Feedback-controlled method and apparatus for processing signals used in oximetry

• US 4,819,646 A
• Filed: 08/18/1986
• Issued: 04/11/1989
• Est. Priority Date: 08/18/1986
• Status: Expired due to Term

• Current Assignee: NELLCOR PURITAN BENNETT
• Original Assignee: Physio-Control Incorporated (Stryker Corporation)
• Inventors: Wagner, Darrell O., Smith, Robert E., Hunsaker, Scott W., Prosser, Stephen J., Gauglitz, Karl F., Cheung, Peter W., Mason, Lee R.
• Primary Examiner(s): Coven, Edward M.
• Assistant Examiner(s): Hanley, John C.
• Application Number:
  US06/897,664
• Time in Patent Office: 967 Days
• Field of Search: 128/633-634, 128/664-666, 356/41, 330/59, 330/308, 250/214 A
• US Class Current: 600/323
• CPC Class Codes: A61B 5/14551 for measuring blood gases

Abstract

A feedback control system is disclosed for use in processing signals employed in pulse transmittance oximetry. The signals are produced in response to light transmitted through, for example, a finger at two different wavelengths. Each signal includes a slowly varying baseline component representing the relatively fixed attenuation of light produced by bone, tissue, skin, and hair. The signals also include pulsatile components representing the attenuation produced by the changing blood volume and oxygen saturation within the finger. The signals are processed by the feedback control system before being converted by an analog-to-digital (A/D) converter (72) for subsequent analysis by a microcomputer (16). The feedback control system includes a controllable offset subtractor (66), a programmable gain amplifier (68), controllable drivers (44) for the light sources (40,42), and the microcomputer (16). The microcomputer receives signals from the offset subtractor (66), gain amplifier (68), drivers (44) and A/D converter (72) to produce signals that control the function of the subtractor (66) and drivers (44) in the following manner. Normally, the drivers (44) are maintained within a predetermined current range. In the event the microcomputer (16) senses an output from the converter (72) that is not within a predetermined range, the drive signal is adjusted to produce an acceptable signal. The magnitude of the offset removed by the subtractor (66), as controlled by the microcomputer (16), is maintained at a constant level when the converter (72) output is within a first predetermined range and is a predetermined function of the converter (72) output when that output falls within a second predetermined range.

Claims

1. A method of processing information signals that contain information about the oxygen saturation of arterial blood flowing in tissue, comprising the steps of:

subtracting from said information signal a controlled portion of said information signal, the magnitude of said controlled portion being determined by a subtraction control signal;

producing a subtraction output that is substantially equal to the portion of said information signal remaining after said controlled portion is subtracted therefrom; and

producing said subtraction control signal, the magnitude of said subtraction control signal produced being a function of said subtraction output and indicating any adjustment to be made in said controlled portion subtracted from said information signal.

2. The method of claim 1, wherein said information signal is produced by a detection means in response to light illuminating said tissue, said method further comprising the steps of:

adjusting the intensity of said light illuminating said detection means, the amount of adjustment being determined by a source control signal;

producing a source signal proportional to the intensity of said light transilluminating said detection means; and

producing said source control signal, the magnitude of said source control signal produced being a function of said source signal and indicating any adjustment to be made in the intensity of said light.

3. The method of claim 2, further comprising the steps of:

amplifying said subtraction output by a controlled gain, the magnitude of said gain being a function of a gain control signal;

producing an amplified output substantially equal to the product of said subtraction output and said gain; and

producing said gain control signal indicating the desired adjustment in said controlled gain.

4. An apparatus for receiving and processing signals, produced by a sensor, that contain information about the oxygen saturation of arterial blood flowing in tissue, said apparatus comprising:

offset subtraction means for subtracting from said sensor signal a controlled portion of said signal, said offset subtraction means having an output that is substantially equal to the portion of said sensor signal remaining after said controlled portion is subtracted therefrom;

control means for receiving said output of said offset subtraction means and providing a subtraction control signal, which is dependent on said output, to said subtraction means to control the magnitude of said portion of said sensor signal; and

analyzing means for receiving said output of said subtraction means and producing an indication of the oxygen saturation of said arterial blood flowing in said tissue.

5. The apparatus of claim 4, wherein said subtraction means subtracts the same said portion from said sensor signal when said subtraction means output is within a first predetermined range.

6. The apparatus of claim 5, wherein said subtraction means subtracts an adjusted said portion from said sensor signal when said subtraction means output falls within a second predetermined range, said magnitude of said adjusted portion being a function of the magnitude of said subtraction means output.

