Gas sensor

• US 4,824,789 A
• Filed: 10/10/1986
• Issued: 04/25/1989
• Est. Priority Date: 10/10/1986
• Status: Expired due to Term

• Current Assignee: Terumo Cardiovascular Systems Corporation (Terumo Corporation)
• Original Assignee: Cardiovascular Decisions, LLC
• Inventors: Suzuki, John K., Yafuso, Masao
• Primary Examiner(s): Richman, Barry S.
• Assistant Examiner(s): Johnston, Jill
• Application Number:
  US06/917,912
• Time in Patent Office: 928 Days
• Field of Search: 422/58, 422/83, 436/133, 436/68, 436/172, 128/634, 356/39, 250/227
• US Class Current: 436/68
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: G01N 2021/6434 Optrodes
• CPC Class Codes: G01N 2021/772 Tip coated light guide
• CPC Class Codes: G01N 2021/773 Porous polymer jacket; Polymer matrix with indicator
• CPC Class Codes: G01N 21/6428 Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" in vivo A61B5/00; immunoassay G01N33/53
• CPC Class Codes: G01N 21/7703 using reagent-clad optical fibres or optical waveguides using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B
• CPC Class Codes: G01N 21/81 Indicating humidity
• CPC Class Codes: G01N 31/223 for investigating presence of specific gases or aerosols G01N31/221, G01N31/222 take precedence; actuation of fire alarm by presence of smoke or gases G08B17/10
• CPC Class Codes: Y10T 436/204998 Inorganic carbon compounds

Abstract

A gas sensor has a first aqueous phase. The aqueous phase is composed of a soluble dye in a buffer. One or more additional agent can be further added to the aqueous phase as for instance an emulisification enhancement agent. The aqueous phase is homogenized into a polymeric precursor forming a emulsion of the aqueous phase in the polymeric precursor. A catalyst and a cross-linking agent are added and the polymeric precursor material allowed to polymerize to form an emulsoid of micro-compartments of the aqueous phase in a polymeric second phase. The micro-compartments of the aqueous phase are dispersed through and permanently suspended in the polymeric second phase.

Claims

1. A gas sensing composition which comprises:

suspended dispersed microcompartments of an aqueous first phase in a cross-linked polymeric second phase wherein said aqueous first phase is present in micro-compartments smaller that 5 microns, said first phase comprising an aqueous buffer solvent and a solute, said solute including a dye soluble in said solvent, and said second cross-linked polymeric phase comprising a gas permeable, light permeable, ion impermeable and substantially aqueous impermeable polymeric material.

2. A gas sensing composition of claim 1 wherein:

said second phase comprises a carbon dioxide permeable polymeric material.

3. A gas sensing composition of claim 1 wherein:

said micro-compartments of said aqueous first phase are of a size essentially less than about 2 microns.

4. A gas sensing composition of claim 1

which is formed as a three dimensional structure having essentially orthogonal axes and wherein the outside dimension of said structure as measured along any of said axes is not greater that 125 microns.

5. A gas sensing composition of claim 1 wherein:

said solute further includes a bacteriostatic agent and an osmoregulatory agent.

6. A gas sensing composition of claim 1 wherein:

said dye is a pH sensitive dye.

7. A gas sensing composition of claim 6 wherein:

said dye is hydroxypyrene trisulfonic acid or a salt thereof.

8. A gas sensing composition of claim 1 wherein:

said aqueous buffer solvent has a pH buffer range from about 7.0 to about 8.0.

9. A gas sensing composition of claim 8 wherein:

said buffer solution is a bicarbonate ion based buffer solution.

10. A gas sensing composition of claim 1 wherein:

said material is a silicone material.

11. A gas sensing composition of claim 10 wherein:

said material is polydimethysiloxane.

12. A gas sensing composition of claim 1 wherein:

said aqueous first phase further includes a least one emulsification enhancement agent.

13. A gas sensing composition of claim 12 wherein:

said emulsification enhancement agent comprises a hydrophilic macro molecule.

