressure differential between the drug chamber and the internal body pressure is maintained relatively constant, the force being exerted by the spring diaphragm means being the principal force for forcing the drug solution out of the drug chamber into the body.