Noninvasive reflectance oximeter

• US 4,796,636 A
• Filed: 09/10/1987
• Issued: 01/10/1989
• Est. Priority Date: 09/10/1987
• Status: Expired due to Term

• Current Assignee: Colin Electronics Co., Ltd.
• Original Assignee: Nippon Colin Company Limited
• Inventors: Edgar, Reuben W. Jr., Branstetter, Ronald L.
• Primary Examiner(s): Wayner, William E.
• Application Number:
  US07/095,125
• Time in Patent Office: 488 Days
• Field of Search: 128/633, 128/691, 356/41, 356/42
• US Class Current: 600/330
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: G01N 21/3151 using two sources of radiation of different wavelengths G01N21/33 - G01N21/39 take precedence

Abstract

A noninvasive optical oximeter for measuring oxygen saturation of arterial blood. A sample of blood is illuminated with light at two different wavelengths. Light reflected by the blood is sensed by a photodetector and an output signal is created in response thereto. The output signal is processed to form a quotient representing the AC components of the reflected light at each wavelength. The oxygen saturation of the blood is calculated by correlating this quotient with an oxygen saturation reference curve uniquely representative of the blood oxygen saturation characteristics of a particular individual. The reference curve used in the preferred embodiment of the invention is calibrated in a two-step process which minimizes the effects of calibration errors. A first oxygen saturation reference curve is calculated which is based on a linear relationship between the ratio of the AC components of the reflected light. This curve is then used to calibrate a second reference curve based on a linear ratio of the squared values of the AC components of the reflected light. Once the second reference curve has been properly calibrated, it is used for all subsequent measurements of oxygen saturation.

Claims

1. A blood oxygen saturation monitoring system comprising:

a first source of electromagnetic radiation at a first wavelength;

a second source of electromagnetic radiation at a second wavelength;

means for positioning said first and second sources of electromagnetic radiation to illuminate a sample of blood;

sensing means for receiving electromagnetic radiation reflected by said sample of blood, said reflected electromagnetic radiation comprising an AC component and a DC component, said sensing means producing an output signal corresponding only to the AC components of the reflected portions of said first and second electromagnetic radiation;

means for producing a quotient of squared values of said AC voltage components;

means for calculating blood oxygen saturation by correlating said quotient of said squared AC components with an oxygen saturation reference curve, said reference curve being uniquely representative of the blood oxygen saturation characteristics of a particular individual.

2. The monitoring system according to claim 1, wherein said first and second sources of electromagnetic radiation comprise first and second light emitting diodes.

3. The monitoring system according to claim 2, wherein said first light emitting diode provides light having a wavelength corresponding to red and said second light emitting diode provides light having a wavelength corresponding to infrared.

4. The monitoring system according to claim 3, wherein said first reference curve is defined by first and second data points, said first data point comprising a quotient calculated using optical properties of blood for said first wavelength, said second data point being a unique oxygen saturation point for said particular individual.

5. The monitoring system according to claim 4, wherein said first data point is defined by a quotient comprising values for the absorption coefficient for reduced hemoglobin for red light and the absorption coefficient for oxygenated hemoglobin for red light.

6. The monitoring system according to claim 5, wherein said second data point is defined by a unique blood oxygen saturation point for said particular individual.

7. A blood oxygen saturation monitoring system comprising:

a first light emitting diode for producing light at a first wavelength;

a second light emitting diode for producing light at a second wavelength;

means for positioning said first and second light emitting diodes to illuminate a sample of blood;

sensing means for receiving light reflected by said sample of blood, said reflected light comprising an AC component and a DC component, said sensing means producing an output signal corresponding only to the AC components of said reflected light at said first and second wavelengths;

means for calculating a first reference curve comprising a linear relationship between the ratio of said AC voltage components, said reference curve being defined by first and second data points, said first data point corresponding to a quotient of absorption coefficients of light at said first wavelength, said second data point being a unique data point corresponding to oxygen saturation characteristics of a particular individual;

means for calculating a second reference curve defined a linear relationship between squared values of said AC voltage components, said second reference curve being defined by third and fourth data points, said third data point being a data point calculated using said first reference curve, said fourth data point being defined by a quotient of absorption coefficients of light at said first wavelength; and

means for calculating blood oxygen saturation by correlating said quotient of said squared values of said AC voltage components with said second oxygen saturation reference curve.

8. The monitoring system according to claim 7, wherein said third data point is in the range of 88 to 92 percent oxygen saturation.

9. The monitoring system according to claim 8, wherein said first light emitting diode provides light having a wavelength corresponding to red and said second light emitting diode provides light having a wavelength corresponding to infrared.

10. The monitoring system according to claim 9, wherein said first wavelength of light is approximately 660 nm and said second wavelength of light is approximately 900 nm.

11. The monitoring system according to claim 9, wherein said first data point is defined by a quotient comprising values for the absorption coefficient for reduced hemoglobin for red light and the absorption coefficient for oxygenated hemoglobin for red light.

12. The monitoring system according to claim 11, wherein said second data point is defined by a unique 98% blood oxygen saturation point for said particular individual.

13. A method for determining the oxygen saturation of arterial blood, comprising the steps of:

illuminating a sample of said blood with electromagnetic radiation at a first wavelength;

illuminating said sample of blood with electromagnetic radiation at a second wavelength;

collecting electromagnetic radiation reflected by said sample of blood, said radiation comprising an AC and a DC component, and developing therefrom an electrical signal representing only the alternating current components of said reflected radiation at said first and second wavelengths;

calculating a first reference curve comprising a linear relationship between the ratio of said AC voltage components, said reference curve being defined by first and second data points, said first data point correponding to a quotient of absorption coefficients of light at said first wavelength, said second data point being a unique data point corresponding to oxygen saturation characteristics of a particular individual;

calculating a second reference curve defined a linear relationship between squared values of said AC voltage components, said second reference curve being defined by third and fourth data points, said third data point being a data point calculated using said first reference curve, said fourth data point being defined by a quotient of absorption coefficients of light at said first wavelength; and

calculating blood oxygen saturation by correlating said quotient of said squared values of said AC voltage components with said second oxygen saturation reference curve.

14. The method according to claim 13, wherein said third data point is in the range of 88 to 92 percent oxygen saturation.

15. The method according to claim 14, wherein said radiation at said first and second wavelengths is produced by first and second light emitting diodes, respectively.

16. The method according to claim 15, wherein said first and second wavelengths of light are approximately 660 nm and 900 nm, respectively.

17. The method according to claim 16, wherein said first data point is defined by a quotient comprising values for the absorption coefficient for reduced hemoglobin for red light and the absorption coefficient for oxygenated hemoglobin for red light.

18. The monitoring system according to claim 17, wherein said second data point is defined by a unique 98% blood oxygen saturation point for said particular individual.