Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals

  • US 4,843,086 A
  • Filed: 11/23/1987
  • Issued: 06/27/1989
  • Est. Priority Date: 12/22/1984
  • Status: Expired due to Term
First Claim
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1. A method for lowering the blood pressure of a host which comprises administering a blood pressure lowering amount of a tetrahydro-benzthiazole of the formula:

  • ##STR15## wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, an alkenyl or alkynyl group each having 3 to 6 carbon atoms, a phenyl alkyl group having 1 to 3 carbon atoms in the alkyl part, wherein the above mentioned phenyl nucleus may be substituted by 1 or 2 halogen atoms;

    R2 is a hydrogen atom or an alkyl group with 1 to 4 carbon atoms;

    R3 is a hydrogen atom, an alkyl group with 1 to 7 carbon atoms, a cycloalkyl group having 3 to 7 carbon atoms, an alkenyl or alkynyl group having 3 to 6 carbon atoms, a phenyl alkyl group having 1 to 3 carbon atoms in the alkyl part, whilst the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms; and

    ,R4 is a hydrogen atom, an alkyl group with 1 to 4 carbon atoms, an alkenyl or alkynyl group having 3 to 6 carbon atoms;

    or,R3 and R4 together with the nitrogen atom between them form a pyrrolidino, piperidino, hexamethyleneimino or morpholino group;

    or, a pharmaceutically acceptable acid addition salt thereof.

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