14. A gas sensing composition of claim 13 wherein:

said hydrophilic macro molecule is chosen from the group consisting of water soluble dextran and polyvinyl-alcohol.

15. A gas sensing composition of claim 14 wherein:

said hydrophitic macro molecule is dextran which has a molecular weight of approximately 500,000 molecular weight units.

24. A gas sensor of claim 2 wherein:

said gas sensing composition is formed as a three dimensional structure having essentially orthogonal axes and the outside dimension of said structure as measured along any of said axes is not greater than 125 microns.

16. A carbon dioxide gas sensing composition which comprises:

a quantity of a first phase dispersed in a quantity of a second phase as a plurality of isolates smaller than 5 microns, said first phase comprising a quantity of hydroxypyrene trisulfonic acid in an aqueous buffer solution and said second phase comprises a quantity of a gas permeable, light permeable ion impermeable and substantially aqueous impermeable polymeric material.

17. The gas sensor of claim 16 wherein:

said aqueous buffer solution comprises a bicarbonate ion based buffer solution; and

said polymeric material comprises a siloxane polymer.

18. A gas sensor which comprises:

an aqueous phase having an aqueous soluble optical indicator dye dissolved therein;

a gas permeable carrier body which is essentially aqueous impermeable and ion impermeable and is capable of transmitting light at least at selected wavelengths;

a plurality of droplets of said aqueous phase dispersed in said carrier body, said droplets being supported by said carrier body;

an optical fiber having an optical face; and

said carrier body with said aqueous phase dispersed therein being located in association with said optical face of said optical fiber.

19. A gas sensor of claim 18 further including:

said carrier body with said aqueous phase dispersed therein being located directly on said optical face; and

an overcoat located on at least a portion of said carrier body which is not located directly on said optical face, said overcoat being substantially opaque to at least said selected wavelengths of light characteristic of said dye.

20. A gas sensor of claim 19 wherein:

said optical indicator is a fluoroscent dye and said selected wavelengths include the excitation and emission wavelengths of said fluoroscent dye.

21. A gas sensing composition comprising:

a gas permeable, light permeable ion impermeable and substantially aqueous impermeable matrix consisting essentially of a single polymeric material, said matrix having a plurality of micro-compartments dispersed therein; and

an aqueous phase in said micro-compartments and substantially filling said micro-compartments, said aqueous phase comprising an aqueous buffer solvent and a solute, said solute including a dye soluble in said solvent.

22. A gas sensor comprising:

a gas sensing composition which comprises suspended dispersed micro-compartments of an aqueous first phase in a cross-linked polymeric second phase wherein said aqueous first phase is present in micro-compartments smaller than 5 microns, said first phase comprising an aqueous buffer solvent and a solute, said solute including a dye soluble in said solvent, and said second cross-linked polymeric phase comprising a gas permeable, light permeable, ion impermeable and substantially aqueous impermeable polymeric material; and

optical fiber means on which said gas sensing composition is located for transmitting signals from said gas sensing composition.

23. A gas sensor of claim 22 wherein:

said micro-compartments of said aqueous first phase are of a size essentially less than about 2 microns.

25. A carbon dioxide gas sensor comprising:

a carbon dioxide gas sensing composition which comprises a quantity of a first phase dispersed in a quantity of second phase as a plurality of isolates smaller than 5 microns, said first phase comprising a quantity of hydroxypyrene trisulfonic acid in an aqueous buffer solution and said second phase comprises a quantity of gas permeable, light permeable, ion impermeable and substantially aqueous impermeable polymeric material and;

optical fiber means on which said carbon dioxide gas sensing composition is located for transmitting signals from said carbon dioxide gas sensing composition.

26. A gas sensor comprising:

a gas permeable, light permeable, substantially aqueous impermeable and ion impermeable matrix consisting essentially of a single polymeric material, said matrix having a plurality of micro-compartments dispersed therein; and

an aqueous phase in said micro-compartments and substantially filling said micro-compartments, said aqueous phase comprising an aqueous buffer solvent and a solute, said solute including a dye soluble in said solvent; and

optical fiber means on which said matrix is located for transmitting signals from said dye.