Blood electrolyte sensors including crosslinked polyetherurethane membranes
First Claim
1. A sensor for blood analysis comprising a sensing element for an electrolyte in a blood stream and a crosslinked polyetherurethane membrane permeable to said electrolyte but impermeable to other components of said blood stream so that, when the sensor is in the blood stream, the membrane prevents contact between said sensing element and said other components, said membrane comprising a crosslinked polyetherurethane composition having a hard segment of from 20 to 50%, said composition comprising a product from the reaction of a diisocyanate, polyethylene oxide, a chain extending diol of from 2 to 10 carbon atoms and a trihydroxy crosslinking agent of 2 to 10 carbon atoms, said membrane absorbing from 50 to 120% of its dry weight of water, said sensing element being capable of generating a detectable signal in response to contact with said electrolyte.
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Accused Products
Abstract
Partition membranes which are permeable to blood electrolytes fabricated from crosslinked polyetherurethane compositions having from 20 to 50% hard segments. The membranes absorb from 50 to 120% of their dry weight of water and have electrolyte diffusion constants of up to 1×10-6 cm2 /sec. The membranes are included in electrochemical, fiber optic and solid state blood electrolyte sensors to provide blood compatible surfaces and to ensure that blood components deleterious to analysis of electrolyte in the blood remain separated from the sensing elements.
59 Citations
10 Claims
- 1. A sensor for blood analysis comprising a sensing element for an electrolyte in a blood stream and a crosslinked polyetherurethane membrane permeable to said electrolyte but impermeable to other components of said blood stream so that, when the sensor is in the blood stream, the membrane prevents contact between said sensing element and said other components, said membrane comprising a crosslinked polyetherurethane composition having a hard segment of from 20 to 50%, said composition comprising a product from the reaction of a diisocyanate, polyethylene oxide, a chain extending diol of from 2 to 10 carbon atoms and a trihydroxy crosslinking agent of 2 to 10 carbon atoms, said membrane absorbing from 50 to 120% of its dry weight of water, said sensing element being capable of generating a detectable signal in response to contact with said electrolyte.
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10. A sensor for blood analysis comprising a sensing element which includes a field effect transistor sensitive to the pH of a blood stream and a crosslinked polyetherurethane membrane being capable of absorbing from 50-120% of its dry weight of water, said membrane being permeable to hydrogen ions in a blood stream but impermeable to other components of said blood stream so that, when the sensor is in the blood stream, the membrane prevents contact between said transistor and said other components, said membrane comprising a crosslinked polyetherurethane composition having a hard segment of from 20 to 50%, said composition comprising a product from the reaction of a diisocyanate, polyethylene oxide, a chain extending diol of from 2 to 10 carbon atoms and a trihydroxy crosslinking agent of 2 to 10 carbon atoms, said transistor being capable of generating a detectable signal consequent to a contact with said hydrogen ions.
Specification