Agonists and antagonists to nicotine as smoking deterents
First Claim
1. A method of inhibiting tobacco smoking of smokers comprising administering to said smoker 3 mg to 300 mg total daily dose of a nicotine antagonist selected from the group consisting of:
- 3-Quinuclidinyl benzoate; and
3-Quinuclidinyl methylcarbamate.
1 Assignment
0 Petitions
Accused Products
Abstract
Agonists and antagonists to nicotine are used as smoking deterrents.
The nicotinic antagonists have the following structural requirements:
(1) Aromatic, cycloalkyl, and heterocyclic carbamic acid esters of di- and trialkylaminoalkyl alcohols.
(2) Aromatic, cycloalkyl, and heterocyclic thiocarbamic acid esters of di- and trialkylaminoalkyl alcohols.
(3) Aromatic, cycloalkyl, and heterocyclic carboxylic acid esters of di- and trialkylaminoalkyl alcohols.
(4) Aromatic, cycloalkyl, and heterocyclic carboxylic acid esters of heterocyclic amino alcohols.
(5) Lobelia alkaloids: lobeline, lobelanine, and lobelanidine.
The nicotinic agonists (nicotine-like) have the following structural requirements:
(1) methylcarbamic acid esters of di- and trialkylaminoalkyl alcohols.
(2) methylthiocarbamic acid esters of di- and trialkylaminoalkyl alcohols.
109 Citations
9 Claims
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1. A method of inhibiting tobacco smoking of smokers comprising administering to said smoker 3 mg to 300 mg total daily dose of a nicotine antagonist selected from the group consisting of:
- 3-Quinuclidinyl benzoate; and
3-Quinuclidinyl methylcarbamate. - View Dependent Claims (2, 3)
- 3-Quinuclidinyl benzoate; and
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4. A composition for inhibiting tobacco smoking comprising a nicotine antagonist dispersed in an inert physiologically acceptable carrier in unit dosage form containing from 1 mg to 100 mg of said nicotine antagonist per unit dose, wherein said nicotine antagonist is selected from the group consisting of 3-Quinuclidinyl benzoate;
- and 3-Quinuclidinyl methylcarbamate.
- View Dependent Claims (7, 8)
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5. A chewing gum composition for inhibiting tobacco smoking comprising a chewing gum base having a particulate nicotine antagonist distributed uniformly throughout, providing 1 mg to 100 mg of said nicotine antagonist per stick of gum, said nicotine antagonist selected from the group consisting of:
- 3-Quinuclidinyl benzoate; and
3-Quinuclidinyl methylcarbamate. - View Dependent Claims (6, 9)
- 3-Quinuclidinyl benzoate; and
Specification