7. The apparatus of claim 6, wherein said subtraction means does not adjust said controlled portion subtracted from said sensor signal when the value of said subtraction means output exceeds a third predetermined level.

8. The apparatus of claim 7, wherein said controlled portion of said signal subtracted by said offset subtraction means is initialized at a predetermined value.

9. The apparatus of claim 4, wherein said subtraction means subtracts an adjusted said portion from said sensor signal when said subtraction means output falls within a predetermined range, said magnitude of said adjusted portion subtracted being a function of the magnitude of said subtraction means output.

10. The apparatus of claim 4, wherein said controlled portion of said signal subtracted by said offset subtraction means is initialized at a predetermined value.

11. The apparatus of claim 4, wherein said subtraction means output is in an analog format and said apparatus further comprises conversion means for converting said subtraction means output from said analog format into a digital format for receipt by said control means and said analyzing means.

12. The apparatus of claim 4, wherein said analyzing means adds said controlled portion of said signal back to said offset subtraction means output before producing said indication of oxygen saturation.

13. The apparatus of claim 4, further comprising a differential current-to-voltage amplifier for amplifying said signal produced by said sensor before said subtraction means subtracts said controlled portion therefrom.

14. The apparatus of claim 4, further comprising an amplifier for amplifying said subtraction means output by a controlled gain before said subtraction means output is received by said analyzing means, said control means producing an amplifier control signal that is received by said amplifier, which adjusts the controlled gain in response thereto.

15. The apparatus of claim 14, wherein said subtraction means output amplified by said controlled gain in an analog format and said apparatus further comprises conversion means for converting said amplified subtraction means output from said analog format into a digital format for receipt by said analyzing means.

16. The apparatus of claim 15, wherein said analyzing means is further for removing said gain from said amplified subtraction means output before producing said indication of oxygen saturation.

17. The apparatus of claim 14, wherein the sensor includes a source for exposing the tissue to light and said control means is further for producing a source control signal to control the intensity of the light.

18. The apparatus of claim 4, wherein the sensor includes a source for exposing the tissue to light and said control means is further for producing a source control signal to control the intensity of the light.

19. The apparatus of claim 18, wherein said source control signal further causes said signal produced by said sensor to fall within a predetermined sensor signal range.

20. The apparatus of claim 19, wherein said source control signal further causes said sensor signal to be adjusted when said subtraction means output is within a predetermined range.

21. An oximeter, comprising:

a controllable-intensity light source, responsive to a source control signal, for illuminating tissue having arterial blood flowing therein, the intensity of light with which said tissue is illuminated being determined by said source control signal;

detection means, responsive to the illumination of said tissue, for producing a signal containing information about the oxygen saturation of said arterial blood;

offset subtraction means, responsive to a subtraction control signal, for subtracting from said detection means signal a controlled portion of said signal, the magnitude of said controlled portion being determined by said subtraction control signal, said subtraction means having an output that is substantially equal to the portion of said detection means signal remaining after said controlled portion is subtracted therefrom;

a controllable-gain amplifier, responsive to a gain control signal, for amplifying said subtraction means output by a controlled gain, the magnitude of said gain being determined by said gain control signal, said amplifier having an output that is substantially equal to the product of said subtraction means output and said gain;

control means for producing said source control signal, said subtraction control signal, and said gain control signal, said source and subtraction control signals being predetermined functions of said amplifier output; and

analyzing means for receiving said amplifier output and producing an indication of the oxygen saturation of said arterial blood flowing in said tissue.

22. The oximeter of claim 21, wherein said light source adjusts the intensity of light illuminating said tissue in response to said source control signal when said amplifier output falls within a first predetermined range of amplifier outputs and said offset subtraction means adjusts said controlled portion of said detection means signal in response to said subtraction control signal when said amplifier output falls within a second predetermined range of amplifier outputs.

23. The oximeter of claim 22, wherein said amplifier output is in an analog format and said oximeter further comprises conversion means for converting said amplifier output from said analog format into a digital format for receipt by said control means and said analyzing means.

24. The oximeter of claim 23, wherein said analyzing means is further for removing said gain and adding said controlled portion back to said output of said amplifier before producing said indication of oxygen saturation.

25. The oximeter of claim 21, further comprising a differential current-to-voltage amplifier for amplifying said signal produced by said sensor means before said subtraction means subtracts said controlled portion therefrom.

26. The oximeter of claim 21, wherein said light source illuminates said tissue with red and infrared wavelength light in a predetermined manner.

27. The oximeter of claim 26, further comprising a red optical filter, interposed between said light source and said detection means, for filtering the illumination that said detection means responds to.